Cisplatin Chemotherapy: How Platinum Drugs Kill Cancer Cells & Resistance Mechanisms

these scientists in this video you'll find a well-prepared comprehensive and hopefully entertaining explanation

forces platin first we'll keep it light next we'll add some inside but for the final round you have to be an expert to

understand the profound so what is this platin so splatin is one of the chemotherapeutics that can

effectively kill cancer cells its chemical structure is simple it has a central Platinum element and it has two

chloral groups on one side and two amino groups on the other one so how can splatting kill cancer cells after being

injected into the blood this platin enters the cancer cells and damages their DNA as the damage accumulates over

time the cells will not be able to function properly and this will eventually lead to its death so the

intermingling question is why do some patients exhibit only an initial short-term response before their

tumors become resistant and continue their growth the researchers found that cancer cells

can resist the splatum by increasing the production of special enzymes that can repair the DNA and fix the damage caused

by cisplatin and for the same reason so splatin is highly effective with the testicular cancers because testicular

cancers have less repair enzymes than the rest of the body if you are entering the second phase please and take care

please press the like button and take care you will find it entertaining so what is the meaning of systems

splatances means that the two chloral groups are on the same side unlike transplantin which has two chloral

groups on opposite sides and for your knowledge transplanting is not used as a chemotherapy

due to the high concentration of chloride ions in the blood this platin is unreactive there

this is platinum manages to enter the cancer cell via transporter named ctr1 and because of the low cytoplasmic

concentration of chloride ions since Platinum becomes reactive and binds to the encountered cytosolic proteins all

the idea inside the nucleus so splata mostly targets the guanine bases and it forms one of the three following

interactions so splitting can form a monoaduct resulting from its binding with a purine base can form a cross-link

connecting two nucleotides together and this linkage can be intra in The Sims Trend or enter between two opposite

strands the previously mentioned DNA lesions can lead to double strand breaks the inhibition of RNA transcriptional

activity and the interruption of the DNA replication the cell has DNA damage recognition proteins that can lead to

either arresting the cell division or committing suicide via the induction of the apoptotic pathway

glutathione reductase is upregulated in resistant cancer cells to counter and scavenge this is splatin and protect the

cytosolic proteins from it in addition existing cancer cells can fix the single nucleotides adducts via the upper

regulation of nucleotide excision repair pathway or fixed the subsequent double strand breaks where the upregulation of

homologous recombination or non-homologous in joining pathways now let's end with the search cycle take

a deep breath and subscribe if you found what you needed this button is one of the Platinum family which is one of the

branches of the alkylating Asians 3. so splatan showed kidney damage and hearing loss especially in children accordingly

two plating compounds were used carboplatin and oxaliplatin with less reactivity but also with less side

effects cancer cells can decrease the influx or the entry of splatin by decreasing the

expression of ctr1 oc2 or increase the efflux by increasing the ATP 7A or B cancer cells can increase the DNA repair

enzymes ner HR and hej or decrease the mismatch repair pathway as the MMR system is ineffective in detecting the

platinated nucleotides and instead it removes the opposite non-platinated nucleotides

resistant cancer cells may have mutated or silenced one or multiple genes contributing to the apoptotic pathway

activation and they can over activate the arrest and repair enzymes to our date it's not known what controls p50c

to choose between apoptosis or arrest and repair congratulations you have completed the three phases and your

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