Overview of Brain Blood Supply
The brain receives its blood supply from two major arterial systems: the internal carotid arteries and the vertebral-basilar arteries. These systems divide the brain into anterior and posterior circulations, divided by an oblique line running through the temporal and occipital lobes. This division is crucial for understanding how different regions of the central nervous system are nourished, as detailed in our Comprehensive Overview of Neuroanatomy: High Yield Concepts for Exams.
Internal Carotid Artery System (Anterior Circulation)
The internal carotid artery (ICA) supplies everything above the dividing line (anterior circulation). It originates from the common carotid artery and has four parts:
- Cervical part: In the neck
- Petrous part: Through the carotid canal in the skull base
- Cavernous part: Inside the cavernous sinus (unique artery-within-a-vein anatomy)
- Cerebral part: Where major branches arise
Major Branches of the Internal Carotid
- Ophthalmic artery: Supplies the eye via the optic canal; its central artery of the retina is critical, occlusion causes blindness
- Posterior communicating artery: Connects the ICA to the posterior cerebral artery, linking anterior and posterior circulations
- Anterior cerebral artery (ACA): Runs over the corpus callosum in the longitudinal fissure; supplies the medial aspect of the cerebral hemisphere back to the parietal lobe
- Anterior communicating artery: Connects the two ACAs
- Middle cerebral artery (MCA): Runs within the lateral sulcus; supplies the lateral aspect of the cerebral hemisphere (except superior frontal/parietal and inferior temporal lobes)
Vertebral-Basilar Artery System (Posterior Circulation)
This system supplies everything below the dividing line (posterior circulation). It consists of:
- Vertebral arteries: Paired arteries arising from the subclavian artery, ascending through cervical transverse foramina and the foramen magnum
- Basilar artery: Formed by the fusion of the two vertebral arteries, running along the pons. This area is functionally linked to the Brainstem Anatomy & Functions: Vital Control Centers Explained, as the basilar artery provides its blood supply.
Branches of the Vertebral Arteries
- Posterior inferior cerebellar artery (PICA): Supplies the bottom and back of the cerebellum
- Anterior spinal artery: Runs along the front of the spinal cord
Branches of the Basilar Artery
- Anterior inferior cerebellar artery (AICA): Supplies the front and bottom of the cerebellum
- Superior cerebellar artery (SCA): Supplies the top of the cerebellum
- Clinical note: Berry aneurysms on the posterior cerebral artery or SCA can compress cranial nerve III (oculomotor), causing eye movement deficits
- Posterior cerebral artery (PCA): Terminal branch supplying the occipital lobe (primary visual cortex) and the posterior/inferior temporal lobe
The Circle of Willis
This is the brain's critical collateral circulation network, formed by the connection between the internal carotids and the basilar artery via the communicating arteries.
Structure
Formed around the optic chiasm and pituitary gland, the Circle of Willis consists of:
- Anterior communicating artery
- Anterior cerebral arteries (proximal segments)
- Internal carotid arteries
- Posterior communicating arteries
- Posterior cerebral arteries (proximal segments)
Function and Clinical Importance
- Redundancy: If a vessel within the circle is blocked (e.g., an ACA occlusion), blood can flow from the contralateral side via the anterior communicating artery, maintaining perfusion
- Beyond the circle: Terminal branches become end-arteries, so occlusions here cause ischemic stroke
- Historical note: Named after Thomas Willis (1600s), who also numbered the cranial nerves and coined "diabetes mellitus" due to the sweet smell of urine. The concept of collateral circulation is also relevant to the Introduction to Neuroanatomy: Central and Peripheral Nervous Systems Explained, which discusses how different parts of the nervous system are structurally secured.
Summary of Key Points
- Anterior circulation (ICA): Supplies most of the cerebrum, ACA (medial), MCA (lateral)
- Posterior circulation (vertebral-basilar): Supplies cerebellum, brainstem, occipital lobe, and posterior temporal lobe, PCA, SCA, AICA, PICA
- Circle of Willis: Provides collateral flow; occlusions inside the circle may be compensated, while those outside cause stroke. For a broader view of how these systems integrate with other brain structures, see our Comprehensive Overview of Brain and Spinal Cord Functions.
The ventricular system adjacent to these vascular structures is another key anatomical tier; learn more in Brain Ventricles & CSF Flow: Anatomy of the Ventricular System Explained.
okay we're going to talk about blood supply to the brain and answer the questions what parts of the brain are
supplied by the internal carotid and vertebral basal or arteries and what is the Circle of Willis hello everyone my
name is dr. Morton and I am the noted anatomist so here are the different arteries that supply the brain that
we're going to talk about and I want to just focus for a second on the internal carotid and vertebral basilar artery so
the brain is applied by two arteries internal carotid and the vertebral basilar artery so in this lateral view
we're going to pull the brain out and take a look at a line that goes that vertical a kind of obliquely through the
temporal lobe and the top of the occipital lobe like that and so that the internal carotid artery right here
supplies the anterior circulation of the brain or in other words everything above that dashed line and the vertebral
basilar artery this artery right here these two vertebral arteries ascend up and then once they hit the frame and
magnum they join to become the basilar artery and they supply the posterior circulation of the brain so it looks
something like this this is the scaffolding in which all the other arteries are going to be shelved
into to show how that we supply the brain with blood so let's start with the internal carotid artery and its branches
first okay so the internal carotid artery which is right there in that dashed line okay
and in this lateral view the common carotid artery bifurcates into an external and internal carotid artery the
internal carotid artery ascends up and then goes through the base of the skull and so there's that base of the skull
where the carotid canal is and so if we zoom in there's our internal carotid artery and the carotid canal and both on
the bottom and in the cranial base and there's the carotid canal in which the internal carotid artery traverses so we
noticed that there's a part of the internal carotid artery in the neck cervical region in the carotid canal the
petrous region in the cavernous sinus and then that's supply in the brain so there's basically these four parts of
the internal carotid artery let's do it again the cervical part of the internal
carotid artery is in the neck what's shown there that's highlighted the cervical region then there's the petrous
part which is going from the carotid canal on the base of the skulls of the crowded canal in the middle cranial
fossa between the two is the internal carotid artery the petrous part then the cavernous part is the part that's in the
cavernous sinus so there's a sphenoid bone in a coronal section in blue is the cavernous sinus one of the dural venous
sinuses flanking either side of the pituitary and there's the internal carotid artery the cavernous portion the
only Prime in anywhere in the body where you see an artery inside of a vein it's very cool so let's take a look at this
angiogram where you inject a dye into the internal carotid artery and then take an x-ray of it where if we zoom in
and take a coronal section through this lateral view of the internal carotid artery there is the internal carotid
artery in the cavernous sinus but watch it goes boom and it curves around and then if we take another cross-section
there is the cerebral part of the internal carotid artery and basically the cerebral part is that part right
there where all the other branches that we're going to talk about come off the area is the internal carotid artery the
cerebral part and one of the major one of the branches that comes off is called the ophthalmic artery and as its name
implies goes to the eye so there is a superior view of the orbit our internal carotid artery there's the ophthalmic
artery going in through the optic canal and gives rise to all these arteries that go into the orbit and clinically a
really important one is the central artery of the retina that supplies arterial supply to the retina and if
it's occluded because of diabetes or a clot then blindness or vision problems occur
another artery that comes off the internal carotid is called the posterior communicating artery that connects the
posterior cerebral artery and the internal carotid arteries it also connects our anterior and posterior
circulations on one side there's our anterior circulation of the brain and there's the posterior circulation of the
brain and the posterior communicating artery x' connect the two together it's they're paired one on either side then
there's the anterior cerebral artery right there that that supplies the front of the
cerebrum so here's the front of the cerebrum and there's our internal carotid and there is one into your
cerebral artery coursing over top of the corpus callosum within the longitudinal cerebral fissure and that's paired the
intracerebral arteries they're paired okay the distribution of the anterior cerebral artery is the medial aspect of
the cerebral Hemisphere all the way back to the parietal lobe let's see what that looks like okay I'm gonna make the
anterior cerebral artery to look yellow because that's that the picture I'm gonna show is in yellow so here's a Sam
it'd sagittal section of the brain there's our internal carotid and there's our anterior cerebral artery and there
is the anterior cerebral artery coursing over the corpus callosum and you can see its distribution okay right in the
midline of the brain and so here's a midsagittal section of the brain and everything you see in yellow is supplied
by the anterior cerebral artery the medial aspect of the cerebral Hemisphere all the way back to the parietal lobe
and even in this lateral view of the right side of the brain there you can see the anterior cerebral artery is
supplying the medial aspect of the cerebral hemispheres back to the prata lobe all right now the anterior
communicating artery is between our two anterior cerebral arteries right there our anterior communicating artery let's
do that again from this and to your view there are showing our anterior cerebral arteries and she whoops and she right
there is our anterior communicating artery connecting the two together now our middle cerebral artery is right
there in middle cerebral because it's the middle of the cerebrum so here's the brain in anterior view there's our
internal carotid artery and there is our middle cerebral artery right within that lateral sulcus and so the distribution
is through the lateral aspect of the cerebral hemispheres except for the superior portion of the frontal and
parietal lobes and for the inferior part of the temporal lobe let's see what that means okay so here's a lateral view of
the brain there's our middle cerebral artery and there's its distribution and so if we look at this picture again
there's that everything in pink is showing the distribution supplied by the middle cerebral artery all
except the superior portion of the frontal and parietal lobes and in the inferior portion of the temporal lobes
and you can see the anterior cerebral and posterior cerebral arteries supply those two areas okay so now let's focus
on there's our internal carotid artery now let's go to the vertebral basilar arteries and they're consisting of the
vertebral and the basal or arteries so now let's take a look at the vertebral arteries and its branches so the
vertebral artery is located there it's paired one on either side and it arises from the subclavian artery and ascends
up the neck through the transverse foramina of the cervical vertebra through the frame and magnum and into
the skull and so there is the vertebral artery there's the base of the skull the occipital bone there in dot-dash line
I've added the frame in Magnum and the vertebral artery comes up traverses the frame in Magnum fuses with the other
vertebral artery and then become the basilar artery a branch of the vert blar tree is the PI Co the posterior inferior
cerebellar artery which is I've just drawn on there so let's take a look at this lateral view and there is our
cerebellum and there's the posterior inferior cerebellar artery and there's the territory supplied the bottom back
of the cerebellum we also have the anterior spinal artery when we take our two vertebral arteries and we add the
anterior artery there it then courses in front of the spinal cord there's our two vertebral arteries and there's our
anterior spinal artery it supplies the front of the spinal cord now let's go to the basilar artery and its branches and
so the basilar artery is a basically taking our two vertebral arteries and they come together to make the basilar
artery so here again is our two vertebral arteries and they come together to make the basilar artery the
courses all along vertically along the pons between the ponds and the clivus of the skull branches that come off include
the anterior inferior cerebellar artery there or the I Iike and there we have the cerebellum and there's the anterior
inferior cerebellar artery the supplies the front and bottom of the cerebellum we also have the superior cerebellar
artery that's more rostral II located and there is our cerebellum and there's our superior cerebellar
artery that supplies the top of the cerebellum and there we have the superior cerebral
cerebellar arteries also shown in this view then the very end of the basilar artery is showing the posterior cerebral
artery and the posterior cerebral artery is right there and it supplies the back of the cerebrum now I just want to take
a little tangent for a second you see there's the posterior cerebral artery and there's a superior cerebellar artery
Shing cranial nerve three exits between the two of them so if there's ever a berry aneurysm on the posterior cerebral
or superior cerebellar artery you can push on that cranial nerve three and have eye deficits alright so the
posterior cerebellar arteries distribution is through the occipital lobe our primary visual cortex and to
the temporal lobe the posterior median portion and the inferior portion so here's a midsagittal section of the
brain there's our basal ER and posterior cerebral artery and there is the distribution of the posterior cerebral
artery in this picture of the mid sagittal view the posterior cerebral artery in blue supplies the occipital
lobe and then that post your medial surface of the temporal lobe and in the lateral view you can see the poster
cerebral artery in blue supplying the occipital lobe and also the bottom or inferior portion of the temporal lobe so
now we've done the basilar artery let's talk about the Circle of Willis so what's the Circle of Willis well it's
collateral circulation between our two internal carotid arteries and the vertebral basilar artery so here we have
that same picture our two internal carotid x' and the basilar arteries and then it's the collateral connection
formed between those and are communicating arteries that's the Circle of Willis and it's named after this
anatomist named Thomas Willis he's from the 1600s is he named the Circle of Willis he also was one who numbered our
cranial nerves one through 12 we still do it he actually also was the one who put the word mellitus and diabetes
mellitus because he said hey that smells like honey let's call it the diabetes a lot of urination that smells like honey
okay Circle of Willis provides redundancy it permit circulation should a part of the circle be occluded what do
we mean by that well here's that picture again you can the Circle of Willis in that dashed area
now let's say that right there is an occlusion of the anterior cerebral artery within the Circle of Willis so
blood comes up through the internal carotid artery and she blocked so blood on this side cannot get through to the
anterior cerebral artery because it's blocked but now watch that blood comes in from the contralateral internal
carotid artery and then that blood can not only go to the anterior cerebral artery on its side but also go across
the anterior communicating artery and go up to the other side of the cerebrum and so this Circle of Willis provides
redundancy within the circle now if you go outside the circle these terminal branches become and artery so if you
block them that's how you get a scheme extra' but if you block within the Circle of Willis you can get this
redundancy pretty cool right and the Circle of Willis is formed around the optic chiasm and pituitary gland so
there is a Circle of Willis in red and then in yellow is the optic chiasm which is the cross form by our two optic
nerves and there's the pituitary gland infundibular stalk as well the Circle of Willis is around them and so if we look
at this lateral view that dotted line everything above it is provided by the internal carotid artery and its branches
everything below it is supplied by the vertebral basilar artery and its branches and there are all those
branches and that my friends is the blood supply to the brain in a nutshell [Music]
[Music]
The brain receives its blood supply from two major systems: the internal carotid arteries (anterior circulation) and the vertebral-basilar arteries (posterior circulation). The internal carotid artery system supplies the anterior and middle parts of the brain, while the vertebral-basilar system supplies the posterior part, including the cerebellum and brainstem.
The ACA supplies the medial aspect of the cerebral hemisphere back to the parietal lobe. The MCA supplies the lateral aspect of the cerebral hemisphere, except the superior frontal/parietal and inferior temporal lobes. The ACA runs over the corpus callosum, while the MCA runs within the lateral sulcus.
The Circle of Willis is a collateral network of arteries at the base of the brain that connects the internal carotid and basilar systems. Its main function is to provide redundancy, allowing blood to reach brain regions via alternative routes if one artery is blocked (e.g., via the anterior/posterior communicating arteries). This can prevent stroke inside the circle, but occlusions beyond it (in terminal end-arteries) typically cause ischemic stroke.
The vertebral arteries give rise to the posterior inferior cerebellar artery (PICA) and the anterior spinal artery. The basilar artery (formed by vertebral fusion) gives off the anterior inferior cerebellar artery (AICA), superior cerebellar artery (SCA), and terminates as the posterior cerebral artery (PCA), which supplies the occipital lobe and visual cortex.
A berry aneurysm on the posterior cerebral artery or SCA can compress cranial nerve III (oculomotor nerve), leading to eye movement deficits such as ptosis, diplopia, and pupillary dilation. This is a classic neuroanatomical correlation in stroke or aneurysm cases.
The ophthalmic artery is a branch of the internal carotid artery that supplies the eye via the optic canal. Its central artery of the retina is critical for vision; occlusion of this artery causes sudden blindness in the affected eye. This highlights the importance of the ICA's role in ocular perfusion.
The brain is divided into anterior and posterior circulations by an oblique line through the temporal and occipital lobes. The internal carotid system supplies everything above this line (anterior circulation, including most of the cerebrum), while the vertebral-basilar system supplies everything below it (posterior circulation, including the brainstem, cerebellum, and occipital lobe). This division is crucial for understanding neurological deficits in vascular syndromes.
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