Understanding the Differences Between Totipotent, Pluripotent, and Multipotent Stem Cells

hello everyone welcome back to another video from shos biology in this video I'm going to clear one doubt for all of

you and the doubt is the difference between toti poent PL poent and multi poent okay in terms of potency in terms

of number and kind of cell uh stem cell can generate or uh something uh related to that stem cell can generate do they

have toy potency they have PL potency of they have multi potency what is the difference among these three terms here

here is for you do not forget this because be it cell biology molecular biology biochemistry microbiology

biotechnology background zoology background this is going to be helpful for all the different backgrounds

starting with like I'll have properties then we have the differences between all these three kinds so starting with the

very first thing even if you don't know anything else just know this that the toy potent cell can differentiate into

any kind of cell type be it uh embryonic uh tissue be it extra embrionic tissue obviously a toy potent cell can give

rise to an embryo it can give rise to a cell which is extra Outsider of the embryo that is placenta inside of

placenta the embryo lives in in case of mammals in case of humans let's say our embryo is present inside of the placenta

so extra embrionic tissue is placenta so toti poent cell can give a rise to both embrionic tissue as well as extra

embrionic tissue but Pur poent cell can produce any cell type but the extra embrionic tissue PL potential can never

produce extra embrionic tissue it can only produce any kind of cell any type of cell of embryonic tissue got it

that's the major difference between toti and plri now comes the multi poent multi poent in terms of potten is very less

where a multi poent cell can give arise to various kind of cell from a single organ system for example

digestive system there are different uh type of tissues in the digestive system different kinds of cell in that

digestive system the Goblet cell is different the epith the the the endothelial cells are different that are

present in the gastrointestinal lining the epithelial cells are different so different kinds of cells are present so

these different types of cells of all belonging to digestive tract can be produced by one lineage of the cell that

is a multi- poent kind of cell producing many kind of cells from a same tissue or organ system system that is multi potent

so you have toti poent maximum potency then PL poent little lesser than multi poent so

TPM that's how you need to remember TPM remember that okay TPM uh without that uh you cannot

remember that so remember this in your brain like this the next one is regarding the occurrence where do we

find them in toy poent like toy poent cell means we always find toy poent cells in zygote in fertilized eggs right

that is the place where the toti poten cell is always there in the zygote in the fertilized egg the very early stage

of embrionic cell development is a place in fact the earliest stage is the place where toy poent cells are found then

sooner it will become PL poent so PL poent cells are found in Inner Cell mass of the blasto Cy and there are two kinds

of cell they derived from one is the embryonic stem cells esc's are induced Pur poent stem cells

ipscs okay embrionic stem cells and induced PL poent stem cells where multipotent cells are found in various

adult tissues and organs throughout of the lifespan both toti poent and pl poent type of cells are found during the

early part of organ de organ like organism development okay development of the embryo but multi potent cells are

found throughout our lifespan examples obviously toy poent cell example zygote early embronic cells

are the toy poent cells they can give rise to embrionic tissue as well as extra embrionic tissue PL poent cells

example embrionic stem cells and induced PL poent stem cells ipsc and Es both are there multipotent cell stem cells

example hematopoetic stem cells give arise to all the type of cells of our blood and circulatory system and we know

red blood cells platlets uh lymphocytes all are produced from the same lineage of the cells like that is the

multipotent cell seatop potic hematopoetic stem cells are the examples of multi poent stem cells HSC multi

potent stem cells and you also have mezen kimal stem cells or msc's hsc's and msc's are example of this multi

potent cell type next is extra embrionic tissue can these three different kind of cells produce extra embrionic tissue the

answer is that toti potent cells can give arise to both embrionic as well as extra embrionic tissue but both PLU

poent as well as multi poent cannot produce extra embronic tissue development m al stage I told you

toy poent stem cells are found at the earliest stages of the embrionic development PL poent cells are found at

the early stage generally they are part of the Inner Cell mass of the blasto and they are found in the early emonic

development phases multi potent however found in various adult tissues and organ throughout life last things clinical

applications toy poent cells limited clinical use due to ethical concerns that is embrionic stem cells embrionic

stem cells and utilization of embrionic stem cells uh the clinical application is the limited uh use due to the ethical

concern Pur poent stem cells on the other hand can be utilized in regenerative medicines and disease

modeling particularly the induced PL poent stem cells are the ones that are utilized because when you try to work

with toti poent stem cells there are so much ethical issues is not allowed to use that so the closest to that that we

get is induced PL poent stem cells ipscs that's what we can work with for regenerative medicine as well as for the

disease modeling multipotent stem cells used for tissue repair studies regeneration and various medical

applications out there because they are basically our body tissues animal cell culture mamalian cell culture are done

with multip poent st cells so not the toti poent or FL poent so the crucial difference you already know toti poent

is the highest potential then PL poent then multi poent TPM

okay uh the easy uh way to remember that is tire pressure monitoring system nowadays this is something that is

present in cars as well as in two wheelers TPMS is known tire pressure monitoring system so the easiest way to

remember with a pneumonic is tire pressure monitoring TPM tire pressure monitoring system so toti potency PL

potency multi potency okay that's how we can easily remember that okay let me write TR

pressure monitoring to poent PL poent multi poent that's it so I believe you have a clear idea now you should never

ever confuse toti poent PL poent and multi poent now ever again in your life if you like this video please hit the

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