Introduction to Chamber Enlargement and Hypertrophy
This session covers the identification of cardiac chamber enlargement and hypertrophy through ECG analysis, focusing on right atrial abnormality, left atrial abnormality, left and right ventricular hypertrophy, and dilatation.
Key Definitions
- Enlargement: Volume overload causing eccentric hypertrophy (chamber dilatation).
- Hypertrophy: Pressure overload causing concentric hypertrophy (increased myocardial wall thickness).
Atrial Abnormalities
Right Atrial Abnormality (RAA)
- ECG Changes:
- P wave axis shifts clockwise > +75°.
- Tall P wave amplitude > 0.25 mV in lead II.
- In lead V1, tall positive deflection > 0.15 mV with unchanged duration (<0.12s).
- Morphology: Tall, peaked P waves in limb and right precordial leads.
Left Atrial Abnormality (LAA)
- ECG Changes:
- P wave axis shifts counterclockwise < +30°.
- Notched (bifid) P wave in lead II with duration > 0.12s and at least one small square between humps (P mitrale).
- In lead V1, deeper and broader negative deflection > 0.1 mV amplitude and > 0.04s duration.
- P terminal force in V1 ≥ 0.04 mV·s (Morris index).
Biatrial Enlargement
- Combination of RAA and LAA features.
- Large biphasic P wave in V1 with initial positive >1.5 mm and terminal negative >1 mm amplitude and >0.04s duration.
- Tall peaked P wave in right precordial leads and wide notched P wave in limb or left precordial leads.
Atrial Enlargement in Atrial Fibrillation
- Presence of coarse fibrillatory waves (>1 mm amplitude) suggests atrial enlargement despite absence of P waves.
Left Ventricular Hypertrophy (LVH) and Dilatation
- ECG Axis: Left axis deviation < -30° due to stronger left ventricular vector.
- Voltage Criteria: Increased QRS voltage due to thicker myocardium.
- Lead V1: Deepened S wave (small r, deep s pattern).
- Lead V6: Tall R wave.
- Additional Indicators:
- Left atrial abnormality often coexists.
- Prolonged ventricular activation time (>0.05s) measured from QRS onset to R wave peak.
- Abnormal repolarization: ST segment depression and T wave inversion in left leads.
Common LVH Diagnostic Criteria
- Sokolow-Lyon Index: R in V5 or V6 + S in V1 ≥ 35 mm.
- Cornell Voltage Criteria: R in aVL + S in V3 > 28 mm (men), > 20 mm (women).
- Cornell Product: Voltage × QRS duration ≥ 2440 mm·ms.
- Romhilt-Estes Score: Points assigned for voltage, axis deviation, ST-T changes, and activation time; ≥5 points diagnostic.
Limitations
- LVH may be present without increased voltage in obesity, lung disease, pericardial effusion.
- Increased voltage without LVH in young, thin, anemic, or post-mastectomy patients.
Right Ventricular Hypertrophy (RVH) and Dilatation
- ECG Axis: Right axis deviation ≥ +90°.
- Lead V1: Tall R wave >7 mm, RS ratio ≥1.
- Lead V6: Deeper S wave.
- **Delayed ventricular activation time in V1 >0.03s.
- Additional Signs: S1S2S3 pattern (deep S waves in leads I, II, III), right atrial abnormality, right bundle branch block.
Types of RVH
- Type A: Typical RVH with rightward QRS vector.
- Type B: RVH with incomplete right bundle branch block.
- Type C: Posterior and rightward QRS displacement, seen in chronic lung disease.
ECG in Chronic Pulmonary Disease
- Vertical heart axis with rightward and inferior shift.
- Lead I shows very small deflection (Lead I sign).
- Poor R wave progression.
Combined Ventricular Hypertrophy
- Features of both LVH and RVH.
- Tall R waves in right and left precordial leads.
- Equifacial RS complex in mid-precordial leads (Cathedral or Cat Bacheler phenomenon).
- Voltage discordance between limb and precordial leads.
Heart Failure ECG Findings
- Combination of atrial and ventricular enlargement signs.
- Arrhythmias: atrial fibrillation, premature ventricular complexes, atrial ectopics.
- Possible bundle branch blocks.
- Echocardiography recommended for confirmation.
Summary
- Right atrial enlargement: Tall P waves in lead II and V1.
- Left atrial enlargement: Notched P waves in lead II, broad negative P terminal force in V1.
- Left ventricular hypertrophy: Increased QRS voltage, left axis deviation, prolonged activation time.
- Right ventricular hypertrophy: Right axis deviation, tall R in V1, delayed activation.
- Combined hypertrophy shows mixed features.
- ECG interpretation must consider clinical context and limitations.
This comprehensive guide aids clinicians in diagnosing chamber enlargement and hypertrophy using ECG, improving early detection and management of cardiac conditions.
For further reading, check out our Comprehensive Guide to Patient Identification and Normal ECG Interpretation for foundational ECG concepts. Additionally, explore the Comprehensive Guide to ECG Lead Systems and Their Clinical Importance to understand the significance of lead placement in ECG interpretation. For a deeper dive into the analysis of heart rhythms, refer to our Comprehensive Guide to Tachyarrhythmias: ECG Analysis and Classification. Understanding the underlying mechanisms can be enhanced by reviewing the Understanding Cardiac Electrophysiology and Arrhythmias: Key ECG Insights which provides essential insights into cardiac function.
[Music] [Music] welcome all
to the session on chamber enlargement by the end of the session you will be able to identify right atal abnormality
left atrial abnormality left ventricular hypertrophy and dilatation and right ventricular hypertrophy and dilatation
in the ecg first i would like to tell you the difference between enlargement and
hypertrophy the term enlargement is used when there is volume overload of the ventricle causing eccentric hypertrophy
that is there is dilatation of the chamber of the heart the term hypertrophy is used when there is
pressure overload of the ventricle causing concentric hypertrophy that is there is increase in the thickness of
the myocardial wall so we'll be using these terms throughout the session so first we'll see about right
atrial abnormality so we all know that the impulses originate in the sa node from there the
depolarization spreads to the right atrium and to the left atrium the net vector of this is in this
direction and the normal p wave axis is between plus 30 to plus 75 degrees now let's see what happens in a right
atrial abnormality in right atrial abnormality there is a stronger right atrial vector and a normal left atrial
vector this will cause the p wave axis to shift clockwise and in right atrial
abnormality the p wave axis will be more than plus 75 degrees in left atrial abnormality there is a stronger left
atrial vector this will cause the p wave axis to shift anticlockwise and in left atrial abnormality the p wave axis is
less than plus 30 degree so that is the first difference in radiatal abnormality the p
wave axis will be shifted clockwise more than plus 75 degrees and in left atrial abnormality the p wave axis will be
shifted anti-clockwise that is less than plus 30 degrees so we'll see the morphology of p wave so if you remember
in lead 2 the p wave is having two components the right atl component and the left atrial component
the normal amplitude of p wave in lead 2 is 0.25 milli volt and the duration is less than 0.1 to second
in lead one the p wave is having a biphasic shape the positive component contributed by the right atrium and the
negative component contributed by the left atrium the amplitude of each of this complex is 0.1 millivolt and the
duration is point not for second so now let's see what happens in a right atrial abnormality so in lead to the
initial component which is contributed by the right atrium will be more will be increased in amplitude and
the latter component contributed by the left atrium will remain the same so what happens in lead to in righteous
abnormality the amplitude of the p wave increases it will be more than 0.25 millivolt whereas the duration remains
the same less than 0.12 second now let's see in v1 in v1 the right atrium the positive
component of the biphasic wave is contributed by the right atrium so that will be increased in amplitude the
negative component will remain the same so in v1 in right in rightetal abnormality you will see
a tall positive deflection and a small negative deflection the duration will remain the
same so to summarize in ritual abnormality we will see tall p wave in both limb and
right precordial leads a positive deflection of p wave is seen in lead v 1 or v 2 more than 0.15 milli
volt there is no increase in the total duration of p wave and the p wave axis in the frontal plane is more than plus
75 degrees ecg 1 we will see lead 2 and one we see p wave in lead two and v one
because p wave axis is in the direction of lead two and v one being the ripe recorded elite so here if you see the
lead two and v one what are we seeing here we have a very tall p wave of amplitude more than four millimeter
and in v1 if you see there is a biphasic p wave with the positive deflection more than 0.1 millivolt so this is an ecg
suggestive of right atrial abnormality there are many other changes in this ecg but right now we'll
concentrate on lead 2 and v1 now let's move on to left atrial abnormality left atrial abnormality unlike right atrial
abnormality it causes interatrial conduction disturbance in which the duration of the middle and the
terminal component of the p wave is prolonged oving to delayed left atrial activation
so we already discussed about the p wave axis there is an anti clockwise shift in the p wave axis and the p wave axis will
be less than plus 30 degrees let's see the morphology of p wave in left atrial abnormality so the initial
component in lead 2 which is contributed by the right atrium remains the same whereas the one contributed by the left
atrium is now prolonged so how do we how do we see it in the ecg we see a notched p wave in
lead 2 with amplitude remaining the same but the
duration more than 0.12 second and in between these two hums there should be at least one small square
in lead v1 the positive deflection contributed by the right atrium remains the same whereas the negative deflection
is now deeper and broader increases in both amplitude and duration the amplitude will be more than 0.1 milli
volt and the duration will be more than 0.04 second in left atrial abnormality so the p wave
is notched with the duration of 0.12 second or more this is called as p mitral in lead 2 and the two hums are
separated by at least one small block there is a leftward shift in the p wave axis in the frontal plane to plus 15
degrees or beyond a p terminal force in v lead v 1 equal to or more negative than 0.04 milli volt second so what is p
terminal false it is nothing but the product of the amplitude and duration of the negative component of p wave in v1
so we already told this amplitude and duration both are increased in case of left atrial abnormality so this p
terminal force will be more than point naught for millivolt second in left atrial abnormality this is called as
mores index combine the sensitivity of p terminal force in v1 more than 0.04 millivolt second and p wave duration
more than 100 millisecond is much more in diagnosing left atrial abnormality so
let's see this ecg lead 2 and v1 we can see here so what do you see here what do you see here
in lead 2 the p wave is looking bifid or notched and if you see carefully
between the two hums there is one small square one small square between two hums and in
v1 what are you seeing there is a positive component and a negative component which is
increased in duration prolonged more than 40 millisecond so if you calculate the p terminal force it will come more
than 0.04 milli volt second so satisfying the morris index so this is an ecg suggestive of left atrial
abnormality so what happens in a biatrial enlargement in case of a biatrial
enlargement both these findings both the findings of left atrial abnormality and right atrial
abnormality will be present that is there will be a large diphasic p wave in v one with an initial positive component
more than one point five millimeter and the terminal negative component more than one millimeter in amplitude and
more than 0.04 second in duration or both or if there is a tall peaked p wave in
right precordial lead and a wide notched p wave in the limb lead or left precordial lead like v5 v6 that is also
suggestive of left biatrial enlargement it is called as p tricuspidal or there will be an increase in both
amplitude and duration of p wave in limb bleeds so a combination of findings of right atrial abnormality and left atrial
abnormality are seen in ecg if there is a biatrial enlargement so let's see this ecg let's concentrate
on lead v1 so what do you see there in lead v1
there is a positive deflection which is well more than one millimeter in amplitude and a negative deflection of
duration more than 40 milliseconds so there are findings of suggestive of both right atrium and left atrial abnormality
so this ecg is suggestive of biatrial enlargement
so how will you identify atrial enlargement in presence of atrial fibrillation in atrial fibrillation you
will not see a p wave instead you will see something called as fibrillatory waves which are seen as baseline
disturbances so you will see something called as fibrillatory waves and not p waves so how will you identify a trail
enlargement so you see the fibrillatory waves if there are coarse fibrillatory waves that means the fibrillatory waves
with amplitude more than one millimeter it is suggestive of an atrial enlargement even in presence of atrial
fibrillation so to summarize in right atrial enlargement the
amplitude of the p wave is more in lead 2 and the positive deflection will be of more amplitude in v 1. in left atrial
enlargement there is a notched p wave in with increased duration in v2 and
normal positive deflection under broader and deeper negative deflection p wave in v1 a combination of these findings are
seen in biatrial enlargement so now let's move on to left ventricular hypertrophy and
dilatation so we already told the impulses originate from the cyanoatrial node they
spread to the av node and from there right ventricle is depolarized then left
ventricle is depolarized the net vector of this will be in the direction in this direction of lead 2 and the normal qrs
axis is between minus 30 degree to plus 90 degree minus 30 degree to plus 90 degree so
what happens in left ventricular enlargement in left ventricular enlargement there is a
stronger left ventricular vector which shift the p qrs axis anti-clockwise
or leftward and the left axis deviation will be there of more than minus 30 degrees in left ventricular enlargement
so the ecg the sensitivity of ecg to diagnose left ventricular hypertrophy is limited so many criteria are being
proposed to diagnose left ventricular hypertrophy in ecg most of these criteria rely on increased qrs voltage
that is because when the left ventricular is hypertrophic that means the thickness of the left ventricular
myocardium is more so the amplitude of the qrs complex will also be more so let's see in the frontal
plane i am concentrating two leads v1 and v6 v1 being the right precordial lead and
v6 being the left precordial layer so this is the normal ecg in a v1 lead v1 so here we can see a
small r wave and a deep s wave this r is contributed to the by the right ventricle and s is contributed by the
left ventricle in left ventricular hypertrophy this s will be depend the s which call which is contributed by the
left ventricle will be deepened and you get a small r d ps in v1 this if there is a small r d pass like this in v1 it
is suggestive of left ventricular hypertrophy what happens in v6 in normally v6 will have a because it is a
left precordial lead so the v6 will have a tall r wave contributed by the left ventricle and a small s wave which is
contributed by the right ventricle so in left ventricular hypertrophy there is an increase in the amplitude of this r wave
contributed by the left ventricle so there are some pointers
for left ventricular hypertrophy in the ecg one i already told you increase to qrs voltage
the second one is a left atrial abnormality during diastole when the mitral valve is open the left ventricle
and left atrium behaves like a common chamber and any pressure or volume differences in the left ventricle is
reflected to the left atrium also so the presence of an associated left atrial abnormality is a pointer for left
ventricular hypertrophy and ventricular activation time is the time taken for the impulse to travel
through the myocardium to reach the recording electrode in case of a left ventricular hypertrophy since the
thickness of the myocardium is more this ventricular activation time which is measured from the beginning of the qrs
complex to the peak of the r wave it is prolonged usually it be less than 0.05 second here it will be prolonged to more
than 0.05 second the intrinsic oil deflection is the point from which this
impulse reaches the recording electrode and so because the ventricular activation time is prolonged the
intrinsic intrinsicoid reflection is also delayed it is evidently seen in the left recording leads that is v5 and v6
if the amplitude of r and v6 is more than or equal to the r in v5 that is also suggestive of left ventricular
hypertrophy because in left ventricular hypertrophy there is some abnormality in
depolarization especially in a concentric hypertrophy it is associated with abnormalities in repolarization
abnormalities in sdt segments the two most commonly used polarization criteria for diagnosis of lvhr qrs t
angle more than 100 degree and the t wave which is upright in v2 and more negative than 0.1 milli volt in v6 so in
addition to the findings which we mentioned above if you see abnormalities in sdt segment and t wave
that is also suggestive of left ventricular hypertrophy the reciprocal changes are also present in the right
precordial needs with sd elevation and a tall tv there are a few criteria which are used commonly in clinical practice
to diagnose left ventricular hypertrophy in the ecg the most commonly used oneness zoklo leon index
so it says that the amplitude of r in v5 or v6 plus the amplitude of s in v1 if it is more than
or equal to 35 millimeter it is suggestive of left ventricular hypertrophy if the amplitude of r
wave in avl is more than 11 millimeter that is also suggestive of left ventricular hypertrophy then another
commonly used criteria is kernel voltage criteria so it says that
the sum of the amplitude of r in avl with s in v3 if it is more than 28 millimeter in men or 20 millimeter in
women it is suggestive of left ventricular hypertrophy corner product is the kernel voltage multiplied by qrs
duration in milliseconds and if it is more than or equal to 2440 milliseconds it is also suggestive of left
ventricular hypertrophy then we have rom hilt and esters criteria they assign points to certain parameters like three
points are given if there is evidence of left atrial abnormality or any increase in the voltage of qrs complex as
evidenced by an r or s in limb lead more than or equal to 20 millimeter s in v1 or v2 more than or equal to 30
millimeter rn v5 or v6 more than or equal to 30 millimeter or any stt abnormalities without digoxin
two points are given if there is a left axis deviation of more than minus 30 degrees and one point is given if
there's a slight widening of qrs complex more than 0.09 seconds and intrinsic deflection in v5 v6 more than or equal
to 0.05 second and st segment or t abnormalities with digoxin so intrinsic oil deflection i hope you
understood it is calculated from the beginning of the qrs complex to the peak of the rv the duration of that if it is
more than 0.05 second we say that there is a prolonged ventricular activation time or delay in intrinsic coil
deflection so if the total score is more than or equal to five points then it is diagnostic of lvh in the ecg a score of
four points is suggestive of probable lbh other ecg changes which are seen in lvhr are total qrs voltage that is the
sum of the amplitude of all the qrs voltage in the ecg more than 175 millimeter presence of an incomplete
left bundle branch block attenuation of a small initial q in the left oriented leads abnormal large q in the inferior
leads a small equifacing rs complex in avf or a u wave amplitude which is increased in right leads or inverted in
left leads these are also pointers to left ventricular hypertrophy so we have seen like all the criteria we have
discussed so far uses the amplitude of the qrs voltage to diagnose lvh but there are some condition in which there
will be left ventricular hypertrophy without increased voltage in the qrs complex like obesity peripheral edema
anasaka lung diseases like emphysema patients with large breast biventricular hypertrophy pericardial
effusion pleural effusion etc so in all these condition you will get a
ecg without increased voltage but the patient will be having left ventricular
hypertrophy there are some conditions in which there is increased qrs voltage not resulting from
lvh like adolescent boys patients with anemia patients who underwent left mastectomy or thin individuals so these
conditions have to be kept in mind whenever you are reading the ecg of any patient so this
is ecg number four so what are we seeing here let's concentrate on the v1 to v6 chest
leads so let's apply so closely on index here so we'll calculate the amplitude of s in v1 it is coming around 20
millimeter and we are calculating the amplitude of r in v6 it is coming 25 so the sum of these
two is more than 35 millimeter so satisfying the zokula leon index let's see the avl the
amplitude of r in avl it is more than 11 millimeter so that is also suggestive of left ventricular hypertrophy if you
apply the corneal voltage criteria we can see that r in avl plus s in v3 so r itself here is 15 s is coming around
25 15 plus 25 it is well more than 28 millimeter so according to kernel voltage criteria also this is suggestive
of left ventricular hypertrophy if you apply the rom hilt and estes criteria there is
evidence of left left ventricular hypertrophy as evidenced by increased qrs voltage
yes well beyond 30 millimeter in the leads so yes that is giving three points and there are stt abnormalities that is
also giving three points so the score is well beyond five so according to rom hilt and estes criteria also this ecg
is having left ventricular hypertrophy now let's see right ventricular hypertrophy and dilatation
so in right ventricular hypertrophy there is a stronger right ventricular vector
which shifts the net qrs axis rightward or clockwise and there's a right axis deviation of more than or
equal to 90 degree but here you have to understand that normally itself left ventricular muscle mass is much more
than the right ventricle so unless the right ventricle is severely hypertrophic this kind of axis deviation will not be
there in the ecg so in the frontal plane in right ventricular hypertrophy there will be a tall r wave and a small s wave
because i already told you the initial r is contributed by the right ventricle so in comparison i have given the left
ventricular hypertrophy ecg also so in right ventricular hypertrophy you get a tall r small s but as a left ventricular
hypertrophy you get a small r d ps in lead v1 in lead v6 in right ventricular hypertrophy are getting an r wave which
is contributed by the left ventricle and a deeper s wave which is contributed by the
right ventricle whereas in left ventricular hypertrophy you are getting a tall r wave in
v6 so the pointers for right ventricular hypertrophy in the ecg are right axis
deviation of more than or equal to 90 degree qr complex or a small q tall r in v1 or
an r wave of amplitude more than 7 millimeter in v1 or an rs ratio of more than or equal to 1 in v1 similar to left
ventricular hypertrophy in right ventricular hypertrophy also because the right ventricular muscle masses
increased there is a delayed onset of intrinsic coil deflection in v1 more than 0.03 second
we will see a small r dps complex in the left oriented leads and an equifacing rs complex in the mid
precordial leads in adults sometimes we see an s1 s2 s3 pattern that is a deep s seen in lead 1
2 3 which is also suggestive of right ventricular hypertrophy presence of right atrial abnormality or right bundle
branch block may also be seen similar to left ventricular hypertrophy we can see st segment and t wave changes
in the form of st depression and t inversion in right precordial leads like v1 and v2
three types of right ventricular hypertrophy are identified type a it is the typical rvh pattern with anterior
and rightward displacement of the main qrs vector type b is the one in which we will see
an incomplete bundle branch block and type c there is posterior and rightward
displacement of the main qrs axis it is seen predominantly in patients with chronic lung disease like emphysema in
that the lead v1 may look normal but we will see a deep s wave in the left precordial leads with right axis
deviation so i like to mention about the ecg in chronic pulmonary disease in chronic pulmonary disease like emphysema
there is over inflation of the lung which will push diaphragm downward so the heart is now aligned vertically
p qrs t wave access everything is shifted rightward and inferiorly towards lead avf since lead
1 is perpendicular to lead avf lead 1 will show very small deflection this is called as lead 1 sign in copd in
addition there will be poor r wave progression in the ecg also so this is ecg number five so what are
we seeing here so in v1 we are seeing a tall r and small s the r is definitely more than
seven millimeter in amplitude the rs ratio is definitely more than one and there are we can see the stt changes
also can you see the sdt changes in v1 v2 v3 so that is also suggestive of right
ventricular hypertrophy this looks like a type a right ventricular hypertrophy pattern
so let's see this acg in this in v1 we are seeing a q r pattern a small q tall r and there is
in v 2 and v 3 we can see a right bundle branch block pattern also so this may be type b
right ventricular hypertrophy here if you see here we have a ecg suggestion of a right atrial
abnormality also in combined ventricular hypertrophy a combination of these findings are seen combination of left
ventricular and right ventricular hypertrophy findings will be seen there is increased voltage of qrs complex
especially over the transition zones that is need v3 and v4 we will see a tall or deepest
or there will be left ventricular hypertrophy with right axis deviation or right atrial
abnormality or a left atrial enlargement with an rs ratio in v5 v6 less than or equal to 1 or s in v5 v6 more than or
equal to 7 millimeter or a right axis deviation of more than plus 90 degrees or if there is a voltage discordance
between limb and precordial leads if you see tall r in right and left precordial leads tall are in left precordial right
precordial leads and large equifacie qrs in the mid precordial leads then this is called as cat natural phenomenon that is
also suggestive of combined ventricular hypertrophy so i'll show you an ecg here we are seeing tall r in
right precordial that is p1 tall r is seen in left precordially that is v6 and in the mid precordial need we
have kind of an equifacing rs complex so this is called as cat bachelor phenomenon and this is indicative of
combined ventricular hypertrophy in heart failure you will see a combination of these findings there may
be finding suggestive of left ventricular enlargement right ventricular enlargement left atrial
abnormality right atrial abnormality any combination is possible in addition we will see arrhythmias like
atrial fibrillation premature ventricular complex atrial ectopics so those kind of arrhythmias may be
present in addition the patient may have complete left bundle branch block or right bundle branch block in the ecg
when these findings are present we suspect heart failure we have to do an echo to confirm systolic or diastolic
dysfunction of the heart these are my references thank you
Heads up!
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