Optimizing Mitochondrial Health: Autophagy, Mitophagy, and Biogenesis

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Introduction to Mitochondrial Health Webinar

  • Hosted by Alma Ahmadich with presenter Jillian Crowder, a nutritional therapist and naturopath specializing in mitochondrial dysfunction.
  • Part three of a series focusing on mitochondrial support, oxidative stress reduction, and mitochondrial renewal.

Understanding Autophagy and Mitophagy

  • Autophagy is a cellular recycling process discovered about 50 years ago, crucial for maintaining energy balance during nutrient deprivation.
  • It removes damaged cell components and recycles usable parts, involving phagosomes and lysosomes.
  • Mitophagy is a selective form of autophagy targeting damaged mitochondria to maintain cellular health.
  • Proper mitophagy prevents accumulation of dysfunctional mitochondria, which is vital in cells with high mitochondrial counts like cardiac cells.

Impact of Viruses on Mitochondrial Function

  • Viruses such as SARS-CoV-2, Epstein-Barr, and cytomegalovirus disrupt mitophagy, impairing mitochondrial homeostasis and immune response.
  • This disruption facilitates viral replication and contributes to chronic conditions.
  • Bacterial infections like streptococcus also interfere with autophagic processes, linked to disorders like PANDAS and PANS.

Cautions in Stimulating Mitophagy

  • Stimulating mitophagy is not advisable if mitochondrial numbers are critically low, as it may worsen fatigue and organ function.
  • Fluoroquinolone antibiotics can impair mitochondrial DNA replication, necessitating caution.

Phytochemicals and Nutrients Supporting Mitophagy

  • Key phytochemicals include resveratrol, curcumin, berberine, quercetin, and urolithin A (from pomegranates).
  • These compounds activate multiple pathways to promote mitophagy and mitochondrial health.
  • Spermidine, found in wheat germ and sprouted buckwheat, is notable for anti-aging and mitochondrial renewal.
  • Nutraceuticals combining these agents can be tailored to patient needs, including antiviral properties.

Lifestyle Initiatives to Enhance Mitochondrial Function

Mitochondrial Biogenesis: Creating New Mitochondria

  • Regulated by PGC-1 alpha, mitochondrial biogenesis involves the growth and division of mitochondria.
  • Enzymes like parkin and PINK1 assist in quality control.
  • Nutrients such as PQQ, EGCG (green tea extract), L-carnitine, B3 vitamins (niacin, nicotinamide riboside), alpha-lipoic acid, and cyanidin-rich fruits support biogenesis. For a deeper understanding of these nutrients, refer to Optimizing Mitochondrial Function: Essential Nutrients and Health Insights.
  • Excessive mitochondrial numbers with dysfunction indicate a need for careful therapeutic approach.

Integration and Clinical Considerations

  • Mitochondria communicate with the cell nucleus and each other to regulate autophagy and biogenesis intelligently.
  • Therapeutic strategies should consider mitochondrial quantity and quality.
  • Combining phytochemicals, lifestyle changes, and cautious supplementation can optimize mitochondrial health.

Additional Resources and Q&A Highlights

  • Previous webinars and detailed articles available on the BANT website.
  • Discussion on fasting protocols tailored for women, chronic fatigue syndrome, and mitochondrial support. For insights on chronic fatigue, see Reducing Oxidative Stress in Mitochondria: Key Strategies and Insights.
  • Contact information provided for further questions and professional dialogue.

This comprehensive overview equips healthcare professionals and individuals with actionable insights to enhance mitochondrial function through targeted nutrition, lifestyle, and therapeutic interventions.

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