Comprehensive ECG Guide to Chamber Enlargement and Hypertrophy Diagnosis

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Introduction to Chamber Enlargement and Hypertrophy

This session covers the identification of cardiac chamber enlargement and hypertrophy through ECG analysis, focusing on right atrial abnormality, left atrial abnormality, left and right ventricular hypertrophy, and dilatation.

Key Definitions

  • Enlargement: Volume overload causing eccentric hypertrophy (chamber dilatation).
  • Hypertrophy: Pressure overload causing concentric hypertrophy (increased myocardial wall thickness).

Atrial Abnormalities

Right Atrial Abnormality (RAA)

  • ECG Changes:
    • P wave axis shifts clockwise > +75°.
    • Tall P wave amplitude > 0.25 mV in lead II.
    • In lead V1, tall positive deflection > 0.15 mV with unchanged duration (<0.12s).
  • Morphology: Tall, peaked P waves in limb and right precordial leads.

Left Atrial Abnormality (LAA)

  • ECG Changes:
    • P wave axis shifts counterclockwise < +30°.
    • Notched (bifid) P wave in lead II with duration > 0.12s and at least one small square between humps (P mitrale).
    • In lead V1, deeper and broader negative deflection > 0.1 mV amplitude and > 0.04s duration.
    • P terminal force in V1 ≥ 0.04 mV·s (Morris index).

Biatrial Enlargement

  • Combination of RAA and LAA features.
  • Large biphasic P wave in V1 with initial positive >1.5 mm and terminal negative >1 mm amplitude and >0.04s duration.
  • Tall peaked P wave in right precordial leads and wide notched P wave in limb or left precordial leads.

Atrial Enlargement in Atrial Fibrillation

  • Presence of coarse fibrillatory waves (>1 mm amplitude) suggests atrial enlargement despite absence of P waves.

Left Ventricular Hypertrophy (LVH) and Dilatation

  • ECG Axis: Left axis deviation < -30° due to stronger left ventricular vector.
  • Voltage Criteria: Increased QRS voltage due to thicker myocardium.
  • Lead V1: Deepened S wave (small r, deep s pattern).
  • Lead V6: Tall R wave.
  • Additional Indicators:
    • Left atrial abnormality often coexists.
    • Prolonged ventricular activation time (>0.05s) measured from QRS onset to R wave peak.
    • Abnormal repolarization: ST segment depression and T wave inversion in left leads.

Common LVH Diagnostic Criteria

  1. Sokolow-Lyon Index: R in V5 or V6 + S in V1 ≥ 35 mm.
  2. Cornell Voltage Criteria: R in aVL + S in V3 > 28 mm (men), > 20 mm (women).
  3. Cornell Product: Voltage × QRS duration ≥ 2440 mm·ms.
  4. Romhilt-Estes Score: Points assigned for voltage, axis deviation, ST-T changes, and activation time; ≥5 points diagnostic.

Limitations

  • LVH may be present without increased voltage in obesity, lung disease, pericardial effusion.
  • Increased voltage without LVH in young, thin, anemic, or post-mastectomy patients.

Right Ventricular Hypertrophy (RVH) and Dilatation

  • ECG Axis: Right axis deviation ≥ +90°.
  • Lead V1: Tall R wave >7 mm, RS ratio ≥1.
  • Lead V6: Deeper S wave.
  • **Delayed ventricular activation time in V1 >0.03s.
  • Additional Signs: S1S2S3 pattern (deep S waves in leads I, II, III), right atrial abnormality, right bundle branch block.

Types of RVH

  • Type A: Typical RVH with rightward QRS vector.
  • Type B: RVH with incomplete right bundle branch block.
  • Type C: Posterior and rightward QRS displacement, seen in chronic lung disease.

ECG in Chronic Pulmonary Disease

  • Vertical heart axis with rightward and inferior shift.
  • Lead I shows very small deflection (Lead I sign).
  • Poor R wave progression.

Combined Ventricular Hypertrophy

  • Features of both LVH and RVH.
  • Tall R waves in right and left precordial leads.
  • Equifacial RS complex in mid-precordial leads (Cathedral or Cat Bacheler phenomenon).
  • Voltage discordance between limb and precordial leads.

Heart Failure ECG Findings

  • Combination of atrial and ventricular enlargement signs.
  • Arrhythmias: atrial fibrillation, premature ventricular complexes, atrial ectopics.
  • Possible bundle branch blocks.
  • Echocardiography recommended for confirmation.

Summary

  • Right atrial enlargement: Tall P waves in lead II and V1.
  • Left atrial enlargement: Notched P waves in lead II, broad negative P terminal force in V1.
  • Left ventricular hypertrophy: Increased QRS voltage, left axis deviation, prolonged activation time.
  • Right ventricular hypertrophy: Right axis deviation, tall R in V1, delayed activation.
  • Combined hypertrophy shows mixed features.
  • ECG interpretation must consider clinical context and limitations.

This comprehensive guide aids clinicians in diagnosing chamber enlargement and hypertrophy using ECG, improving early detection and management of cardiac conditions.

For further reading, check out our Comprehensive Guide to Patient Identification and Normal ECG Interpretation for foundational ECG concepts. Additionally, explore the Comprehensive Guide to ECG Lead Systems and Their Clinical Importance to understand the significance of lead placement in ECG interpretation. For a deeper dive into the analysis of heart rhythms, refer to our Comprehensive Guide to Tachyarrhythmias: ECG Analysis and Classification. Understanding the underlying mechanisms can be enhanced by reviewing the Understanding Cardiac Electrophysiology and Arrhythmias: Key ECG Insights which provides essential insights into cardiac function.

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