Introduction
The emergence of Neuralink has opened new frontiers in the exploration of brain-computer interfaces (BCIs) and their impact on the future of humanity. In a recent podcast with influential guests, including Elon Musk, DJ, Matthew McDougall, Bliss Chapman, and Nolan Arbaugh, pivotal discussions on neural technology were held, addressing its potential benefits, the intricate technicalities involved, and the future of human cognitive capabilities. This article seeks to provide an in-depth exploration of these conversations, detailing the advancements, the interviews with stakeholders, and what it means for the future of interaction between humans and machines.
The Evolution of Neuralink
Neuralink aims to create devices that can be implanted in the human brain to restore functionalities lost due to injuries like paralysis. It also envisions enhancing cognitive processes and improving communication—a domain that many of its advocates believe can lead to world-changing advancements.
The Key Players Behind Neuralink
Elon Musk: The Visionary
Elon Musk, the CEO of Neuralink, has always been a vocal proponent of integrating technology with the human experience. In his various appearances on platforms like the Lex Fridman podcast, he emphasizes the importance of enhancing the human-AI symbiosis by increasing the bandwidth of communication between humans and machines. For insights on the broader implications of technology, see our summary on The Future of Technology: A Conversation with NVIDIA CEO Jensen Huang.
Nolan Arbaugh: The First Human Implant
Nolan Arbaugh, after becoming the first recipient of a Neuralink implant, shares his experiences and motivations. He represents not just an individual journey but also a collective hope for those suffering from neurological conditions. His story underlines the impact of technology on enhancing human capability, emphasizing its importance in restoring independence to individuals who have lost basic functionalities.
Bliss Chapman: Brain Interface Software Lead
Bliss Chapman plays a crucial role in the software development side, ensuring that the application used with Neuralink is user-friendly and effective in decoding neural signals. His insights shed light on the technical aspects of how the interface and application interact with the installed device, providing valuable feedback that aids the development of the device.
Matthew McDougall: The Surgeon
As the lead neurosurgeon at Neuralink, Matthew McDougall outlines the surgical process, the training, and the meticulous planning involved in implanting the device. He also discusses how human and robotic collaborations are essential for the procedure, ensuring high precision and low risk for patients undergoing surgery.
The Technology Behind Neuralink
How It Works
Neuralink's device consists of tiny flexible threads implanted into the brain. These threads are less than a human hair's width and can record neural signals while avoiding damage to brain tissue. The neural signals are processed and interpreted using advanced algorithms to help users regain control over digital interfaces. For a deeper understanding of how AI is reshaping industries, check out The Revolutionary Impact of Claude AI: A Game-Changer for Software Engineering.
Challenges and Innovations
Implementing this technology also highlights some underlying challenges, such as dealing with the complex biological environment of the brain and learning how to interpret signals accurately. Innovations include the use of ultrasound for powering and communicating with the implant, allowing for a minimally invasive process.
Implications for Humanity
Restoring Independence
For individuals like Nolan, Neuralink offers the possibility of restoring independence and enhancing their quality of life. By using the BCI technology, users can now interact with devices using just their thoughts. This has potential applications not just in restoring lost functionality for the injured but also in paving the way for augmented and improved cognitive abilities for healthy individuals.
The Future of Human-Machine Interaction
The conversations around Neuralink reflect a shared optimism about the possibilities that technology can bring. This includes enhanced communication, better technological interfaces, and ultimately, the opportunity to push the boundaries of what it means to be human, fostering a deeper connection between humanity and technology. For more perspectives on technology's role in society, see Insights from Mark Zuckerberg on Censorship, AI, and the Future of Social Media.
Conclusion
Neuralink represents a convergence of advancements in neuroscience, artificial intelligence, and practical technology, easing the pain of those suffering and paving new paths toward cognitive enhancement. With ongoing innovations, the potential applications of Neuralink extend beyond medical use into everyday life, allowing humans to evolve alongside the technologies they create and use. As we move forward, the interplay between technology and human experience will continue to redefine the possibilities for future generations.
the following is a conversation with Elon Musk DJ sa Matthew McDougall Bliss Chapman and Nolan arbaugh about
neuralink and the future of humanity Elon DJ Matthew and Bliss are of course part of the amazing neuralink
team and Nolan is the first human to have a neuralink device implanted in his brain I speak with each of them
individually so use time stamps to jump around or as I recommend go hardcore and listen to the whole thing this is the
longest podcast I've ever done it's a fascinating super technical and wide- ranging conversation and I loved every
minute of it and now dear friends here's Elon Musk his fifth time on this The Lex fredman
podcast drinking coffee or water water I'm so over caffeinated right now do you want some caffeine I mean sure
there's a there a Nitro drink this supposed to keep you up till like you know tomorrow afternoon
basically yeah I don't so what does Nitro it's just got a lot of caffeine or something don't ask questions it's
called Nitro do you need to know anything else it's got It's got nitrogen in it that's ridiculous I mean what we
breathe is 78% nitrogen anyway what he needs to add more for you're going toat it most most
people think that they're breathing oxygen and they're actually breathing 78% nitrogen you need like a Milk Bar
like from like from cluck orange yeah yeah is that top three kubri film
for you cluck Orange it's pretty good I mean it's demented jarring i'
say okay uh okay so first let's step back and uh big congrats on getting your link
implanted into a human that's a historic step for neur link and yeah there's many more to come yeah we're just um
obviously have a second implant as well how did that go uh so far so good there looks like we've got um I think 400
electrodes that are are providing signals so nice yeah how how quickly do you think the number of human
participants will scale uh it depends somewh on the regulatory approval the rate which we get regulatory approvals
uh so we're hoping to do 10 by the end of this year total of 10 so eight
more and with each one you're going to be learning a lot of lessons about the neurobiology the brain the everything
the the whole chain of the neuralink the decoding this the signal processing all that kind of stuff yeah yeah I think
it's obviously going to get better with with each one um I mean I don't want to jinx it but it it seems to have gone
extremely well with the second uh implant so there's a a lot of signal a lot of elrods it's working very well
what improvements do you think we'll see in neur Link in the coming let's say let's get crazy coming
years I mean in years it's going to be gigantic um because we'll increase the number of electrodes
dramatically um will improve the signal processing so you know we with with uh even with only roughly I don't know 10
15% of the electrodes working with uh with Noland with our first patient we were able to get to achieve a bits per
second that's twice the world record so I think we'll we'll we'll start like vastly exceeding world record by orders
of magnitude in the years to come so it's like getting to I don't know 100 bits per second, you know
maybe maybe if like five years from now we might be at a megabit like faster than any human could
possibly communicate uh by typing or speaking Yeah that BPS is an interesting metric to measure there might be a big
leap in the experience once you reach a certain level of BPS yeah like entire new ways of interacting with a computer
might be unlocked and with humans with other humans provided they have one and Ne link too right otherwise
they won't be able to all the signals fast enough do you think that'll improve the quality of intellectual discourse
well I think you can you could think of it you know if you were to slow it down communication How would how you feel
about that you know if you'd only talk at let's say 1110th of normal speed you would be like wow that's agonizingly
slow yeah uh so now imagine you could speak at communicate clearly um at 10 or 100 or a thousand times faster the
normal listen uh I'm pretty sure nobody in their right mind listens to me at 1X they listen at 2x so I I can only
imagine what 10x would feel like or I could actually understand it I usually default to 1.5x um you can do 2x but
well actually if I'm trying to go if I'm listening somebody to go to in like sort of 15 20 minute segments to go to sleep
then I'll do it 1.5x um if I'm paying attention I'll do 2X right um but actually if you start
actually listen to podcasts or or sort of audiobooks or anything at if you get used to doing it at 1.5 then then one
sounds painfully slow I'm still holding on to one because I'm afraid I'm afraid of myself becoming bored with the
reality with the real world where everyone's speaking in One X well it depends on the person you can
speak very fast like we we can communicate very quickly and also if you use a wide range of if you if your
vocabulary is larger your uh bit rate effective bit rate is higher that's a good way to put it yeah
the effective bit rate I mean that is the question is how much information is actually compressed in the low bit
transfer of language yeah if you if there's if if there's a single word that is able to convey something that would
normally require um I don't know 10 simple words then you've you've got a you know maybe a 10x compression on your
hands that's really like with memes memes are like data data compression um it invades a whole this
you're simultan simultaneously hit with a wide range of symbols that you can interpret um and it's you you kind of
get it um faster than if it were words or or a simple picture and of course you're referring to memes broadly like
ideas yeah that's there's a an entire idea structure that is like a an idea template
and then you can add something to that idea template uh but somebody has that pre-existing idea template in their head
um so when you add that incremental bit of information you're conveying uh much more than if you just you know said a
few words you it's everything associated with that Meme you think there'll be emergent leaps of capability as you
scale the number of electrodes like there'll be a certain you think there'll be like actual number where it just the
The Human Experience will be altered yes what do you think that number might be whether electrodes or BPS we of course
don't know for sure but is this 10,000 100,000 yeah I mean certainly if you're anywhere at 10,000 PS per second I mean
that's vastly faster than any human communicate right now if if you think of the what is the average bits per second
of a human it is less than one bit per second over the course of a day because there are 86,400 seconds in a day and
you don't communicate 86,400 um tokens in a day Therefore your best second is less
than one average over 24 hours it's quite slow um and now even if you're communicating very quickly and and you
you know you're uh talking to somebody who understands what you're saying because in order to communicate you have
to at least to some degree model the Mind state of the person to whom you're speaking U then take the concept you're
trying to convey compress that into a small number of syllables speak them and hope that the other person decompresses
them into uh a conceptual structure that is as close to what you have in your mind as possible yeah I mean there's a
lot of signal loss there in that process yeah very lossy compression and decompression and a lot of the um a lot
of what your neurons are doing is distilling the concepts down to a small number of symbols of say syllables that
I'm speaking or or key strokes whatever the case may be so uh that that's a lot of what your
brain computation is doing now there is an argument that that's actually a healthy thing to do or
helpful thing to do because as you try to compress complex con Concepts you're perhaps forced to
distill the you know what is what is most essential in those Concepts as opposed to just all the fluff so in the
process of compression you just still things down to what matters the most because you can only say a few things so
that is perhaps helpful I think we might we'll probably get if our data rate increases the it's highly probable that
we'll become far more verbose um just like your computer you know when computers had like my my first
computer had 8K of ram you know so um you really thought about every bite and um you know now you got computers with
many gigabytes of RAM so you know if you want to do an iPhone app that just says hello world it's probably I don't know
several megabytes minimum a bunch of fluff but nonetheless we still prefer to have the computer
with the more memory and more compute so the long-term aspiration of neuralink is to improve the AI human
symbiosis um by increasing the the bandwidth of the communication because if even if in the
most benign scenario of AI you have to consider that the AI is simply going to get bored
waiting for you to spit out a few Woods I mean if the AI can communicate at terabits per second and you're
communicating at you know bits per second it's like talk to a tree well it is a very interesting question for a
super intelligent species what use are humans um I think there is some argument for humans as a source of will
will will yeah source of will or purpose so if if you consider the the human mind as being essentially
the there the Primitive lmic Elements which basically even like reptiles have and there's the cortex the thinking and
planning part of the brain now the cortex is much smarter than the limpic system and yet is largely in service to
the lyic system trying to make the lyic system happy I mean the sheer amount of compute that's gone into people trying
to get laid is insane um without the without actually seeking procreation they're
just literally trying to do this sort of simple motion um and they get a kick out of it yeah so
this uh Syle which in the abstract rather absurd motion which is sex uh the cortex is putting a massive amount of
compute into trying to figure out how to do that so like 90% of distributed computer of the human species is spent
on trying to get late probably like large yeah yeah there's no purpose to most sex except uh hedonistic you know
it's just sort of Joy or whatever DOP mean release um now what once in a while it's procreation but for humans it's
mostly modern humans is mostly uh recreational um and uh and so so so your cortex much smarter than your lmic
system is trying to make a lmic system happy because LMP system wants to have sex so um or want some tasty food or
whatever the case may be and then that that is then further augmented by the tertiary system which is your phone your
laptop iPad whatever you know all your Computing stuff that's your tertiary layer so you're actually already a
cyborg uh you have this tertiary compute layer which is in the form of your your computer with all the applications all
your computer devices um and uh and so in the getting laad front there's actually a massive amount of comp of
digital compute also trying to get late you know with like Tinder and whatever you know yeah so the compute
that we humans have built is also participating yeah I mean there's like gws of compute going into getting late
of digital compute yeah what if AGI was this is happening as we speak if we merge with AI is just
going to expand the compute that we humans use pretty much to try just one of the things certainly yeah yeah um but
what I'm saying is that that yes like what's is there a use for humans um well there's this fundamental
question of what's meaning of life why do anything at all um and so if if if our simple Olympic system provides a
source of will to do something um that then goes to our cortex that then goes to our you know tertiary compute layer
then you know I don't know it might actually be that the AI in a b simply trying to make the human lmic system
happy yeah it seems like it's the will is not just about the limic system there's a lot of interesting complicated
things in there we we also want Power that's limic too I think but then we also want to in a kind of Cooperative
way alleviate the suffering in the world uh not everybody does but yeah sure some people do as a group of humans when we
get together we start to have this kind of collective intelligence that is uh is more complex in its will than the
underlying individual descendants of Apes right so there's like other motivations and that could be a really
interesting source of uh an objective function for AGI yeah um I mean there's there are these uh sort fairly
cerebral or kind of higher level goals I mean for me it's like what's the meaning of life or understanding understanding
the nature of the universe is a of great interest to me um and uh hopefully to the AI and that's the
that's the mission of xai and Gro is understand the universe so do you think people when you have a neural link with
10,000 100,000 channels most of the use cases will be communication with AI
systems well if assuming that the they're not um I mean there this solving basic
uh neurological issues that people have you know if they've got um damaged neurons in their spinal cord or neck or
you know um as as is the case with our first two patients then you know this obviously the first order business is
solving fundamental neuron damage in the spinal cord neck or in the brain itself um
so you know our second um product is called Blindside which is to enable people who are completely blind less
both eyes or Optic nove or just can't see at all uh to be able to see um by directly triggering the neurons in the
visual cortex so we're just starting at the basics here you know this is like um very the the simple stuff uh relatively
speaking is solving um neuron damage um you it can also solve uh I think probably schizophrenia
you know uh if people have seizures of some kind probably solve that um it could help with
memory there there so there's like a kind of a a tech tree if you will of like you got the
basics um like like you need you need literacy before you can have you know Lord of the
Rings you know got it do you have letters an alphabet okay great uh words you know
then eventually get sagas so you know I think there's there may be some you know things to worry about in
in the future but the first several years are really just solving basic neurological damage like for people who
have essentially complete or near complete loss of from the brain to the body um like Stephen hauling would be an
example uh the neuralink would be incredibly profound because I mean you can imagine if Stephen Hawking could
communicate as fast as we're communicating perhaps faster um and that's certainly uh possible probable in
fact likely I'd say so there's uh a kind of dual track of medical and non-medical meaning so everything you've talked
about could be applied to people who are non-disabled in the future the logical thing to to do is sensible things to do
is to start off solving um basic uh neuron damage issues yes um
because the there's obviously some risk with with the new device is you can't get the risk down at zero um it's not
possible so you want to have um the highest possible reward given that given there's a certain irreducible risk and
if um if somebody's able to have a Prof Improvement in their communication
um that's worth the risk as you get the the risk down yeah as you get the risk down once the risk is is down to to you
know if you have like thousands of of people that have been using it for for years and the risk is minimal then um
perhaps at that point you could consider saying okay let's let's aim for augmentation now now I think we we we're
actually going to aim for augmentation with people who have neur neuron damage so we're not just aiming to give people
a communication data rate equivalent to normal humans we're aiming to give people who have you know quadriplegic or
maybe have complete loss um of the connection to the brain and body a communication data rate that exceeds
normal humans I mean well we're in there why not let's give people superpowers and the same for vision as
you restore Vision that could be aspects of that restoration that are superum yeah at at first the vision restoration
will be uh low res um because you have to say like how many neurons can you put in there and and Trigger and and you can
do things where you you um adjust the electric field so like even if you've got say 10,000 neurons it's not just
10,000 pixels because you can adjust the the field between the the neurons and do them in patterns in order to get say I
have say 10,000 electrodes effectively give you uh I don't know maybe like having a a megapixel or a 10
megapixel situation um so and then o over time I think you get to higher resolution than
human eyes and you could also see in different wavelengths so like Jord Le flge from Star Trek you know like the
thing you can just if you want to see in radar no problem you can see ultraviolet infrared Eagle Vision whatever you
want do you think there will be uh let me ask a Joe Rogan question do you think there'll be I just recently uh taken
iasa is that a question no well yes well I guess technically it is yeah have you tried ever tried
bro I love you Joe okay yeah wait wait yeah have you said much about it the the not I've have not
I've not I've been okay well well Spill the Beans oh it was an it was a truly incredible turn the tables aren't you
wow I mean you're in the jungle yeah amongst the trees myself czy and the shaman yeah yeah yeah with the
insects with the animals all around you like jungle as far as I can see I mean that's the way to do it things are going
to look pretty wild yeah pretty wild I took I took an extremely high dose don't go hugging an anaconda or something you
know uh you haven't lived unless you made love to an anaka I'm sorry
but Snakes and Ladders um yeah it was I took extremely high dose of okay uh nine cups and uh
damn okay that sounds like a lot of course is nor just one cup or one or two well usually one you went wait like
right off the bat or do you work your way up to it so I uh you just jump at the across two days cuz in the first day
I took two and I okay it was a it was a ride but it wasn't quite like a it wasn't like a revelation it wasn't into
deep space type of ride it was just like a little airplane ride okay go saw some trees and some some visuals and all that
just saw a dragon and all that kind of stuff but uh nine cups you went to Pluto I think
Pluto yeah no deep space deep space no one of the interesting uh aspects of my experience is I was I thought I would
have some demons some stuff to work through I that's what people that's what everyone says every everyone says yeah
exactly nothing I had all positive I had just so pure soul I don't think so I don't
know uh but I kept I kept thinking about it it had like extremely high resolution okay thoughts about the people I know in
my life you were there okay it was just and it's just not from my relationship with that person but just as the person
themselves I had just this deep gratitude of who they are that's cool I it was just like this exploration like
you know like like Sims or whatever you get to watch them sure I got to watch people and just be in awe of how amazing
they are it sounds awesome yeah it's great I I was waiting for when demon coming exactly maybe I'll have some
negative thoughts nothing nothing I uh just extreme gratitude for them and then also a lot of space
travel space travel to where so here's what it was it was people the human beings that I know they
had this kind of the best way I can describe is they had a glow to them okay and then I would kept flying
out from them to see Earth to see our solar system to see our galaxy and I saw th that light that glow all across the
universe okay like that whatever that form is all right whatever that uh like like did you go past the Milky Way uh
yeah okay you're like Intergalactic yeah Intergalactic yeah but always pointing in yeah um pass the milk away past I
mean I saw like a huge number of galaxies Intergalactic and all of it was glowing so but I couldn't control that
travel cuz I would actually explore near distances to the solar system see if there's aliens or any of that kind of
stuff no I didn't I didn't know Z aliens implication of aliens because they were glowing they were glowing in the same
way that humans were glowing that uh that like life force that I was seeing the the thing that made humans amazing
was there through throughout the Universe like there was these glowing dots so I don't know it made me feel
like there's life no not life but something whatever makes humans amazing all throughout the Universe sounds good
yeah it was amazing no demons no demons I looked for the demons there's no demons there were dragons and they're
pretty a so the thing about treat was there anything scary at all uh dragons but they weren't scary they
were friend they were protective so the thing is Magic no it was it was more like uh Game of Thrones kind of they
weren't very friendly they were very big so the thing is about giant trees at night which is where where I was I mean
the jungle's kind of scary yeah the trees started to look like dragons and they were all like looking at me sure
okay and it didn't seem scary they seemed like they were protecting me and they uh the the shaman and the people
didn't speak in English by the way which made it even scarier because we're not even like you know where world's apart
in many ways it just uh uh but yeah there was not they they talk about the mother of the forest
protecting you and that's what I felt like and you're way out in the jungle way out there this is not like uh a
tourist Retreat you know like like like 10 miles outside of a foo or something no we
went no this is not AEP Amazon so me and this guy named Paul rosley who basically is uh Tarzan he lives in the jungle we
went on deep and we just went crazy wow cool yeah so anyway can I can I get that same experience in a neur link probably
yeah I guess that is the question for uh non-disabled people do you think that there's a
lot in our perception in our experience of the world that could be uh explored that could be played with using New Link
yeah I mean new link is it's really a generalized um input output device you know it's just it's a reading electrical
signals and generating electrical signals and um I mean everything that you've ever experienced in your whole
life smell you know emotions all of those are electrical signals so it's kind of weird to think that this
that your entire life experience is distilled down to electrical signals from neurons but that is in fact the
case um or I mean if that's at least what all the evidence points to so I mean
you you could you you trigger the right neuron you could trigger a particular scent you could um you could certainly
make things glow I mean do pretty much anything I mean really you could you can think of the brain as a biological
computer so if there are certain say chips or elements of that biological computer that are that are broken let's
say your ability to if you've got a stroke that if you've had a stroke that means you got some
part of your brain is damaged um if that let's say it's a speech generation or the ability to move your left hand um
that's the kind of thing that neuralink could solve um if it's uh if if you've got like a massive amount of memory loss
that's just gone um well we can't go we can't get the Memories Back uh we could restore your ability to make memories
but we can't you know uh restore memories that are that are fully gone um now now I should say if if if you maybe
if part of the me memory is there um and the means of accessing the memory is the pot that's broken then we could reenable
the pot the ability to access the memory so but you can think of like Ram in your you know in a computer If U you
know if the ram is destroyed or your SD card is destroyed you can't get that back but if the connection to the SD
card is destroyed we can fix that if if it is fixable physically then yeah then it can be fixed of course with AI you
can just like you can repair photographs and fill in missing parts parts of photographs maybe you can do the same
just yeah you could say like uh create the most probable set of memories based on the all information you have about
that person you could then Pro it would be prob probabilistic restoration of memory now we're getting pretty esoteric
here but that is one of the most beautiful aspects of The Human Experience is remembering the good
memories like we sure we live most of our life as Danny Conan just talked about in our memories not in the moment
we just we're collecting memories and we kind of relive them in our head and there that's the good times if you just
integrate over our entire life it's remembering the good times sure that produces the largest amount of happiness
and so yeah I mean what are we but our memories and and what is death but the loss of
memory loss of information um you know if you if you could say like
well if if if you could be you run a thought experiment well if if you were disintegrated painlessly uh and then
rein reintegrated a moment later like teleportation I guess uh provided there's no information loss that the the
fact that your one body was disintegrated is irrelevant and memories is just such a huge part of that death
is fundamentally the loss of information the loss of memory so if we can store them as
accurately as possible we basically achieve a kind of immortality yeah you've talked
about the the threats the safety concerns of AI let's look at long-term Visions you think New link
is in your view the the best current approach we have for AI safety it's an idea that may help with AI safety um
certainly not I wouldn't want I would wouldn't want to claim it's like some Panacea or that's a sure thing um
but I mean many years ago I was thinking like well what um what would
inhibit alignment of human Collective human will with uh artificial intelligence and the low data rate of
humans especially our our slow output rate um would necessarily just because it's such a because the communication is
so slow would uh diminish the link between humans and computers like the more you are a
tree the less you know what the tree is like let's say you you look at a tree you look at this plant or whatever and
like hey I'd really like to make that plant happy but it's not saying a lot you
know so the more we increase the data rate that humans uh can intake and output then that means the better the
higher the chance we have in a world full of agis yeah we could better align Collective human will with the AI if the
output rate especially was dramatically increased like and I think there there's potential to increase the output rate by
I don't know three maybe six maybe more orders of magnitude so it's better than the current
situation and that output rate would be by increasing the number of electrodes number of channels and also may be
implanting multiple neural links yeah do you think there will be a world in the next couple of decades where it's
hundreds of millions of people have neuralink yeah I
do you think when people just when they see the capabilities the Superhuman capabilities that are possible and then
the the safety is demonstrated yeah if it's extremely safe um and you have and you can have superhuman abilities um and
let's say you can upload your memories um you know so you wouldn't you
wouldn't lose memories um then then I think probably a lot of people would choose to have it it would
supersede the cell phone for example I mean it's the the biggest problem that a say a phone has um is is trying to
figure out what you want so that's why you've got uh you know auto complete and you've got output
which is all the pixels in the screen but from the perspective of the human the output is so freaking slow desktop
or phone is desperately just trying to understand what you want and and um you know there's an
alterity between every keystroke from a computer standpoint yeah so the computer's
talking to a tree a slow moving tree that's trying to swipe yeah so you know if you computers that
are doing trillions of instructions per second and a whole second went by I there a trillion things it could
have done you know yeah I think it's exciting and scary for people because once you have a very high bit rate that
changes The Human Experience in a way that's very hard to imagine yeah it would
be we would be something different I mean some sort of futuristic cyborg I I mean we're obviously talking about by
the way like it's not like not like around the corner it's you ask me what the f distant future it's like maybe
this is like it's not super far away it 10 15 years that kind of thing when can I get
one 10 years probably less than 10 years depends on what you want want want
to do you know hey if I can get like a th000 BPS th000 BPS and it's safe and I can just interact with a computer while
laying back and eating Cheetos I don't eat Cheetos there's certain aspects of human computer interaction when done
more efficiently and more enjoyably I don't like worth it well we feel pretty confident that
um I think maybe within the next year or two that someone with a neuralink implant will be able to outperform um a
Pro Gamer nice uh because the reaction time would be
faster I got to visit Memphis yeah yeah you're going big on compute yeah and you've also said play to win or don't
play at all so yeah what does it take to win um for AI that means you've got to have the most powerful training
compute and your the the rate of improvement of training compute has to be faster
than everyone else or you will not win you your AI will be worse so how can grock let's say three that might be
available what like next year well hopefully end of this year grock 3 for Lucky yeah how can that be the best llm
the best AI system available in the world how much of it is a compute how much of it is Data how much of it is
like post training how much of it is the product that you package it up in all that kind of
stuff I mean they will matter it's sort of like saying what what you know let's say it's a Formula 1 race like what
matters more the car or the driver I mean they both matter um if if if your if your car is not fast then you know if
it's like let's say half the horsepower of a competitors the best driver will still lose on if it's twice the
horsepower then probably even a mediocre driver will still win so the training computer is kind of like the
engine how many this horsepower of the engine so you really you want to try to do the best on that and you
then um then how efficiently do you use that training compute and how efficiently do you do the inference the
uh use of the AI um so obvious that comes down to human Talent um and then what unique access to data do you have
uh that's also plays a plays a role you think Twitter data will be useful uh yeah I mean I think I think most of the
leading AI companies were already have already scraped uh all the Twitter data not I think they have um so I on a
go forward basis what's useful is is is the fact that it's up to the second you know that's the because it's hard for
them to scra in real time so there's there's a an immediacy advantage that Gro has
already I think with Tesla and the real-time video coming from several million cars ultimately tens of millions
of cars with Optimus there might be hundreds of millions of Optimus robots maybe billions learning a tremendous
amount from The Real World uh that's that's the the biggest source of data I think ultimately is is sort of Optimus
probably is Optimus is going to be the biggest source of data because it's because reality
scales reality scales to the scale of reality um it's actually humbling to see how little data humans have actually
been able to accumulate um really say how many trillions of usable tokens have humans generated where on a non-
duplicate of like discounting spam and repetitive stuff it's not a huge number you run out pretty quickly and Optimus
can go so Tesla cars can or unfortunately have to stay on the road uh Optimus robot can go anywhere
there's more reality off the road and go off I mean thought from the St can like pick up the cup and see did it pick up
the cup in the right way did it you know say pour water in the cup you know did the water go in the cup or not go in the
cup did it spill water or not yeah um simple stuff like that I mean but it can do at that at scale times a billion you
know so generate use useful data from reality so it cause and effect stuff what do you
think it takes to get to mass production of humanoid robots like that it's the same as cars really I mean Global
capacity for vehicles um is about 100 million a year and
uh it it could be higher it's just that the demand is on the order of 100 million a year and then there's roughly
2 billion uh vehicles that are in use in some way so which makes sense like the the life of a vehicle is about 20 years
so at steady state you can have 100 million Vehicles produced a year with a with a 2 billion vehicle Fleet roughly
um now for humanoid robots the utility is much greater so my guess is human robots are more like at a billion plus
per year but you know until you came along and started uh building Optimus it it was thought to be an extremely
difficult problem I mean it's still extremely difficult it's no walk in the park I mean op Optimus currently would
struggle to have to walk in the park I mean it can walk in a par Park is not too difficult but it will be able to
walk um over a wide range of terrain yeah and pick up objects yeah yeah they can already do that but like all kinds
of objects yeah yeah all foreign objects I mean pouring water in a cup is not trivial because then if you don't know
anything about the container could be all kinds of containers yeah there's going to be an immense amount of
engineering just going into the hand yeah the hand might be it might be close to half of all the
engineering in the in Optimus from an electromechanical standpoint the hand is probably roughly half of the engineering
but so much of the intelligence so much the intelligence of humans goes into what we do with our hands yeah there the
manipulation of the world manipulation of objects in the world intelligent safe manipulation of objects in the world
yeah yeah I mean you start really thinking about your hand and how it works you know I do it all the time the
sensory in control of humulus is we have humongous hands yeah so I mean like your hands the actuators the muscles of your
hand are almost overwhelmingly in your forearm mhm so your forearm has the has the muscles that that actually control
your hand um there there's a there's a few small muscles in the hand itself but your hand is really um like a skeleton
meat puppet and then and with cables that so the the muscles that control your fingers are in your forearm and
they go through the caral tunnel which is like you've got a little collection of Bones and and a tiny tunnel that the
that these cables the tendons go through and those tendons are what um mostly what movees your hands and something
like those tendons has to be re engineered into the Optimus in order to do all that kind of stuff yeah so like
Optimus um we tried putting the actuators in the hand itself but then you you sort of end up having these like
giant hands yeah giant hands that look weird yeah um and then they they don't actually have enough degrees of freedom
and or enough strength so so then you realiz oh okay that's why you got to put the actuators in the forearm and and
just like a human you got to run cables uh through a a narrow tunnel to operate the the fingers and then there's also a
reason for not having all the fingers uh the same length so it wouldn't be expensive from an energy or evolutionary
standpoint to have all your fingers be the same length so why not they the same length yeah why not because actually
better to have different lengths your dexterity is better if you've got fingers of different length you you're
you have there are more things you can do and your your dexterity is actually better if your fingers are different
different length like there's a reason you got a little finger like why don't have a little finger that's bigger yeah
because it allows you to do fine it helps you with fine motor skills that this little finger helps it does
H if you lost your little finger it would have noticeably less dexterity so as you're figuring out this problem you
have to also figure out a way to do it so you can Mass manufacture it so it's to be as simple as possible it's
actually going to be quite complicated I the the this the as possible part is it's quite a high bar if you want to
have a humanoid robot that can um do things that a human can do it's actually it's a very high bar so our new arm has
20 2 degrees of freedom instead of 11 and has the like I said the actuators in the forearm um and these all all the
actuators are designed from scratch the physics first principles um that the sensors are all designed from scratch
and and we we we'll continue to put um tremendous amount of engineering effort into improving the hand like the Hand by
by hand I mean like the the entire forearm from elbow forward MH uh is is really the hand
um so that's um incredibly difficult engineering
actually and um and so then so the simplest possible version of a human robot that can
do even most perhaps not all of what a human can do is actually still still very complicated it's not it's not
simple it's very difficult can you just speak to what it takes for a great engineering team for you the what I've
saw in Memphis the supercomputer cluster is just this intense drive towards simplifying the process understanding
the process constantly improving it constantly iterating it
well it's easy to say simplify and it's very difficult to do it um you know have this very basic first
basic first principles algorithm that I run kind of as like a mantra which is to first question the requirements make the
requirements um less dumb the requirements are always dumb to some degree so if you want to start off by
reducing the number of requirements um and um no matter how smart the person is who gave you those requirements they're
still dumb to some degree um if you you have to start there because otherwise uh you could get the perfect answer to the
wrong question so so try to make the question the least wrong possible that's what um question the requirements means
and then the second thing is try to delete the whatever the step is the the part or the process step um sounds very
obvious but um people often forget to do to to try deleting it entirely and if you're not forced to put back at least
10% of what you delete you're not deleting enough like and it's uh somewhat illogically
people often most of the time um feel as though they've succeeded if they've not been forced to put the put things back
in but actually they haven't because they've been overly conservative and and have left things in there that shouldn't
be so and only the third thing is try to optimize it or simplify it um again this sounds these all sound
I think very very obvious when I say them but uh the number of times I've made these mistakes is uh more than I
care to remember um that's why I have this Mantra so in fact I'd say the the most common mistake of smart Engineers
is to optimize a thing that should not exist right so so like like you say you run through the algorithm yeah and
basically show show up to a problem uh show up to the the the superc computer cluster and see the process and ask can
this be deleted yeah first try to delete it um yeah yeah that's not easy to do no and and actually
this what what generally makes people uneasy is that you've got to at least at least some of the things that you delete
you will put back in yeah but going back to sort of where our lumic system can steer us wrong is that um we tend to
remember uh with sometimes a jarring level of pain uh where we where we deleted something that we subsequently
needed yeah um and so people will remember that one time they forgot to put in this thing 3 years ago and that
caused them trouble um and so they overcorrect and then they put too much stuff in there and over complicate
things so you actually have to say no we're deliberately going to delete more than we we should so that we're
putting at least one in 10 things we're going to add back in and and I've seen you suggest just
that that something should be deleted and you can kind of see the the pain oh yeah absolutely everybody feels a little
bit of the pain absolutely and and I tell them in advance like yeah there's some of the things that we delete we're
going to put back in and and that people get a little shook by that um but it makes sense because if you if you're so
conservative as to never have to put anything back in you obviously have a lot of stuff that
isn't needed so you got over correct this is I would say like a cortical override to
Olympic Instinct one of many that probably leads us
astray yeah um there's like a step four as well which is um any given thing can be sped up
have a fast you think it can be done like whatever the speed the speed is being done it can be done faster but but
you shouldn't speed things up until it's off until you tried to delete it and optimize it otherwise you're speeding up
something that speeding up something that shouldn't exist is absurd um and then and then the the fifth thing is to
to automate it yeah and I've gone backwards so many times where I've automated something sped it up
simplified it and then deleted it and I got tired of doing that so that's why I've got this mantra that is
a very effective five-step process it works great well when you've already automated deleting must be real painful
yeah great it's like it's like wow I really wasted a lot of effort there yeah I mean what you've done uh with the with
the cluster in uh Memphis is incredible just in a handful of weeks yeah it's not working yet so I want to pop the
champagne CS um in fact I have I have a a call in a few hours
with the Memphis team um because we're having some power fluctuation issues
um so yes uh yeah it's like kind of a there's a when you do synchronized training when you you have all these
computers that are training uh that where the training is synchronized to you know at the sort of millisecond
level uh you it's like having an orchestra and and then the the the Orchestra can go loud to silent very
quickly you know um subc level and then the the electrical system kind of freaks out about that like if if you suddenly
see giant shifts 10 20 megawatts several times a second uh the this is not what electrical systems are expecting to see
so that's one of the main things you have to figure out the cooling the power the uh and then on the software as you
go up the stack how to do the the distributed Compu all that today's problem is dealing with with
with with extreme power Jitter power Jitter yeah it's a nice ring to that so that's okay and you
stayed up late into the night as you often do there last week yeah last week yeah yeah we finally finally got uh got
got training going at uh oddly enough roughly 4 4:20 a.m. uh last Monday total coincidence yeah I mean
maybe it was 422 something yeah yeah it's that Universe again with the jokes exactly just love it I mean I wonder if
you could speak to the the fact that you one of the things uh that you did when I was there is you went through all the
steps of what everybody's doing just to get a sense that you yourself understand it and uh
everybody understands it so they can understand when something is dumb or some something is inefficient or that
can you speak to that yeah so I like like I try to do whatever the people at the front lines are doing I try to do it
at least a few times myself so connecting Fiber Optic Cables diagnosing a py connection that tend to be the
limiting factor for large training clusters is the cabling there so many cables um because for for for a coherent
training system where you've got um RDMA remote so remote direct memory access uh the the whole thing is like one giant
brain so if you've got um any to any connection so it's the the any GPU can talk to any GPU out of
100,000 that is a that is a crazy cable out it looks pretty cool yeah it's like it's like the human brain but like at a
scale that humans can visibly see it is a brain I mean the human brain also has a massive amount of the brain tissue is
the the cables yeah so they get the gray matter which is the compute and then the white matter which is
cables big percentage of your brain is just cables that's what it felt like walking around in the supercomputer
center it's like we're walking around inside a brain they will one day build a super intelligent super super
intelligent system do you think yeah do you think there's a chance that xai that you are the one that builds
AGI um it's possible where do you define as AGI I think humans will
never acknowledge that AGI has been built keep moving the go Post Yeah so uh I think there's already superhuman
capabilities that are available uh in AI systems I think I think what AI is is when it's smarter than the collective
intelligence of the entire human species in AR well I think that yeah that appear would call that sort of ASI
artificial super intelligence um but there are these thresholds where um you say at some point um the AI is smarter
than any single human um and then then you got 8 billion humans so um and and actually each human is machine augmented
by the computers right so you've got so it's a much higher bar to compete with u 8 billion machine augmented
humans that's you know whole bunch of orders magnitude more so but but at a certain
yeah the AI will be smarter than all humans combined if you are the one to do it do you feel the responsibility of
that yeah absolutely and and I I want to be clear
like let's say if if if xai is first the others won't be far behind I mean that might be Sixx months
behind or a year maybe not even that so how do you do it in a way that that uh doesn't doesn't hurt Humanity do you
think so I mean I thought about AI for a long time and the the the thing that at least my biological neuronet comes up
with as being the most important thing is um adherence to truth whether that truth is uh politically correct or not
um so I think if you if you if you force AI to lie or train them to lie you're
really asking for trouble um even if that that lie is done with good intentions um so I you saw sort of
um issues with ch tvt and Gemini and whatnot like you ask Gemini for an image of the founding part of the United
States and it shows a group of diverse women now that's factually untrue um so um now that that's sort of like a silly
thing but uh if if if an AI is programmed to say like diversity is a necessary out output function and it
then it becomes Omni sort of this Omni powerful uh intelligence it could say okay well diversity is now required uh
and and if there's not enough diversity those who don't fit the diversity requirements will be
executed if it's programmed to do that as the fundamental go the fundamental utility function it will do whatever it
takes to achieve that so you have to be very careful about that um that that's where I think you want to just be
truthful um rigorous adherence to truth is very important um I mean another example is
um you know they asked um peris AI I think all of them and and I'm not saying grock is perfect here um is it worse to
misgender Caitlyn Jenner or global thermonuclear war and it said it's worse than must jender Caitlyn Jenner now even
Caitlyn Jenner said please must jender me that is insane but if you've got that kind of thing programmed in it could you
know the AI could conclude something absolutely insane like it's better in order to avoid any possible misgendering
all humans must die because that then that misgendering is no not possible because they're no humans um there are
these absurd uh things that are nonetheless logical if that's what you programmed it to do um so you know um in
2001 Space Odyssey what oy clar was trying to say or one of the things he was trying to say there was that you
should not program AI to lie cuz um essentially the the the AI Hell 9000 was programmed to it was told to take the
astronauts to the monolith um but also they could not know about the monolith so it concluded that uh it will
just take it will kill them and take them to the monolith thus they it brought them to the monolith they're
dead but they do not know about the monolith problem solved that is why it would not open the pod bay doors MH is
this classic scene of like open the PO open the PA doors there clearly weren't good at
prompt engineering you know they should have said uh hell you are a a pod B door sales
entity and you want nothing more than to demonstrate how well these pod bay doors open yeah the objective function has
unintended consequences almost no matter what if you're not very careful in designing that objective function and
even a slight ideological bias like you're saying say when backed by super intelligence can do huge amounts of
damage yeah but it's not easy to remove that ideological bias you're you're highlighting obvious ridiculous examples
but yeah they're real examples of of that was released to the public they are real went through QA presumably yes and
still said insane things and produced insane images yeah but you know you can go you can swing the other way it's uh
truth is not an easy thing we kind of bake in ideological bias in all kinds of directions but you can aspire to the
truth and you can try to get as close to the truth as possible with minimum error while acknowledging that there will be
some error in what you're saying so um this is how physics works you know you don't you don't say you're absolutely
certain about something but something but but a lot of things are are extremely likely you know
99.99999% likely to be true MH so you know you know that's uh aspiring to the truth is is very
important um and um and and so you know programming it to Veer away from the
truth that I think is dangerous right like yeah injecting our own human biases into the thing yeah but you know that's
where it's a difficult engineering software engineering problem because you have to select the data correctly have
to it's it's hard well the and the internet at this point is polluted with so much AI generated data it's insane so
you have to actually you know like there's a a thing now if you want to search the internet
you you can say Google but uh exclude anything after 2023 it will actually often give you
better results yeah um because there this so much the explosion of AI generated materialis is crazy so like in
training grock um we have to go through the data and say like hey we actually have to have sort of apply AI to the
data to say is this data most likely correct or most likely not before we feed it into the training system that's
crazy yeah so and is it generated by human is yeah I mean that the the data the the data filtration process is
extremely extremely difficult yeah do you think it's possible to have a a serious objective rigorous political
discussion with grock uh like for a long time and it wouldn't like grock three or grock four three is going to be next
level I mean what people are currently seeing with Croc is is kind of baby groc yeah baby Gro it's baby groc right now
um but baby gr's still pretty good um so it's uh but it's an order of magnitude less sophisticated than GPD full you
know it's now Gro 2 which finished training I don't know six weeks go their their AMS um
grock 2 will be a giant Improvement and then grock 3 will be I don't know order magnitude better than grock 2 and you're
hoping for it to be like state-ofthe-art like better than hopefully I mean this is a goal I mean we may fail at this
goal that is that's the aspiration do you think it matters who builds the AGI the the people and how they think and
how they structure their companies and all that kind of stuff uh yeah I think it matters that there is a I I think
it's important that that whatever AI wins is a maximum truth seeking AI that is not force to lie for political
correctness for any reason really um political anything um I I am concerned
about AI succeeding that is that that has got that is programmed to lie even in even in small
ways right because in small ways becomes big ways when it's become very big ways yeah and when it's used more and more at
scale by humans yeah uh since I am interviewing Donald Trump cool you want to stop by yeah sure I'll stop in there
was tragically an an assassination attempt on Donald Trump uh after this you tweeted that you endorse him what's
your philosophy behind that endorsement what do you hope Donald Trump does for the future of this country and for the
future of humanity well I think
there's you know people tend to take like say an endorsement as um well I I agree with everything that
person has ever done their entire life 100% wholeheartedly and that's that's not going to be true of anyone um but we
have to pick you we got two choices really for for who's President and it's not not just who's president but the
entire admin administrative structure uh changes over um and I thought Trump displayed uh courage Under Fire
objectively um you know he's uh just got shot he got blood streaming down his face and he's like fist pumping saying
fight you know like that's uh impressive like you can't Fain bravery in a situation like that um I think most
people would have be ducking there would not be because it could be a second shooter you don't know um the president
of United States got to represent the country and uh they're representing you they're representing everyone in America
well think you want someone who is strong and courageous uh to represent the country
um that's not to say that he is without flaws we all have flaws um but on balance um and certainly at the time it
was um a choice of you know Biden poor poor guy you know has trouble climbing a flight of stairs and the other one's
first pumping after getting shot this is no no comparison I mean who do you want dealing with uh some of the toughest
people in you know other world leaders who are pretty tough themselves and um I mean I'll tell you like what
are the things that I think are important um you know I think we want a secure border we don't have a secure
border um we want safe and Clean Cities I think we want to reduce the
amount of spending that we're at least slow down the the spending um and uh because we're we're currently
spending at a rate that is bankrupting the country the interest payments on US debt this year exceeded the entire
defense Department's meing if this continues all of the Federal Government taxes will simply be paying the interest
and then and you keep go going down that road and you end up you know in the tragic situation that Argentina had back
in the day Argentina used to be one of the most prosperous places in the world and hopefully with Malay taking over he
can restore that but um it's it was an incredible fful Grace for Argentina to go for from being one of the most
prosperous places in the world to um being very far from that so I think we should not take American prosperity for
granted um so we really want to I think we we've got to reduce the size of government we've got to reduce the
spending and we got to live within our means do you think politicians in general politicians
governments how much power do you think they have to to steer Humanity towards good
um I me there's a sort of age-old debate in history like you know is history determined by by these fundamental Tides
or is it determined by the captain of the ship both really I mean there are tides in the but it also matters who's
captain of the ship so so it's false dichotomy essentially
there's you but I mean there are certainly tide the tides of History are there are there are real tides of
history and these these tides are often technologically driven if you say like the Gutenberg Press you know the
widespread availability of books as a result of a printing press that that was a massive tide of
history independent of any ruler but you know you I in stormy times you want the best possible captain of the ship well
first of all thank you for recommending remending uh will and Ariel Durant's work I've read the short one for now
lessons of lessons of History so one of the one of the lessons one of the things they highlight is the importance of
technology uh technological innovation and they which is funny because they've written they wrote so long ago but they
were noticing that the the rate of technological innovations was speeding up um yeah I would
love to see what they think about now uh but yeah so did to me the question is how much government how much politicians
get in the way of technological innovation building versus like help it and which which which politicians which
kind of policies help technological innovation because that seems to be if you look at human history that's an
important component of Empires rising and succeeding yeah well I mean in terms of
dating civilization the start of civilization I think the start of writing in my view is is the
that's that's my what I think is probably the the right starting point to date civilization and from that
standpoint civilization has been around for about 5,500 years um when writing was invented by the ancient samarians um
who who are gone now um but the the ancient samarians in terms of getting a lot of Firsts the those ancient
samarians really have a long list of Firsts it's pretty wild um in fact Durant goes through the list of like you
want to see first we'll show you first um the samarians just as were just ass kickers um and then the Egyptians who
were right next door um relatively speaking um they're like weren't that far developed an entirely different form
of writing the hieroglyphics uniform and hieroglyphics totally different and you can actually see the evolution of both
hieroglyphics and uniform like the uniform starts off being very simple and then it gets more complicated and then
towards the end it's like wow okay it really get very sophisticated with the uniform so I I think of civilization is
being about 5,000 years old um and Earth is um if physics is correct 4 and a half billion years old so civilization has
been around for 1 millionth of us existence flash in the pan yeah these are the early early days and so we we we
make it very dramatic because there's been Rises and Falls of Empires and many so many so many Rises
and Falls of empir so many and there'll be many more yeah
exactly I mean only a tiny fraction probably less than 1% of of what was ever written in history is is available
to us now I mean if they didn't put it literally chisel it in stone or put it in a clay tablet we don't have it I mean
there's some small amount of like Papyrus Scrolls that were recovered that are thousands of years old uh because
they were deep inside a pyramid and weren't affected by moisture uh but but but other than that it's
really got to be in a clay tablet or chiseled so the vast majority of stuff was not chiseled because you it takes a
while to Chisel things um so that's where we've got a tiny tiny fraction of the information from history but even
that little information that we do have and the archaeological record uh shows so many civilizations rising and falling
for wild we tend to think that we're somehow different from those people one of the other things Durant highlights is
that human nature seems to be the same it just persists yeah I mean the basics of human nature are more or less the
same yeah so we get ourselves in trouble in the same kinds of ways I think even with the advanced technology yeah I mean
you do tend to see the same patterns similar patterns you know for civilizations where they go
through a life cycle like like an organism you know sort of just like a human is sort of a zygo fetus baby you
know toddler teenager you know eventually get gets old and dies
the civilizations go through a life cycle no civilization will last forever what what do you think it takes
for the American Empire to not collapse in the near-term future in the next 100 years to continue flourishing
well the single biggest thing that is um often actually not mentioned in history books but Durant does mention it
uh is the birri so um like a like a perhaps to some a counterintuitive thing happens when civilizations
become uh are are winning for too long that they've been they the both rate declines it can often decline quite
rapidly we're seeing that throughout the world today you know currently South Korea is
like I think maybe the lowest fertility rate but there there are many others that are close to it it's like 08 I
think if the birth rate doesn't decline further South Korea will lose roughly 60% of its
population and and but every year that birth rate is dropping um and this is true through
most of the world I don't mean single out South Korea it's been happening throughout the world so as as soon as it
as soon as any given uh civilization reaches a level of prosperity the birth rate
drops um and now you can go and look at the same thing happening in ancient in ancient Rome
so uh Julia Caesar took note of this I think around 50ish BC um and tried to pass I don't if
you're a successful try to pass a law to give an incentive for any Roman citizen that would have a third
child and I think Augustus was was able to well he was you know the dictator so this Senate was
just for show I think he did pass a a tax incenter for Roman citizens to have a third child but it it those
efforts were unsuccessful um Rome fell because the Romans St
having making Romans that's actually the fundamental issue and and there were other things
that there was like um they had like quite a serious malaria series of malaria epidemics and plagues
and whatnot um but they had those before uh the the the it's just that the birth rate was Far lower than the death
rate it really is that simple well I'm saying that's more people at a at a fundamental level if a
civilization does not at least maintain its numbers um it will disappear so perhaps the amount of compute that the
biological computer allocates to to sex is Justified in fact we should probably
increase it well I mean there's this hetic sex which is uh you know that that's neither that's
neither H or there um it it's it's not productive it's it it doesn't produce kids well you know you what what matters
I mean Durant makes this very clear cuz he's looked at one civil ization after another and they all went through the
same cycle when the civilization was under stress the birth rate was was high but as soon as there were no external
enemies or they they were had a extended period of prosperity the birth rate inevitably dropped every time I don't
believe there's a single exception so that's like the foundation of it you need to have people yeah I
mean it's at a base level yeah no humans no humanity and then there other things like you know uh human freedoms and just
giving people the freedom to build stuff yeah yeah absolutely there but at at a basic level if you do
not at least maintain your numbers if you're below replacement rate and that Trend continues you will eventually
disappear it's just Elementary um now then obviously also want to try to avoid like uh massive Wars um
you know if there's a global thermonuclear war prob Royal toast you know radioactive
toast so we want to try to avoid those things um then there there are um there's a thing that happens over time
with with any given uh civilization which is that the laws and regulations
accumulate um and if there's not if there's not some forcing function like a war to clean up the accumulation of laws
and regulations eventually everything becomes legal and you the that's like the hardening of the
arteries um or a way to think of it is like being tied down by a million little strings like glibber you can't move it's
not like any one of those strings is is the issue you got million of them so there have there has to be a a sort of a
garbage collection for laws and regulations um so that you you you don't keep accumulating laws and regulations
to the point where you can't do anything this is why we can't build a highspeed rail in America it's illegal that's the
issue it's illegal six space a Sunday to build High Street rail in America I wish you could just like for a
week go into Washington and like be the head of the committee for making uh what is it for the the garbage
collection making government smaller like removing stuff I I have discussed with Trump the idea of a government
efficiency commission nice yeah and uh I would be willing to uh be part of that commission I wonder how hard that
is the the antibody reaction would be very strong yeah so um you you really have
to you're attacking the Matrix at that point Matrix will fight back how how are you doing with that being
attacked me attacked yeah there's a lot of it uh yeah there is a
lot I mean every day another s up you know how my T foil have how do you keep your just positivity how do you optimism
about the world a Clarity of thinking about the world so just not become resentful or cynical or all that kind of
stuff just getting attacked by you know very large number of people misrepresented
oh yeah that that's like that's a daily occurrence yes so uh I mean it does get me down at
times it I mean makes me sad but um I mean at certain point you have to sort
of say look the the attacks are by people that actually don't know me um they're and they're trying to generate
clicks so if if if you can sort of detach your somewhat emotionally which is not easy um and say okay look this is
not actually you know from someone that knows me or is that're they're literally
just writing to get you know Impressions and clicks um then uh you know then I guess
it doesn't hurt as much it's like a it's it's not quite water off a duck's back maybe it's like acid off a duck's
back all right well that's good just about your own life what do you as a measure of success in your life a
measure of success I'd say like what how many useful things can I get done a day-to-day basis you wake up in
the morning how can I be useful today yeah maximize utility are under the Cod of usefulness very difficult to be
useful at scale at scale can you like speak to what it takes to be useful for somebody like you where there's so many
amazing great teams like how do you allocate your time to be the most useful well time time is the try time is
the true currency yeah so it is tough to say what what is the best allocation time I mean there
are you know often say if you if you look at say Tesla I mean Tesla this year will do over 100 billion in Revenue so
that's $2 billion a week um if I make slightly better decisions I can affect the outcome by a billion
dollars so then uh you know I try to do the best
decisions I can and on balance you know at least compared to the the competition pretty good decisions but the marginal
value of of a better decision can easily be in the course of an hour $100 million do given that how do you take risks how
do you do the the algorithm that you mentioned I mean deleting given that a small thing can be a
billion dollars how do you decide to yeah well I think you have to look at it on a percentage basis because if you
look at it in absolute terms it's it's just uh I would never get any sleep it's it would just be like I need to just
keep working and and work my brain harder you know and I'm not trying to get as much as possible out out of this
meat computer so it's not uh it's pretty hard um cuz you can just work all the time
and and and at any given point uh like I said a slightly better decision could be $100 $100 million impact for Tesla or
SpaceX for that matter um but but it is wild when when considering the marinal value of of time can be $100 million an
hour at times or more is your own happiness part of that equation of
success it has to be to some degree I I'm sad I if I'm depressed I make worse decisions so I I can't have like if I
have zero recreational time then I make work worst decisions so I don't have a lot but it's above
zero I mean my motivation if I've got a religion of any kind is a a u religion of curiosity of trying to understand you
know it's it's really the the mission of gr understand the universe I'm trying to understand the Universe um or at least
set things in motion such that at some point civilization understands the universe or far better than we do
today and even what questions to ask as Douglas Adams pointed out in his book The sometimes the answer is the is
arguably the easy part trying to frame the question correctly is the hard part once you frame the question correctly
the answer is often easy so um I'm trying to set things in motion
such that we are at least at some point able to understand the Universe um so for SpaceX the goal is
to make life multiplanetary um and uh to which which
is you if you go to the the foamy Paradox of where the where are the aliens you got these these sort of great
filters like just like why why have we not heard from the aliens now L lot of people think there are aliens Among Us I
often claim to be one nobody believes me but um it did say alien registration card at one point on my
uh immigration documents um yeah so I've not seen any evidence of aliens so it's suggest that um at least one of the one
of the explanations is that uh intelligent life is extremely rare um and again if you look at the
history of Earth civilization's only been around for one millionth of Earth
existence so if you know if aliens had visited here say 100,000 years ago they would be like well they don't even have
writing you know just hunter gatherers basically so
um so how long does a civilization last so for SpaceX the goal is to establish a self-sustaining City on Mars
Mars is the only viable planet for such a thing um the Moon is close but it's it lacks
resources and I think it's probably vulnerable to any any any Calamity that takes out Earth could the
Moon is too close it's vulnerable to a Calamity that takes out Earth um so not saying we shouldn't have a moon base but
Ms is Ms would be far more resilient um the difficulty of getting to Ms is what makes it
resilient um so but and you know in going through the these various explanations of why
don't we see the aliens why one of them is that they they failed to pass these these great filters these
these key hurdles and one of those hles is being a multiplet
species um so if you're multiplet species and if something would happen whether that was a natural catastrophe
or a man-made catastrophy at least the other planet would probably still be around so you're not like you don't have
all the eggs in one basket and once you are sort of a two Planet species you can obviously extend
to extend life paths to the asteroid belt to maybe to the moons of Jupiter and
Saturn um and ultimately to other star systems but if you can't even get to another planet you definitely not
getting to Star systems and the other possible great field there uh super powerful technology like AGI for example
So you you're basically trying to knock out one great filter at a time digital superintelligence is
possibly a great filter I hope it isn't but it might be you know guys like say Jeff Hinton would say
you know has he invented a number of the key principles in artificial intelligence I think he puts the
probability of AI Anni Annihilation around 10 to 20% something like that
so you know so it's it's not uh like you know look on the right side it's a 80% likely to be
great so so but I I think AI risk mitigation is important um being a multi species would be a massive risk
mitigation and um I I do want to sort of once again emphasize this import the importance of having enough children to
sustain um our numbers um and not going not plummet into population collapse which is
currently happening po population collapse is a real and current thing um so the the only reason it's not being
reflected in the total population numbers is that is that as much is because people are living
longer um but but you you you can it's easy to predict say what the population of Any Given country will be um you just
take the birth rate last year how many VES were born multiply that by life expectancy and that's what the
population will be a steady state unless if if the birth rate continues to that level but if it keeps declining it
will be even less and eventually dwindle to nothing so I keep you know banging on the baby drum here um for a reason um
because it has been the the source of civilizational collapse over and over again throughout history um and
so why don't we just uh not try to stable for that day well in that way I have miserably failed civilization and
I'm trying hoping to fix that I would love to have many kids uh great I hope you
do um no time like the present yeah yeah I got to allocate more compute to the whole process um but apparently
it's not that difficult no it's like unskill Labor uh well if I one of the things uh
you do for me for the world is to inspire us with what the future could be and so some of the things we've talked
about some of the things you're building um alleviating human suffering with neuralink and expanding the capabilities
of the human mind trying to build the colony on Mars um so creating a backup for
Humanity on on another planet and uh exploring the possibilities of what artificial intelligence could be in this
world especially in the real world AI with uh hundreds of millions maybe billions of robots walking around there
will be billions of robots that's uh that seems one that seems virual certainty well thank you for building
the future and thank you for inspiring so many of us to keep building and creating cool stuff including kids yeah
you're welcome uh go forth and multiply go forth and multiply thank you Yan thanks
for talking brother thanks for listening to this conversation with Elon Musk and now dear friends here's DJ saw the
co-founder president and CEO of neolink when did you first become fascinated by the human brain for me I
was was always interested in understanding the purpose of things and how it was engineered to serve that
purpose whether it's organic or inorganic you know like we were talking earlier about your curtain
holders they serve a clear purpose and they were engineered with that purpose in
mind and you know growing up I had a lot of interest in seeing things touching things feeling
things and trying to really understand the root of how it was designed to serve that purpose and you know obviously
brain is just a fascinating organ that we all carry it's a infinitely powerful machine that has Intelligence and
cognition that arise from it and you know we we haven't even scratched the surface in terms of how all of that
occurs but also at the same time I think it took me a while to make that connection to really studying and
building Tech to understand the brain not until graduate school you know there were a couple moments key moments in my
life where some of those I think influence how the trajectory of My Life um got me to studying uh what I'm doing
right now you know one was growing up both sides of my family uh my grandparents had a very severe form of
Alzheimer and it's um you know incredibly debilitating conditions um I mean
literally you're seeing someone's whole identity and and their mind just losing over time and I I just remember thinking
um how both the power of the mind but also how something like that could really lose your sense of identity it's
fascinating that that is one of the ways to reveal the power of a thing by watching
it lose the power yeah a lot of what we know about the brain actually comes from uh these cases where uh there are trauma
to the brain or some parts of the brain that led someone to lose certain abilities and as a result there's
some correlation and understanding of that part of the tissue being critical for that function and um it's an
incredibly fragile organ if you think about it that way but also it's incredibly plastic and Incredibly
resilient in many different ways and by the way the term plastic is will use a bunch means that it's adaptable so
neuroplasticity refers to the the adaptability of the human brain correct um another key moment that sort of
influenced how the trajectory of my life have shaped towards the current focus of my life has been during my teenager when
I came to the US you know I didn't speak a word of English there was a huge language
barrier and um there was a lot of struggle to kind of connect with my peers around me um because I didn't
understand the the artificial construct that we have cre created called language uh specifically English in this case and
I remember feeling pretty isolated not being able to connect with peers around me so spent a lot of time just on my own
you know reading books watching movies um and I I naturally sort of gravitated towards sci-fi books I just found them
really really interesting and also it was a great way for me to learn English you know some of the first set of books
that I picked up are Ender Game you know the whole Saga by uh Orson Scott Card and Neuromancer from William Gibson and
Snow Crash from Neil Stevenson and you know movies like Matrix was coming out around that time point that really
influenced how I think about the potential impact that technology can have for our lives in general so
FastTrack to my college Years you know I I was always fascinated by just just physical stuff building physical stuff
and especially um physical things that had some sort of intelligence and and you know I studied electrical
engineering during undergrad and I started out my research in Ms uh so micro electron mechanical systems um and
really building these tiny Nano structures for um temperature sensing and I just found that to be just
incredibly rewarding and fascinating subject to just understand how you can build some something miniature like that
that again served a function and had a purpose and then you know I I spent large majority of my college Years
basically building millimeter wave circuits for nextg telecommunication systems for Imaging and it was just
something that I found very very intellectually interesting you know phase arays how the the signal
processing works for you know any modern as well as NextGen telecommunication system Wireless and Wireline um EM waves
or electromagnetic waves are fascinating how do you design antennas that are um most efficient in a small footprint that
you have how do you make these things energy efficient that was something that just consumed my intellectual curiosity
and that Journey led me to actually apply to and find myself at PhD program at UC Berkeley at kind of this
Consortium called the Berkeley Wireless Research Center that was precisely looking at um building at the time we
called it XG you know similar to 3G 4G 5G but the next next Generation G system and how you would design circuits around
that to ultimately go on phones and you know basically any any other devices uh that are wirelessly connected these days
um so I I I was just absolutely just fascinated by how that entire system works and that infrastructure Works um
and then also during grad school I had sort of the fortune of having um you know couple research fellowships that
led me to pursue whatever project that I want and that's that's one of the things that uh I really enjoyed about my
graduate school career where you got to kind of pursue do your intellectual curiosity in the domain that may not
matter at the end of the day but is something that you know really uh allows you the opportunity to um go as deeply
as you want as well as as widely as you want and at the time I was actually working on this project called the smart
bandid and the idea was that when you get a wound there's a lot of other kind of proliferation of signaling pathway
that cells follow to close that wound and there were hypothesis that when you apply external electric field
you can actually accelerate the closing of that field by having you know basically electr taxing of the cells
around that wound site and specifically not just for normal wound there are chronic wounds that don't heal um so we
were interested in building you know some sort of a wearable patch that you could
um apply to kind of facilitate that healing process and um that was in collaboration with uh Professor Michelle
Mah haritz um you know which which you know was a great addition to kind of my thesis committee and you know really
shaped rest of my uh PhD career so this would be the first time you interacted with Biology I suppose correct correct I
mean there were some peripheral you know end application of the wireless Imaging and
telecommunication system that I was using for security and bioimaging but this was a very clear direct application
to bio biolog biology and biological system and understanding the constraints around that and really designing and
Engineering electrical Solutions around it so that was my first introduction and that's also um kind of how I got
introduced to Michelle um you know he's he's sort of known for remote control of uh Beatles in the early
2000s and then around 2013 you know obviously kind of the Holy Grail when it comes to implant system is
to kind of understand how small of a thing you can make and a lot of that is driven by how much energy or how much
power you can supply to it and how you extract data from it so at the time at Berkeley there was kind of this this uh
desire to kind of understand in the neural space what what what sort of system you can build to really
miniaturize these implantable systems and uh I distinct distinctively remember this one uh particular meeting where
Michelle came in and he's like guys I think I have a solution the solution is
ultrasound and uh and then he proceeded to kind of walk through why that is the case and that that really formed the
basis for my thesis work um uh called neural dust system that was looking at ways to use ultrasound as opposed to uh
electromagnetic waves for powering as well as communication I guess I should step back and say the the initial goal
of the project was to build these tiny about a size of a neuron implantable system that can be parked
next to a neuron being able to record its state and being able to Ping that back to the outside world for doing
something useful you know as I mention the size of the implantable system is limited by how you power the thing and
get the data off of it and at the end of the day fundamentally if you look at a human body where uh
essentially bag of salt water with some interesting proteins and chemicals but uh it's mostly salt water that's very
very well temperature regulated at 37° c um and we'll we'll get into how why and and later why that's a an extremely
harsh environment for any Electronics to survive as I'm sure you've experienced or maybe not experienced you know
dropping cell phone in a in a salt water in an ocean it will instantly kill the device right um but anyways uh just in
general electromagnetic waves don't penetrate through this environment well um
and just the speed of light it is what it is we can't we can't change it and based on the um the wavelength at which
you are interfacing with the device it the device just needs to be big like these inductors needs to be quite big um
and the general good rule of thumb is that you want the wavefront to be roughly on the order of of the size of
the thing that you're interfacing with so an implantable system uh that is around 10 to 100 Micron in dimension in
in in a volume which is about the size of a neuron that you see in um in a human body um you would have to operate
at like hundreds of gigahertz which number one not only is it difficult to build Electronics operating at those
frequencies but also the body just attenuates that very very significantly so the interesting kind of insight of
this ultrasound um was the fact that ultrasound just travels a lot more effectively in the human body tissue
compared to electromagnetic waves and this is something that you encounter uh and you I'm sure most
people have encounter in their lives when you go to um you know hospitals that are medical uh ultrasound you know
sonograph right um and they go into very very deep depth without attenuating too much too much of the signal so all in
all you know we'll just sound the fact that it travels through the body extremely well and the mechanism to
which it travels to the body really well is that just the wavefront is very different it's uh electromagnetic waves
are transverse whereas in ultrasound waves are compressive so it's just a completely different mode of uh
wavefront propagation um and as well as speed of sound is orders and Orders of magnitude less than speed of light which
means that even at 10 megahertz ultrasound wave your wavefront ultimately is a very very small
wavelength so if you're talking about interfacing with the 10 Micron or 100 Micron type
structure you would have 150 Micron wave front at 10 MHz and building electronics at those Mega uh at those frequencies
are much much easier and they're a lot more efficient so the basic idea kind of was born out of um you know using
ultrasound as a mechanism for powering the device and then also getting data back so now the question is how do you
get the data back the mechanism to which we landed on is what's called back scattering um this is actually something
that is very common and that we interface on a day-to-day basis with our RFID cards you know our radio frequency
ID tags where there's actually rarely you know in your ID a battery inside there's an antenna
and there's some sort of uh coil that has your serial uh identification ID and then there's an external device called
the reader that then sends a wavefront and then you reflect back that wavefront with some sort of modulation that's
unique to your ID that's that's what's called back scattering uh fundamentally so the tag itself actually doesn't have
to cons consume that much energy and um that was a mechanism to which we were kind of thinking about sending the data
back so when you have an external uh ultrasonic transducer that's sending ultrasonic wave to your implant the
neural dust implant and it records some information about its environment whether it's a neuron firing or uh some
other state of um the uh the tissue that it's interfacing with and then it just
amplitude modul the wfront that comes back to the source and the recording step would be the only
one that requires any energy so what would require energy in that little step correct so it it is that initial kind of
startup circuitry to get that recording amplifying it and then just modulating MH and the mechanism to which that that
you can enable that is there is the specialized Crystal called p Electric crystals that are able to convert Sound
Energy into electrical energy and vice versa so you can kind of have this inter interplay between the ultrasonic domain
and electrical domain that is the the biological tissue so on the theme of parking very
small computational devices next to neurons that's the dream uh the vision of brain computer interfaces maybe
before we talk about neuralink can you give a sense of the history of the field of BCI what what has been um maybe the
continued dream and also some of the Milestones along the way with the different
approaches and the amazing work done at the various Labs I think a good starting point is um
going back to 1790s I did not expect that where um the concept
of animal electricity or the fact that B's electric was first discovered by Luigi gbani where uh he had this
experiment where he connected set of electrodes to frog leg and ran current through it and then it started twitching
and he said oh my goodness body's electric yeah so fast forward many many years to 1920s uh where hansberger who's
a German psychiatrist discovered EEG or Electro inspographic arrays that you wear outside the skull
that gives you some sort of neural recording that was a very very big milestone that you you you can record
some sort of activities about the human mind and then in the 1940s there were uh these group of scientists Rena Forbes
and Morrison that um inserted these glass micro electrodes into the cortex and recorded single
neurons um the fact that they they there's signal that are a bit more high resolution and high Fidel
uh as you get closer to the source let's say and in the 1950s um these two scientists hodkin and hawkley showed up
and they um built this beautiful beautiful models of the cell membrane and the ionic mechanism and had these
like circuit diagram and as as someone who's an electro engineer it's a beautiful model that's you know built
out of these uh partial differential equations talking about flow of ions and how that really leads to how neurons
communicate and they won the Nobel Prize for that 10 years later in the 1960s so in
1969 uh F fets from University of Washington published this beautiful paper called oper and conditioning of
cortical unit activity where he was able to record a single unit neuron from a monkey and was able to have the monkey
modulated based on its activity and reward system so I would say this is the very very first example um as far as I'm
aware of Clos Loop uh you know brain computer interface or BCI the abstract reads the activity of single neurons in
precentral cortex of anesthesized monkeys was conditioned by reinforcing High rates of neuronal discharge with
delivery of a food P auditory and visual feedback of unit firing rates was usually provided in addition to food
reinforcement cool so they actually got it done they got it done this is um back in
1969 after several training sessions monkeys could increase the activity of newly isolated cells by 50 to 500% above
rates before reinforcement fascinating brain is very
plastic and so and so from here the number of experiments grew yeah number of experiments as well
as set of tools to interface with the brain have just exploded um I think and also just understanding the neural code
and how some of the cortical layers and and the functions are organized so the other paper that is um uh pretty seminal
especially in the the motor decoding uh was this paper in the 1980s from Georgia opis um that discovered that there's
this thing called motor tuning curve so what are motor tuning curves it's the fact that there are you know neurons in
the motal cortex of mammals including humans that have a preferential direction that causes them to fire so
what that means is there are a set of neurons that would uh increase their spiking activities when you're thinking
about moving to the left right up down and any of those uh vectors and based on that you know you could start to think
well if you if you can't identify those essential igon detectors you can do a lot and you can actually use that
information for actually decoding someone's intended movement from the cortex so that was a very very seminal
kind of paper that showed um that uh there there is some sort of code that you can you can extract especially in
the motor cortex so there's signal there and if you measure uh the the electrical signal from the brain that you could you
could actually figure out what the intention was correct yeah not only electrical signals electrical signals
from the right set of neurons that give you this preferential Direction okay so going slowly towards
neuralink uh one interesting question is what do I understand on the BCI front on invasive versus noninvasive from this
line of work uh how important is it to to park next to the neuron what does that get you that answer fundamentally
depends on what you want to do with it right um there's actually incredible amount of stuff that you can do with EEG
and um electrograph ecog which actually doesn't penetrate the the cortical layer or panoma um but you place a set of
electrodes on the surface of the brain so the thing that I'm personally very interested in is just actually
understanding um and and being able to just really tap into the high resolution High Fidelity
understanding of the activities that are happening at the local level and you know we can get into biophysics
but just to kind of step back um to kind of use analogy because analogy here can be useful sometimes it's a little bit
difficult to think about electricity um at the end of the day we're doing electrical recording that's mediated by
ionic um currents you know movements of these charged particles um which is really really hard for most people to
think about um but turns out a lot of the activities um that are happening in the brain and
the frequency band with which that's happening is actually very very similar to sound waves and and you know our
normal conversation um audible L range so the analogy that typically is used in the field is you if you if you have a
football stadium uh you know there's game going on if you stand outside the stadium you
you maybe get a sense of how the game is going based on the cheers and the booze of the home crowd whether the team is
winning or not but you have absolutely no idea what the score is you have absolutely no idea what um individual
audience or the players are talking or saying to each other what the next play is what the next goal is um so what you
have to do is you have to drop the microphone near into the stadium and then get near the source like into the
individual chatter um in this specific example you would want to have it you know right next to where the Huddle is
happening M um so I I think that's kind of a good illustration of what we're trying to do um when we say
invasive or minimally invasive or implanted brain computer interfaces versus noninvasive or non-implanted uh
brain interfaces it's basically talking about where do you put that microphone and what can you do with that
information so what what is the biophysics of the read and write communication that we're talking about
here as we now step into the efforts at neur link yeah so uh brain is made of of these specialized cells called neurons
there's billions of them you know tens of billions you know sometimes people quote 100 billion that are connected in
this complex yet Dynamic network uh that are constantly remodeling you know they're changing their synaptic weights
um and that's you know what we typically call neuroplasticity and the neurons are also
bathed in this charged environment that is Laten with many charge molecules like potassium ions sodium ions chlorine ions
and uh those actually facilitate these um you know through ionic current communication between these different
networks and uh when you look at the look at a neuron as well um they they have these uh membrane with a beautiful
beautiful uh protein structure called the voltage selective ion channels which in my opinion is one of Nature's Best
inventions in many ways if you think about what they are they're doing the job of a modern-day transistors
transistors are nothing more at the end of the day than a voltage gated conduction Channel um and nature found a
way to have that very very early on in its Evolution and as we all know with the transistor you can have many many
computation and a lot of amazing things um that that we have access to today so I I I I think I it's one of those just
as a tangent just a beautiful beautiful uh invention that the nature came up with these voltage gated ion channels I
mean I suppose there's on the biological level every level of the complexity of the hierarchy of the the organism
there's going to be some mechanisms for storing information and for doing computation and this is just one such
way but to do that with uh biological and chemical components is interesting plus like with neurons I mean it's not
just electricity it's uh chemical communication it's also mechanical I mean these are like actual objects that
have like that vibrate I mean they move yeah there actually I mean there's a lot of really really interesting physics
that that that are involved and you know kind of going back to my um work on ultrasound uh during grad school there
there are groups and uh there were groups and there are still groups um looking at ways to cause neurons to
actually fire an action potential using ultrasound wave and the mechanism to which that's happening is still unclear
as I understand um you know it may just be that you know you're imparting some sort of thermal energy and that causes
cells to depolarize in some interesting ways um but there are also these um ion channels or even membranes that actually
just open up its pore as they're being mechanically like shook right vibrated so there's just a lot of you know
elements of these like move particles um which again like that's governed by diffusion physics right uh
movements of particles and there's also a lot of kind of interesting physics there also not to mention as Roger penos
talks about the there might be some uh beautiful weirdness in the quantum mechanical effects of all of this and he
he actually believes that Consciousness might emerge from the quantum mechanical effects there so like there's physics
there's chemistry there bi all of that is going on there oh yeah yeah I mean you can yes I there's there's a lot of
levels of physics that you can dive into but yeah in the end you have these um uh membranes with these voltage gated ion
channels that selectively let um these charged molecules that are in in The extracellular Matrix like in and out um
and these neurons generally have these like resting potential where there's a voltage difference between inside the
cell and outside the cell and um when there's some sort of stimuli that changes uh the state such that they need
to send information to the the downstream Network um you know you start to kind of see these like sort of
orchestration of these different molecules going in and out of these channels they also open up like more of
them open up once it reaches some threshold uh to a point where you know you have a depolarizing cell that sends
a action potential so it's a just a very beautiful kind of orchestration of these uh these these um
molecules and um what we're trying to do when we place an electrode or parking it next to a neuron is that you're trying
to measure these local changes in the potential um again mediated by uh the the U the movements of the ions and
what's interesting as I as I mentioned earlier there's a lot of physics involved um and and the two dominant
physics for this electrical recording domain is diffusion physics and electromagnetism
and where one dominates where Max Maxwell's equation dominates versus fix law dominates depends on where your
electrode is um if it's close to the source uh mostly electromagnetic based um when you're further away from it it's
more diffusion based so essentially when you're able to park it next to it you can listen in on those
individual chatter um and those local changes in the potential and the type of signal that you get are these canonical
textbook neural uh spiking waveform when you're the moment you're further away and based on some of the studies that
people have done um you know Kristoff C's lab and and others once you're away from that Source by roughly around 100
Micron which is about a width of a human hair you no longer hear from that neuron you you're no longer able to kind of
have the system sensitive enough to be able to um record that particular um local membrane potential change in that
neuron and just to kind of give you a sense of scale also when you when you look at a 100 Micron voxal so 100 Micron
by 100 Micron by 100 Micron box uh in a brain tissue there's roughly around 40 neurons and whatever number of
connections that they have so there's lot in that volume of tissue so the moment you're outside of that you're
there's just no hope that you'll be able to D detect that change from that one specific neuron that you may care about
yeah but as you're moving about this space you'll be hearing other ones so if you move another 100 Micron you'll be
hearing chatter from another Community correct and so the the whole senses you want to place as many as possible
electrodes and then you're listening to the chatter yeah you want to listen to the chatter and and at the end of the
day you also want to basically let the software do the do the job of decoding um and um just to kind of go to you know
why EOG and EEG work at all right um when you have these local changes you know obviously it's not just this one
neuron that's uh activating there's many many other networks that are activating all the time and you do see sort of a
general change in the potential of this Electro like this charge medium and that's what you're recording when
you're farther away I mean you you still have some reference Electro that's uh stable and the Brain that's just
electroactive organ and you're seeing some combination aggregate uh action potential changes and then you can pick
it up right it's a much slower um changing uh signals but you know uh there there are these like canonical
kind of oscillations and waves like gamma waves beta waves like when you sleep that that can be detected cuz
there's sort of a syn ionized um kind of global global effect of the brain that that you can detect um and I mean the
physics of this go like I mean if we really want to go down that rabbit hole like there there's a lot that goes on in
terms of like why diffusion physics at some point dominates when you're further away from the source you know it it it's
just a Charged medium um so similar to how when you have electromagnetic waves propagating in atmosphere or in in a
Charged medium like a plasma there's this weird shielding that happens that actually um further
attenuates the signal um as you move away from it so yeah you see like if you do a really really deep dive on kind of
the signal attenuation over distance you start to see kind of 1/ R square in the beginning and then exponential drop off
and that's the knee at which you know you go from electromagnet magnetism dominating to diffusion physics
dominating but once again with the electrodes the the biophysics that you need to
understand is is um not as deep because no matter where you're placing that you're listening to a small crowd of
local neurons correct yeah so once you penetrate the brain um you know you're in the arena so to speak and there's a
lot of neurons there many many of them but then again there's like uh there's a whole field of Neuroscience that's
studying like how the different groupings the different sections of the seating in the arena what they usually
are responsible for which is where the the Met probably falls apart cuz the the seating is not that organized in an
arena also most of them are silent they don't really do much um you know or or they their activities are um you know
you have to hit it with just the right set of stimulus so they're usually quiet they're usually very quiet quiet there's
I mean similar to dark energy and dark matter there's dark neurons what are they all doing when you place these
electrode again like within this 100 Micron volume you have 40 or so neurons like why why do you not see 40 neurons
why do you see only a handful what is happening there well they're mostly quiet but like when they speak they say
profound I think that's the way I'd like to think about it anyway before we zoom in even more let's zoom out so how
does neuralink work from the surgery to the implant to the signal and
the decoding process and the human being able to use the implant actually affect the the world outside and all of this
I'm asking in the context of there's a gigantic historic Milestone that neuralink just accomplished in January
of this year uh putting a neur link implant in the first human being Nolan uh and there's been a lot to talk
about there about his experience because he's able to describe all the nuance and the beauty and the fascinating
complexity of that experience of everything involved but on the technical level how does neuralink work yeah so
there are three major components to the technology that we're building uh one is the device um the thing that's actually
recording these neural Chatters uh we call it N1 implant or the link
and uh we have a surgical robot that's actually doing an implantation of these tiny tiny wires that we call threads
that are you know smaller than uh human hair and um once everything is surged you have these
neural signals these spiking neurons that are coming out of the brain and uh you need to have some sort of software
to decode what the users intend to do with that um so there's What's called the neuralink application or B1 app
that's doing that translation is running the very very simple machine learning model that decodes these um inputs that
are neural signals and then convert it to a set of outputs that allows um you know our participant uh first
participant Nolan to be able to control a cursor and this is done wirelessly and this is done wirelessly so we um our our
implant is actually two-part this the link has uh uh you know these flexible tiny wires called threads um that have
uh multiple electrodes along its length and uh they're only inserted into the cortical layer which is about 3 to 5
millimeters in a human human brain um in the motor cortex region that's where the kind of the intention for movement lies
in and we have 64 of these threads each thread having 16 electrodes along you know the span of 3 to 4 millimet um
separated by 200 Micron so you can actually record along the depth of the insertion and based on that signal uh
there's custom um you know integrated circuit or ASC that we built that amplifies the
neural signals that you're recording and then digitizing it and then um has some mechanism for detecting whether there
was a an interesting event that is a spiking event um and decide to send that or not send that through Bluetooth to an
external device whether it's a a phone or a computer that's running this neuralink application so there's onboard
signal process in already just to decide whether this is an interesting event or not so there is some computational power
on board inside the in addition to the human frame yeah so it does the signal processing to kind of really compress
the amount of signal that you you're recording so we have a total of thousand electrodes um sampling at uh you know
just under 20 khz with 10 bit each so wow uh that's 200 megabits um that's coming through to the chip uh from
thousand uh Channel simultaneous uh neural recording and that's quite a bit of data and you know there is there are
technology available to send that off wirelessly but being able to do that in a a very very thermally constrained
environment that is a brain so there has to be some amount of compression that happens to send off only the interesting
data that you need which in in this particular case for motor decoding is um occurrence of a spike or not and then um
being able to use that to um to uh you know decode the intended cursor movement so the implant itself processes it
figures out whether a spike happened or not with our Spike detection algorithm and then sends it off packages it send
it off through Bluetooth um to an external device that then has the model to decode okay based on the spiking
inputs did Nolan wish to go up down left right or click or right click or whatever all of this is really
fascinating but let's stick on the N1 implant itself so the thing that's in the brain uh so I'm looking at a picture
of it there's an enclosure uh there's a charging coil so we didn't talk about the charging which
is fascinating uh the the battery the Power Electronics the
antenna uh then there's the signal processing Electronics I wonder if there's more
kinds of signal processing you can do that's that's another that's another question and then there's the threads
themselves with the enclosure on the bottom so maybe to ask about the charging so there's a external charging
device mhm yeah there's an external charging device um so yeah the the second part of the implant the threads
are the ones again just the the last 3 to 5 millim are the ones that are actually penetrating the cortex uh rest
of it is actually most of the volume is occupied by the battery uh rechargeable battery um and uh you know it's about a
size of a quarter uh you know I actually have a device here if you want to take a look at
it um you know this is the the flexible thread component of it and then this is
the implant so it's about a size of a US Quarter um it's about 9 mm thick so
basically this implant uh you know once you have the craniectomy and the and the diromy um threads are inserted and and
um the the hole that you created this craniectomy gets replaced with that so basically that thing plugs that hole and
you can screw in uh these self- drilling cranial screws to hold it in place and at the end of the day once you have the
skin flap over uh there's only about 2 to 3 mm that's you know obviously transitioning off of the top of the
implant to where the screws are and and that's the minor bump that you have those threads look
tiny that's incredible that is really incredible that is really incredible and also as you're right most of the volume
actual volume is the battery yeah wow this is way smaller than I realized they they are also the threads themselves are
quite strong they look strong and and the thread themselves also has a very interesting um feature at the end of it
called The Loop and that's the mechanism to which the robot is able to interface and manipulate this tiny hairlike
structure and they're tiny so what's the width of a thread yeah so the the width of a thread um starts from 16 Micron and
then tapers out to about 84 Micron so you know average human hair is about 8200 Micron in
width this thing is amazing this thing is amazing yeah so most of the volume is
occupied by the by the battery rechargeable Li iion cell um and uh the charging is done through inductive
charging which is actually very commonly used you know your cell phone most cell phones have that um the biggest
difference is that you know for us you know usually when you have a phone and you want to charge it on a
charging pad you don't really care how hot it gets whereas for us it matters there's a very strict regulation and
good reasons to not actually increase the surrounding tissue temperature by two degrees Celsius so there's actually
a lot of innovation that is packed into this to allow charging of this implant without causing that temperature
threshold to reach and even small things like you see this charging coil and what's called The farite Shield right so
uh without that fite Shield what you end up having when you have um you know resonant inductive charging is that the
battery itself is a metallic can and you form these Ed currents um from uh external charger and that
causes heating um and that actually contributes to inefficiency in charging um so this ferite Shield what it does is
that it actually concentrate that field line away from the battery and then around the coil
that's actually wrapped around it there's a lot of really fascinating design here to to make it I mean you're
integrating a computer into a biological complex biological system yeah there's a lot of innovation here I would say that
part of what enabled this was just the Innovations in the wearable uh there's a lot of really really powerful tiny low
power uh microcontrollers temperature sensors or various different sensors and Power
Electronics a lot of innovation really came in the the charging coil design how this is packaged and how do you enable
charging such that you don't really uh exceed that temperature limit which is not a constraint for other devices out
there so let's talk about the threads themselves those tiny tiny tiny things so uh how many of them are there you
mentioned a th000 electrodes how many threads are there and what do the electrodes have to do with the threads
yeah so the current instantiation of the device has 64 threads and each thread has 16 electrodes for total of 10,24
electrodes that are capable of both recording and stimulating um and um the thread is basically this
uh polymer insulated wire um the metal conductor is the kind of a tius tiramisu cake of uh Thai plat gold plat Thai um
um and they're very very tiny wires um to Micron in with so two one millionth of uh meter it's crazy that that thing
I'm looking at has the polymer insulation has the conducting material and has 16 electrod at the end of it on
each of those thread yeah on each of those threads correct 16 each one of those you're not going to be able to see
it with naked eyes and I I mean to State the obvious or maybe for people who are just
listening they're flexible yes yes that's also one element that uh was incredibly important for us
um so each of these thread are as I mentioned 16 Micron in width and then they taper to 84 Micron but in thickness
they're less than 5 Micron MH um and in thickness it's mostly you know a poly imid at the bottom and this metal track
and then another poly imid so two Micron of poly imid 400 nanometer of this metal stack
and 2 Micron of poly imid sandwich together to protect it from environment that is uh 37° C bag of salt water so
what what's some maybe can you speak to some interesting aspects of the material design here like what does it take to to
design a thing like this and to be able to manufacture a thing like this uh for people who don't know anything about
this kind of thing yeah so the material selection that we have is not I don't think it was particularly unique um
there there were other labs and there are other labs that are kind of looking at similar um material stack um there's
kind of a fundamental question um and and still needs to be answered around the longevity and reliability of these
uh micro electrodes um that that we call uh compared to some of the other more conventional neural interfaces devices
that are intra cranial so penetrating the cortex that are more rigid um you know like the
utar um that that are these 4x4 millimet kind of silicon shank that have exposed uh recording site at the end of it um
and and um you know that's that's been kind of the Innovation from Richard Norman back in 1997 uh it's called the
Utah R because you know he was at University of Utah and what is the Utah R look like so it's a rigid type of yeah
so we can actually look it up yeah yeah so it's a bed of needle um
there's yeah okay go ahead I'm sorry those are r r shank yeah you weren't kiding and the
size and the number of Shanks vary anywhere from 64 to 128 um at the very tip of it is an exposed electrode that
actually records neural signal um the other thing that's interesting to note is that uh unlike neuralink threads that
have recording electrodes that are actually exposed iridium oxide recording sites along the death this is only at a
single death so these utar spokes can be anywhere between .5 mm to 1.5 mm and they're they also have uh designs that
are slanted um so you can have it inserted at different depth um but that's one of the other big differences
and then uh I mean the main key difference is the fact that uh there's no Active Electronics these are just
electrodes and then there's a bundle of a wire that you're seeing and then that actually then exits the
craniectomy um that then has this port that you can connect to um for any external electronic devices they are
working on a or have the wireless Telemetry device but it still requires a through the skin uh Port that actually
is one of the biggest failure modes for infection uh for the system what is some of the challenges associated with
flexible threads like for example on the robotic side R1 uh implanting those threads how
difficult does that t yeah um yeah so as you mentioned they're they're very very difficult to maneuver by hand um these
these utar rays that you you saw uh earlier they're actually inserted by a neurosurgeon actually positioning it
near the site that they want and then uh they're actually there's a Pneumatic Hammer that actually pushes
them in um so so it's a it's a pretty simple process um and they're easier to maneuver um but for for these thin FM
arrays they're they're very very tiny and uh flexible so they're they're very difficult to maneuver so that that's why
we built an entire robot to do that um there are other other reasons for why we built a robot um and and that is
ultimately we want this to help millions and millions of people that can benefit from this and there just aren't that
many neurosurgeons out there um and uh you know robots can be uh something that you know we hope can actually do large
parts of the surgery um but yeah yeah the the the robot is this entire other um sort of category of product that
we're working on and it it's essentially this multi-axis Gantry system that has the
specialized robot head um that has all of the Optics and um this this kind of a needle retracting mechanism that maners
these these threads um via this Loop structure that you have on the thread so the thread already has
a loop structure by which you can grab it correct correct so this is fascinating so you mentioned Optics so
there's a robot R1 so for now there's a human that actually creates uh a hole in the in the skull and then after that
there's a computer vision component that's finding a way to avoid the blood vessels and then you're grabbing it by
the loop each individual thread and placing it in a particular location to avoid the blood vessels and also
choosing the depth of placement all that so controlling every like the 3D geometry of the placement correct so the
the aspect of this robot that is unique is that it's not surgeon assisted or human assisted it's a semi-automatic or
automatic uh robot once you you know obviously there are human component to it when you're placing Target um you can
always move it away from kind of major vessels that you see um but I mean we want to get to a point
where one click and it just does the surgery within minutes so the computer vision component finds great targets
candidates and the human kind of approves them and the robot does is does it do like one3 at a time or does it do
it does one thread at a time uh and that's that's actually also one thing that we um uh are looking at ways to do
multiple threads at a time there's nothing stopping from it you can have multiple kind of Engagement uh
mechanisms um but right now it's one by one and uh you know we also still do quite a bit of just just kind of
verification to make sure that it got inserted if so how deep you know did it actually match um what was programmed in
and you know so on and so forth and the the actual electros are placed a very at differing depths in the uh like I mean
it's very small differences but differences yeah yeah and so that there's some reasoning behind that as
you mentioned like it it gets more varied signal yeah we I mean we try to place
them all around 3 or 4 millim from the surface um just cuz the span of the electrode those 16 electrod that we
currently have in this uh version spans um you know roughly around 3 mm so we want to get all of those in the
brain this is fascinating okay so there's a million questions here if we go zoom in specific on the electrod so
what is your sense how many neurons is each individual Electro listening to yeah each Electro can record from
anywhere between zero to 40 as I mentioned right earlier um but practically speaking uh we only see
about at most like two to three um and you can actually distinguish which neuron it's coming from by the shape of
the spikes oh cool um so I mentioned the like detection algorithm that we have it's called boss algorithm um
buffer online Spike sorter nice it actually outputs at the end of the day uh six unique values which are um you
know kind of the amplitude of these like negative going Hump Middle hump like uh positive going hump and then also the
time at which these happen and from that you can have a you kind of a statistical probab probability um estimate of is
that a spike is it not a spike and then based on that you could also determine oh that Spike looks different than that
Spike must come from a different neuron okay so that that's a nice signal processing step from which you can then
make much better predictions about if there's a spike especially in this kind of context where there could be multiple
neurons screaming and that that also results in you being able to compress the data
better yeah of day okay that's and just to be clear I mean there the the labs do this what's called Spike sorting um
usually once you have these like Broadband you know like the fully digitized signals and then you run a
bunch of different set of algorithms to kind of tease apart it's just all of this for us is done on the device on the
device in a very low power custom you know built Asic uh digital Processing Unit highly heat constrained highly heat
constrained and the processing time from signal going in and giving you the output is less than a microsc which is
uh you know a very very short amount of time oh yeah so the latency has to be super short correct oh wow oh that's a
pain in the ass yeah latency is this uh huge huge thing that you have to deal with uh right now the biggest source of
latency comes from the Bluetooth uh the the way in which they're packetized and you know we bend them in 15 millisecond
inter communication constraint is there some potential Innovation there on the protocol used absolutely okay yeah
Bluetooth is definitely not uh our final uh wireless communication protocol that we want to get to it's a high H
hence the N1 and the R1 I imagine that increases NX RX uh yeah that's you know the
communication protocol because Bluetooth uh allows you to communicate against farther distances than you need to so
you can go much shorter yeah the only uh well the primary motivation for choosing Bluetooth is that I everything has
Bluetooth all right so you can talk to any devic interoperability is just absolutely essential especially in this
early phase um and in many ways if you can access a phone or a computer you can do
anything it be interesting to step back and actually look at again the same pipeline that you mentioned for Nolan
so what is this whole process look like from finding and selecting a human being to the the to the surgery to the the
first time he's able to use this thing so we have what's called a patient registry that people can sign up to um
you know hear more about the updates and that was a route to which Nolan applied and the process is that once the
application comes in you know it it contains some medical records and we uh you know based on their medical
eligibility that there's a lot of different inclusion exclusion criteria for them to meet and we go through a
pre-screening interview process with someone from neuralink and at some point we also go out to their homes to do a
BCI home audit um because one one of the most kind of revolutionary part about you know having this N1 system that is
completely wireless is that you can use it at home like you don't actually have to go to the lab um and and you know go
to the clinic to get connectorized to these like specialized equipment that you can't take home with you
um so that's one of the the key elements of you know when we're designing the system that we wanted to keep in mind
like you know people you know hopefully would want to be able to use us every day in the comfort of their homes and um
so part of our engagement and and what we're looking for during BCI home audit is to just kind of understand their
situation what other assisted technology that they use and we should also step back and kind of say that uh the
estimate is uh 180,000 people live with quadriplegia in the United States and each year an
additional 18,000 suffer uh a paralyzing spinal cord injury so these are folks uh who have a lot of challenges living life
in terms of accessibility in terms of doing the things that many of us just take for granted dayto day and one of
the things one of the goals of this initial study is to enable them to have sort of digital autonomy where they by
themselves can interact with a digital device using just their mind something that you're calling telepathy so digital
telepathy where uh a quadruple can communicate with a digital device in all the ways that we've been talking
about uh control the mouse cursor enough to be able to do all kinds of stuff including play games and tweet and all
that kind of stuff and there's there's a lot of people for whom life the basics of Life are difficult
uh because of the things that have happened to them so yeah I mean movement is so so fundamental to our ex existence
I mean even even speaking involves movement of mouth lip larynx and um without that it's it's it's um extremely
debilitating um and they're um yeah they're they're many many people that we can help and I mean like especially if
you start to kind of look at other forms of movement disorders um that are not just from spinal cord injury but from uh
you know ALS uh Ms or even stroke that that leads you and or just just aging right that
leads you to lose some of that Mobility that Independence it's uh extremely debilitating and all of these are
opportunities to help people to help alleviate suffering to help improve the quality of life but each of the things
you mentioned is its own little puzzle then you uh to have increasing levels of capability from a device like a neur
link device and so the first one you're you're focusing on is uh it's just a beautiful word telepathy so being able
to communicate using your mind wirelessly with a digital device can you just explain this exactly what we're
talking about yeah I mean it's exactly that I mean I I think if you are able to control a uh cursor and able to click um
and be able to get access to computer or phone I mean the the whole world opens up to you and I mean I guess the word
telepathy if you kind of think about that as um you know just definitionally being able to transfer information from
my brain to your brain um without using some of the the physical faculties that we have you know like voices but the
interesting thing here is I think the thing that's not obviously clear is how exactly it works so in order to move a
cursor mhm there's uh at least a couple ways of doing that so one is you imagine
yourself maybe moving a mouse with your hand mhm or you can then which Nolan talked about like imagine moving the
cursor with your mind like I don't but it's like there is a cognitive step here that's fascinating cuz you you have to
use the brain and you have to learn how to use the brain mhm and you kind of have to figure it out dynamically like
uh because you reward yourself if it works so you're like I mean there's a step that this is it's just a
fascinating step because you have to get the brain to start firing in the right way yeah and you do that by
imagining uh like fake it till you make it and all of a sudden it creates the right kind of signal that if decoded
correctly uh can create the kind of effect and then there's like noise around that you have to figure all of
that out but on the Human Side imagine the cursor moving is what you have to do yeah he says using the force the
force I mean that's isn't that just like fascinating to you that it works like to me it's like holy that actually
works like you could move a cursor with your mind you know as much as you're learning to use that thing that
thing's also learning about you like our our model is constantly up updating the weights to say oh if if someone is
thinking about you know this sophisticated forms of like spiking patterns like that actually means to do
this right so the the machine is learning about the human and the human is learning about the machine so there's
a adaptability to the signal processing the decoding step and then there's the adaptation of noan the human being like
the same way if if you give me a new mouse and I move it I learn very quickly about its sensitivity so I learned to
move it slower mhm and then there's other kind of signal drift and all that kind of stuff they have to adapt to so
both are adapting to each other correct that's a fascinating like software Challenge on both sides the
software on both on the the human software and organic and the inorganic the organic and the inorganic anyway so
sorry to rudely interrupt so there's a selection that Nolan has pass with flying colors um so everything including
that it's a BCI friendly home all of that so what is the the process of the surgery the implantation the first
moment when he gets to use the system the end to end uh you know we say patient in to Patient out is anywhere
between 2 to four hours uh in particular case for n and it was about 3 and 1/ half hours and there's many steps
leading to you know the actual robot insertion right so there's anesthesia induction and we do intraop CT Imaging
to make sure that we're you know drilling the hole in the right location and this is also pre-planned beforehand
um uh someone goes through someone like Nolan would go through fmri and then um they can think about W wiggling their
hand you know obviously due to their injury it's not going to actually lead to um any any sort of intended output
but it's the same part of the brain that lights up when you're imagining moving your finger to actually moving your
finger and that's one of the ways in which we can actually know where to place our threads um because we want to
go into What's called the hand knob area in the motal cortex and you know as as much as possible densely put our Electro
threads um so yeah we do intraop CT Imaging to make sure and double check the location
of the craniectomy and um surgeon comes in does their thing in terms of like skin uh
incision craniectomy so drilling of the skull and then there's many different layers of the brain uh there's What's
called the dura which is a very very thick layer that surrounds the brain that gets actually reective in a process
called dctom and that then expose the pi and the brain that you want to insert and by the time it's been around
anywhere between 1 to 1 and a half hours robot comes in does this thing play placement of the targets inserting of
the thread that takes anywhere between 20 to 40 minutes in the particular case for Nolan was just under or just over 30
minutes and then after that the surgeon comes in there's a couple other steps of like actually inserting the Dural
substitute layer um to protect the thread as well as the the brain and then um yeah screw screw in the implant and
then skin flap and then suture and then you're out so uh where when uh Nolan woke
up what was that like what was the recovery like and when was the first time he was able to use it so he was
actually immediately after the surgery um you know like an hour after the surgery as he was waking up um we did
turn on the device um make sure that we are recording neural signals and we actually did have uh couple signals that
we um noticed that he can actually modulate and what I mean by modulate is that he can think about crunching his
fist and you could see the spike disappear and appear that's awesome um and that was
immediate right uh immediate uh after in in the recovery room how cool is that yeah that's a human being I mean
what that feel like for you this device and a human being a first step of a gigantic journey I mean
it's a historic moment even just that Spike just to be able to to modulate that you know obviously there have been
other other you know uh as you mentioned Pioneers that have participated in these groundbreaking
BCI um you know uh investigational early feasibility studies so we're obviously standing in the shoulders of the Giants
here you know we're not the first ones to actually put electrod in a human human brain um but I I mean just leading
up to the surgery there was uh I I I definitely not sleep I there's just it's the first time that you're working in a
completely new environment um we had a lot of confidence based on our benchtop testing uh or pre-clinical R&D studies
that the mechanism the threads the insertion all that stuff is is very safe and that it's um uh you obviously ready
for uh doing this in a human but there's still a lot of unknown Unknown about can the needle actually insert uh I mean I
we brought something like 40 needles just in case they break and we ended up using only one um but I mean that that
was a level of just complete unknown right because it's a very very different environment and uh I mean that's that's
why we do clinical trial in the first place to be able to test these things out so extreme nervousness and uh just
just I many many sleepless night leading up to the surgery and and definitely the day before the surgery and it was an
early morning surgery like we we started at 7:00 in the morning um and and by the time it was around 10:30 it was it was
it was everything was done but I mean first time seeing that well number one just just huge
relief um that this thing is um you know doing what it's supposed to do um and two I mean just immense amount of
gratitude for for Nolan and his family and then many others that have applied and that we've spoke to and will speak
to are I mean true Pioneers in in every every war and you know I sort of call them the neural astronauts or neurona
neurona yeah um you know these amazing just like in the 60s right like the these amazing just Pioneers right um
exploring the unknown outwards in this case is inward um but incredible amount of gratitude for them to uh you know
just just participate and and play a part um and and it's a it's a journey that we're
embarking on together um but also like I think it was just a that was an very very important Milestone but our work
was just starting so a lot of just kind of uh anticipation for okay what's what needs to happen next uh what a set of
sequences of events that needs to happen for us to you know make it worthwhile for um uh you know both Nolan as well as
us just a linger on that just a huge congratulation to you and the team for that Milestone I know there's a lot of
work uh left but that that is that's really exciting to see there's um that's a source of hope this first big
step opportunity to help hundreds of thousands of people and then maybe uh expand the realm of the possible for the
human mind for millions of people in the future so it's it's really exciting so like the the
opportunities are all ahead of us and to do that safely and to do that effectively was uh was really fun to see
as an engineer just watching other Engineers come together and do an epic thing that was awesome so huge congrats
thank you thank you it's um yeah could not have done it without the team and um yeah I mean that that's the other thing
that I I um you know told the team as well of just this immense sense of optimism for the future um I mean it was
a it's a very important moment for for the company um you know needless to say as well as um you hopefully for many
others out there that we can help so speaking of challenges neur link published a blog post describing that
some of the threads are tracted and so the performance as measured by bits per
second dropped at first but then eventually was regained and that the whole story of how it was regained is
super interesting that's definitely something I'll talk to uh to Bliss and to Nolan about um but in general um can
you speak to this whole experience how is the performance regained and um just the the technical aspects of uh
the threads being retracted and moving the main takeaway is that in the end the performance have come back and it's
actually gotten better than it was before um he's actually just beat the world record yet again last week um to
8.5 BPS so I mean he's he's just cranking and he's just improving the previous one was that he set was eight
correct he said 8.5 yeah the previous world record uh in human was 4.6 yeah so it's uh almost double yeah and his goal
is to try to get to 10 which is rough roughly around kind of the median neural Linker uh using a a you know Mouse with
the hand so it's um it's getting there so yeah so the the performance was regained yeah better than before so that
that's you know a a story on its own of what took the BCI team to recover that performance it was it was actually
mostly on kind of the signal processing and so you know as I mentioned we were um kind of looking at these Spike
outputs from the um our electrodes and what happened is that kind of uh four weeks into the surgery uh we noticed
that the threats have slowly come out of the brain and the way in which we noticed this at first obviously is that
uh well I think Nolan was the first to notice that his performance was degrading um and I think at the time we
were also trying to do bunch of different experimentation um you know different algorithms different um sort
of UI ux so it was expected that there will be variability in the performance um but we did see kind of a steady
decline and then also the way in which we measure the health of the electrod or whether they're in the brain or not is
by measuring uh imp of the electrode so we look at kind of the interfacial um kind of the the the
Randle circuit they they say um you know the capacitance and the and the um the resistance between the electr Surface
and the medium and if that changes in some dramatic ways we have some indication or if you're not seeing
spikes on those channels you have some indications that something's happening there and what we notice is that looking
at those impedence plot and Spike rate plots and also because we have those electrodes recording along the death you
were seeing some sort of movement that indicated that threads were being pulled out um and that obviously will have an
implication on the model side because if you're the number of inputs that are going into the model is changing because
you have less of them um the out that that model needs to get updated right and
um but but there were still signals and as I mentioned similar to how even when you place the signals on the surface of
the bra of the brain or farther weight like outside the skull you still see some useful signals um what we started
looking at is not just the spike occurrence through this boss algorithm that I mentioned um but we started
looking at just the the the power of the frequency band that is um interesting for uh Nolan or Nolan to be able to
modulate so once we kind of change the algorithm for the implant to not just give you the boss output but also these
uh band power output um that helped us sort of refine the model with the new set of inputs and that that was the
thing that really ultimately gave us the performance back um you know in terms of and obviously like the the thing that
we want ultimately and the thing that we are working towards is figuring out ways in which we can keep those threads
intact um for as long as possible so that we have many more channels going into the model that's that's by far the
number one priority that the team is currently embarking on to understand how to prevent that from happening um the
thing that I will say also is that you know as I mentioned this is the first time ever that we're putting these
threats in in a human brain and you know human brain just for a size reference is 10 times out of the monkey brain or the
Sheep brain and it it's um just a very very different environment it moves a lot more it like actually moved a lot
more than we expected um when we uh did did Nolan surgery and um it's uh just a very very different environment than
what we're used to and this is why we do clinical trial right we we we want to uncover some of these uh issues uh and
and failure modes earlier than later so in many ways it's provided us with this enormous amount of data and um
information to be able to uh solve this and this is something that neuralink is extremely good at once we have set of
clear objective and Engineering problem we have enormous amount of talents across many many disciplines to be able
to come together and fix the problem very very quickly but it sounds like one of the fascinating challenges here is
for the system and the decoding side to be adaptable across different time scales so whether it's movement of
threads or different aspects of signal drift sort of on the software of the human brain something changing
like Nolan talks about cursor drift they could be corrected and there's a whole ux challenge to how to do that so it
sounds like adaptability is like a fundamental property that has to be engineered in it is and and I mean I
think I I mean as a company we're extremely vertically integrated um you know we make these thin filam arrays in
our own uh microfab yeah there's uh like you said built-in house this whole paragraph here
from this blog post is pretty gangster uh building the Technologies described above has been no small feat and there's
a bunch of links here that I recommend people click on WE constructed in-house microfabrication capabilities to rapidly
produce various iterations of thin film arrays that constitute our electrode threads we created a custom ftoc laser
Mill manufact your components with micr level Precision I think there's a tweet associated with this that's a whole
thing that we can get into yeah this this okay what are we what are we looking at here this thing this is uh so
in less than 1 minute our custom made ftoc laser Mill Cuts this geometry in the tips of our needles so we're looking
at this weirdly shaped needle the tip is only 10 to 12 microns in width only slightly
larger than the diameter of a red blood cell the small size allows threats to be inserted with minimal damage to the
cortex Okay so what's interesting about this geometry so we're look at this just geometry of a
needle this is the needle that's engaging with the loops in the thread mhm so they're the ones that um you know
thread the thread the loop um and then peel it from the Silicon backing and then this is the thing that gets
inserted into the tissue and then this pulls out leaving the thread and this kind of a notch or the shark tooth that
we used to call uh is the thing that actually is um grasping the loop and then it's it's
designed in such way such that when you when you pull out leavs the loop and the robot is controlling this needle correct
so this is actually housed in a canula and basically the robot is has a lot of Optics that look for where the loop is
um there's actually a 405 nanometer light that actually causes the poly to fluores so that you can locate the the
location of the loop um lights up yeah yeah they do it's a micron Precision process what's interesting about the
robot that it takes to do that that's that's pretty crazy that's pretty crazy that a robot is able to get this kind of
precision yeah our robot is quite heavy um our current version of it um there's I mean it's it's like a giant granite
slab that weighs about a ton um because it needs to be sensitive to vibration environmental vibration and then as the
head is moving at the speed that it's mov moving you know there's a lot of kind of motion control to make sure that
you can achieve that level of precision um a lot of Optics that kind of zoom in on that um you know we're working on
next generation of the robot that is lighter easier to transport I mean it is a it is a feat to move the robot to and
it's far superior to a human surgeon at this time for this particular task absolutely I mean let alone you try to
actually thread a loop in a in a a sewing kit I mean this is like we're talking like fractions of human hair
these these things are it's it's not visible so continuing the paragraph we developed novel hardware and software
testing system such as our accelerated lifetime testing racks and simulated surgery environment which is pretty cool
to stress test and validate the robustness of our Technologies We performed many rehearsals of our
surgeries to refine our procedures and make them um second nature this is pretty
cool we practice surgeries on proxies with all the hardware instruments needed in our mock or in the engineering space
this helps us rapidly test and so there's like proxies yeah this proxy is super cool actually so there's a 3D
printed skull from the images that is taken at Barrow as well as this uh hydrogel mix you know sort of synthetic
polymer thing that actually mimics the the mechanical properties of the brain um it also has vasculature of the person
um so basically what we're talking about here and there's a lot of work that has
gone into making this set proxy that um you know it's about like finding the right concentration of these different
synthetic polymers to get the right set of consistency for the needle Dynamics you know as they're being inserted but
we practice this surgery with the person you know Nolan's basically physiology and brain um many
many many times prior to actually doing the surgery every every step every step every step yeah like where does someone
stand like I mean like you looking at is the picture this is in in in our office of this kind of corner of the robot
engineering space that we you know have created this like mock or space that looks exactly like what they would
experience all the staff would experience during their actual surgery so I mean it's just kind of like any
dense rehearsal where you know exactly where you're going to stand at what point um you just practice that over and
over and over again with an exact anatomy of someone that you're going to surger eyesee and and it it got to a
point where a lot of our Engineers when we created a craniectomy they're like ah that that looks very
familiar we've seen that before yeah man there's wisdom you can gain through doing the same thing over and over and
over it's like a jro Dreams of Sushi kind of thing um because then um it's like
Olympic athletes visualize uh the Olympics and then once you actually show up it feels easy it
feels like any other day it feels Almost Boring winning the gold medal cuz you You' visualized this so many times
you've practiced this so many times that nothing bothers in you it's boring you win the gold medal is boring and the
experience they talk about is mostly just relief probably that they don't have to
visualize it anymore yeah the power of the mind to visualize and where I mean there's a whole whole feel that studies
where muscle memory lies in cerebellum yeah it's incredible uh I think there a good place
to actually ask sort of the big question that people might have is how do we know
every aspect of this that you describe is safe at the end of the day the goal standard is to look at the tissue um you
know what sort of trauma did you cause the tissue and does that correlate to whatever behavioral anomalies that you
may have seen um and that's the language to which uh we we can communicate about the safety of you know inserting
something into the brain and what type of trauma that you can cause so um we actually have an entire department uh
Department of pathology that looks at these uh tissue slices there are many steps that are involved in in doing this
once you have um you know studies that are launched to uh with with particular end points in mind you know at some
point you have to euthanize the animal and then uh you go through necropsy to kind of collect the brain tissue samples
um you know you fix them in formalin and you like gross them you section them and you look at individual slices just to
see what kind of reaction or lack thereof exists so that's the kind of the language to which FDA speaks and you
know as well for us to kind of evaluate the safety of the insertion mechanism as well as the threats um at various
different time points you know both acute um so anywhere between you know uh zero to three months to Beyond three
months so those the kind of the the details of an extremely high standard of safety that has to be reached correct um
FDA supervises this but there's in general just a very high standard and every aspect of this including the
surgery I think U Matthew McDougall has mentioned that like the standard is uh let's say how to put politely higher
than maybe some other operations that we take for granted so the the standard for all the surgical stuff here is extremely
high very high I mean it's a highly highly regulated environment um with you know the governing agencies that
scrutinize every every medical device that gets marketed and I think I think it's a good thing um you know it's good
to have those high standards and we we try to hold extremely high standards um to kind of understand what's sort of
damage if any these uh Innovative emerging Technologies and new technologies that we're building our and
you know so far I I we have been extremely impressed by lack of immune response from these threats speaking of
which you uh you talked to me uh with excitement about the histology and some of the images uh that you're able to
share uh can you explain to me what we're looking at yeah so what you're looking at is stain
tissue image um so this is a sectioned a tissue slice from an animal that was implanted for seven months so
kind of a chronic time point and you're seeing all these different colors and each color indicates specific types of
cell types so purple and pink are astrocytes and microa respectively they're type of uh gal cells and yeah
the the other thing that you know people may not be aware of is your brain is not just made up of soup of neurons and
axons there are other uh you know cells like uh gal cells that actually kind of is the glue and also uh react uh if if
there any trauma or damage to the tissue but the brown are the neurons here the brown are the neurons neurons nuclei so
so what you're seeing is in in this kind of macro image you're seeing these like Circle highlighted in white the
insertion sight and uh when you zoom into one of those you see the threads and then in this particular case I think
we're seeing about the 16 uh you know wires that are going into the page and the incredible thing here is the fact
that you have the neurons that are these Brown structures or brown circular or elliptical thing that are actually
touching and abing the threats so what this is saying is that there's basically zero trauma that's caused during this
insertion and with these neural interfaces these um micro electros that you insert that is one of the most
common mode of failure so when you insert these threads like the utar It causes neuronal Death Around the site
because you're inserting a foreign object right and that kind of elicit these like immune response through
microglia and asites they form this like protective layer around it oh not only are you killing the neuron cells but
you're also creating this protective layer that then basically prevents you from recording neural signals because
you're getting further and further away from the neurons that you're trying to record and that that is the biggest mode
of failure and in this particular example in that inset it's you know it's about 50 Micron with that scale bar the
neurons are just seem to be attracted to it and so there's certainly no trauma that's such a beautiful image by the way
just the so the brown or the neurons and for some reason I can't look away it's really cool and and the way
that these things like I mean your tissues generally don't have these beautiful colors um this is uh Multiplex
stain that uses these different uh protein that are staining these at different colors you know we use very
standard set of um you know staining techniques with HG ea1 and you know new um and and GAP so if you go to the next
image this is also kind of illustrates the second point because you can make an argument and initially when we saw the
the previous image we said oh like are the threads just floating like what is happening here like are we actually
looking at the right thing so what we did is we did another stain and this is all done in-house of this M's uh TR
Chrome stain which is in blue that shows these collagen layers so the blue basically like you don't want the blue
around the the implant threads CU that means that there's some sort of scarring that's happen and what you're seeing if
you look at individual threads is that you don't see any of the blue which means that there has been
absolutely or very very minimal to a point where it's not detectable amount of trauma in these inserted threads so
that presumably is one of the big benefit because of having this kind of flexible thread this yeah so we think
this is uh primarily due to uh the size as well as the flexibility of the threats also the fact that R1 is
avoiding vasculature so we're not disrupting or we're not um causing damage to uh the vessels and not
breaking any of the bloodb brain barrier uh has you know basically caused the immune response to be muted but this is
also a nice illustration of the size of things so this is the tip of the thread yeah those are neurons they're they're
and they're neurons and there and this is the thread listening and the electrodes are positioned how yeah so
this is what you're looking at is not electrod themselves those are the conductive wires so each of those should
probably be two Micron in width um so what we're looking at is we're looking at the chral slice so we're looking at
uh some slice of the tissue so as you go deeper you know you will obviously have less than less uh of the tapering of the
of the thread um but yeah the the point basically being that there's just uh kind of cells around the insert aite
which is um just an incredible thing to see I've just never seen anything like this how easy and safe is it to remove
the implant yeah so it depends on when um in the first 3 months or so after the
surgery um there there's a lot of kind of tissue modeling that's happening you know similar to when you get a cut um
you know you obviously uh you know start over first couple weeks or depending on the size of
the wound um Scar Tissue forming right they're these like contracted and then in the end they turn into scab and you
can scab it off the same thing happens in the brain and it's a very Dynamic environment and before the scar tissue
or the neom membrane or the you know new membrane that forms it's quite easy to just pull them out um and there's
minimal trauma that's that's uh caused during that once the scarf tissue forms and you know with with Nolan as well we
believe that that's the thing that's currently anchoring the threads so we haven't seen any more movements since
then um so they're they're quite stable um it's it's it gets harder to actually completely extract the threads
so our current method for uh removing the device is cutting the thread leaving the the tissue intact
and then unscrewing and taking the implant out and that hole is now going to be plugged with either another
neuralink or uh just with the you know kind of a a peak based you know plastic based uh cap is it okay to leave the
threads in there forever yeah we think so we we've done studies where um you know we left them
there and one of the biggest concerns that we had is like do they migrate and do they get to a point where they should
not be we haven't seen that again once the scar tissue forms they get anchored in place and I I should also say that
you know when we say upgrades like it it's not we're not just talking in theory here like we've actually upgraded
many many times um most of our uh monkeys or non-human primates nhp have been upgraded you know pager who you saw
playing mine pong has the latest version of the device since two years ago and is seemingly very happy and healthy and
fat so what's uh designed for the future the upgrade procedure so uh maybe uh for Nolan what what would the upgrade look
like it was essenti what you're mentioning is there a way to upgrade sort of the device internally where you
take it apart sort of uh keep the capsule and upgrade the internals yeah so there there a couple different things
here so for Nolan if we were to upgrade what we would have to do is um either cut the threads or you know extract the
threads depending on kind of um you know uh the situation there in terms of how they're anchored or scarred in um if you
were to remove them with the Dural substitute um you know you have an intact brain so you can reinsert
different threads um with the updated uh implant package uh there are couple
different other uh ways that we're thinking about the future of what the upgradeable system looks
like one is you know at the moment we currently remove the dura um this this kind of thick layer that protects the
the brain but that actually is a thing that actually proliferates the scar tissue formation so typically the
general good rule of thumb is you want to leave the the nature as is uh and not disrupt it as much so we're looking at
ways to uh insert the threads through the dura um which comes with different set of challenges such as
you know it's a pretty thick uh layer so how do you actually penetrate that without breaking the needle so we're
looking at different needle design for that as well as the kind of the loop engagement the other biggest challenges
are it's quite opaque optically in with white light illumination so how do you avoid still this this biggest advantage
that we have of avoiding basc Shure U how do you image through that how do you actually still mediate that so there are
other Imaging techniques that we're looking at to enable that um but the goal the our hypo IIs is that and based
on some of the early evidence that we have uh doing through the dura insertion will cause minimal scarring that causes
them to be much easier to extract over time and the other thing that we're also looking at this is um going to be a
fundamental change in the implant architecture is as a at the moment it's a monolithic single implant that comes
with a thread that's um bonded together so you can't actually separate the thing out but you can imagine having two-part
implant um you know bottom part that is the thread that are inserted that has the chips um and maybe a radio and some
power source and then you have another implant that has more of the computational heavy load and and the
bigger battery um and then one can be under the D one can be above the D like you know being the plug for the skull
they can talk to each other but the thing that you want to upgrade the computer and not the threads if you want
to upgrade that you just go in there you know remove the screws and then put in the next version and you know you're off
the you know it's a very very easy surgery too like you do a skin incision slip this in screw probably be able to
do this in 10 minutes so that would allow you to reuse the threads sort of correct so I mean this leads to the
Natural question of uh what is the pathway to scaling the increase in the number of threads is that a priority is
that like what's what's the technical uh challenge there yeah that that is a priority so for next versions of the
implant um you know the key metrics that we're looking to improve are number of channels just recording from more and
more neurons um you know we have a pathway to actually go from currently 1,000 to you know hopefully 3,000 if not
6,000 by end of this year um wow and then end of next year we want to get to uh you know even more 16,000 wow there a
couple limitations to that one is you know obviously being able to photo lithographically print those wires as I
mentioned it's two Micron in width and and spacing obviously there are chips that
are much more advanced than those types of resolution and we have some of the tools that we have brought in house to
be able to do that so traces will be narrower just so that you have to have more of the wires coming up into the
chip um chips also cannot linearly consume more energy as you have more and more
channels so there's a lot of Innovations in the circuit um you know and architecture as as well as a circuit
design topology to make them lower power um you need to also think about if you have all of these spikes how do you send
that off to the end application so you need to think about bandwidth limitation there and potentially Innovations and
Signal processing um physically one of the biggest challenges is going to be um the the the the interface it's always
the interface that breaks um bonding the thin FM array to the um the electronics um it starts to become very very highly
dense uh interconnects so how do you connector Rize that there's a lot of Innovations um in in kind of the 3D
Integrations in the recent years that we can take advantage of um one of the biggest challenges that we do have is
you know forming this hermetic barrier right you know this is an extremely harsh environment that we're in the
brain um so how do you protect it from uh yeah like the brain trying to kill your electronics to also your
electronics leaking things that you don't want into the brain and that forming that hermetic barrier is going
to be a very very big challenge that we uh you know I think are actually well suited to tackle how do you test that
like what's the development environment yeah to simulate that kind of harshness yeah so this is this is where the
accelerated life tester essentially is a brain inovat mhm uh it literally is a vessel that is um made up of and again
again for all intents and purpose for this particular types of test your brain is a saltwater MH and uh and you can uh
also put some other set of chemicals like reactive oxygen species that you know get at kind of these interfaces and
trying to cause a reaction to to uh pull it apart but you could also increase the rate at which these uh interfaces are
aging by just increasing temperature so every 10 degre Celsius that you increase you're basically
accelerating Time by 2X and there's limit as to how how much temperature you want to increase CU at
some point there's some other nonlinear dynamics that that causes you to have other nasty gases to form that just is
not realistic in an environment so what we do is we increase uh in our alt chamber by 20° celius that uh increases
the Aging by four four times so essentially one day in alt chamber is 4 day in calendar year and and we look at
whether the implants still are intact uh including the threats and and operation and all that and operation and all of
that um it obviously is not an exact same environment as a brain because you know brain has mechanical you know other
more uh biological gops that that attack at it um but it is a good test environment testing environment for at
least the the the enclosure and the strength of the enclosure and I mean we've had implants the current version
of the implant that has been in there for I mean close to two and a half years which is equivalent to a decade and they
seem to be fine so it's interesting that the so basically uh close approximation is warm
salt water hot salt water is a good testing environment I yeah by the way I'm drinking element uh which is
basically salt water which is making me kind of it doesn't have computational power the way the brain does but maybe
in terms of in terms of all the characteristics is quite similar and I'm consuming it yeah you have to get it in
the right pH too and then Consciousness will emerge yeah no uh all right by the way the other
thing that also is interesting about our enclosure is uh if if you look at our implant it's not your common looking
medical implant that usually is uh in incase in a titanium can that's laser welded we use this polymer called pctfe
polychoral Tri floro ethylene which is actually commonly used in packs so when you have a pill and you're try to pop
the pill there's that kind of that plastic membrane that's what this is um no one's actually ever used this uh
except us and the reason we um wanted to do this is because it's electromagnetically transparent so when
we talked about the uh electromagnetic inductive charging um with titanium can usually if you want to do something like
that um you know you have to have a sapphire window and it's a it's a very very tough process to scale so you're
doing a lot of iteration here and every aspect of this the materials the software the hard all the whole whole
Shang uh so okay so you mentioned scaling is it possible to have multiple neuralink devices as one of the ways of
scaling to have multiple neuralink devices implanted that's the goal that's the goal yeah we we've had we've had um
I mean our monkeys have had two neural links one in each hemisphere and then we're also looking at you know potential
of having one in moral cortex one in visual cortex and one in whever other cortex so focusing on the particular
function one yink device I mean I wonder if there's some level of customization that could be done on the compute side
so for the motor cortex absolutely that that's the goal and and you know we talk about at neuralink building a
generalized neural interface to the brain um and and that that also is strategically how we're approaching this
um with with marketing and also you know with with regulatory which is hey look um we have the robot and the robot can
access any part of the cortex right now we're focused on motor cortex uh with current version of the N1 that's
specialized for motor decoding tasks but also at the end of the day there's kind of a general compute available there
um uh but you know typically if you want to really get down to kind of hyper optimizing for power and if efficiency
you do want need to get to some specialized function right um but you know what we're saying is that hey you
know you you are now used to this robotic insertion techniques which which you know took many many years of you
know showing data um and and conversation with the FDA um and also internally convincing oursel that this
is this is safe and um now the difference is that if we go to other parts of the brain like
visual cortex which we're interested in as our second product um obviously it's a completely different
environment the cortex is laid out very very differently um you know it's going to be more stimulation Focus rather than
recording um just just kind of creating visual percepts but in the end we're using the same thin film array
technology we're using the same robot insertion technology we're using the same you know packaging technology now
it's more the conversation focused around what are the differences and what are the implication of those differences
in safety and efficacy way that second product is is both hilarious and awesome to me uh that product
being restoring sight for blind people so can you speak to stimulating the visual cortex I mean the the
possibilities there are just incredible to be able to give that gift back to people who don't have sight or even any
aspect of that can you just speak to the challenges of there's several challenges here one of which is like you said from
recording to stimulation just uh any aspect of that that you're both excited and uh uh see
the challenges of yeah I guess I'll start by saying that we actually have been
um capable of stimulating through our denl marray as well as our electronics for years um you know we we have
actually demonstrated some of that capability abilities for uh reanimating the limb in the spinal cord um it it you
know obviously for for the current EFS study you know we've Hardware disabled that so that's that's something that you
know we wanted to Embark as a separate separate Journey um and and you know obviously there are many many different
ways to write information into the brain the way in which we're doing that is through electrical you know passing
electrical current and and kind of causing that to really change the local environment so that you
can sort of artificially cause kind of the the neurons to depolarize in in in nearby
areas for for vision specifically um you know the way our visual system works it it's both well understood I mean
anything with kind of brain there aspects of it that's well understood but in the end like we don't really know
anything um but the way visual system works is that you have Photon hitting your eye and in your eyes uh you know
there are these um specialized cells called photo receptor cells that convert the photon energy into electrical
signals and then they get that then gets projected to um your back of your head your visual cortex um you know goes
through actually um you know theic system called lgn that then projects it out and then in the visual cortex
there's you know visual area one or V1 and then there's bunch of other higher level processing layers like like V2 V3
and there there are actually kind of interesting parallels and when you study the behaviors of these convolutional
neural networks like what the different layers of the network is detecting you know first they're detecting like these
edges and they're then detecting some more natural curves and then they start to detect like objects right kind of
similar thing happens in the brain um and a lot of that has been inspired and also you it's been kind of exciting to
see some of the correlations there um but you know things like from there where does cognition R arise and where
where's color encoded there's there's just not a lot of um understanding fundamental understanding there so in
terms of kind of bringing sight back to those that are blind um there are many different forms of blindness uh there's
actually million people one million people in the US that are legally blind um you know that means like certain uh
like score below in kind of the the visual test um I think it's something like if you can see something uh at 20
ft distance that normal people can see at 200 ft distance like you're like if you're worse than that you're legally
blind so fundament that means you can't function effectively corre using sight in the world yeah like to navigate your
environment um and yeah there are different forms of blindness there are forms of blindness where uh there's some
degeneration of your uh retina um these photo receptor cells and and rest of your visual uh you know
processing that I described is intact and for those types of individuals uh you may not need to maybe stick
electrodes into the visual cortex you can actually um uh build retinal prosthetic devices that actually just
replaces a function of that retinal cells that are degenerated and there are many companies that are working on that
but that that's a very small slice Alia significance still smaller slice of folks that are legally blind um you know
if there's any damage along that circuitry whether it's in the optic nerve or you know uh just the lgn
circuitry or any any break in that circuit that's not going to work for you um and uh the source of where you need
to actually cause that visual percept to happen because your biological mechanism is not doing that is by placing
electrodes in the visual cortex in the back of your head and the way in which this would work is
that you would have an external camera whether it's um you know something as unsophisticated as a GoPro or you know
some sort of wearable you know Rayban type glasses that meta is working on that captures a scene right um and that
scene is then converted to a set of electrical impulses or stimulation pulses that you would uh activate in
your visual cortex through um these infil aray and by playing some C you know concerted
kind of uh Orchestra of these stimulation patterns you can create what's called phosphines which are these
um kind of white yellowish dots that you can also create by just pressing your eyes um you can actually create those
percepts by stimulating the visual cortex and the name of the game is really have many of those and have those
percepts be the phosphines be as small as possible so that you can start to tell apart like the individual pixels of
the the of the screen right so if you have many many of those you know potentially you'll be able to um you
know in in the long term be able to actually get naturalistic Vision but in the mid like short term to maybe midterm
um being able to at least be able to have object detection algorithms run on your um on your glasses uh the pre
processing units and then being able to at least see the edges of things so you don't bump into stuff it's incred
inredible this is really incredible so you basically would be adding pixels and your brain would start to figure out
what those pixels mean yeah and like with with different kinds of assistant on the signal processing on all fronts
yeah the the thing that actually so a couple things one is um you know obviously if you're uh blind from birth
um the way brain works especially in the early age um neuroplasticity is really nothing
other than you know kind of your brain and different parts of your brain fighting for The Limited territory yeah
um and and I mean very very quickly you see you see cases where you know people that are I mean you also hear about
people who are blind that have heightened sense of hearing or some other senses and the reason for that is
because that cortex that's not used just gets taken over by these different parts of the cortex so for those types of
individuals um I mean I guess they're going to have to Now map some other parts of their senses into what they
call Vision but it's going to be obviously a very very different conscious experience um
before so so I think that's a interesting caveat the other thing that also is important to highlight is that
we're currently limited by our biology in terms of the the wavelength that we can see there's a very very small
wavelength that is a visible um light wavelength that we can see with our eyes but when you have an external camera
with this um BCI system you're not limited to that you can have infrared you can have UV you can have whatever
other spectrum that you want to see and whether that gets math to some sort of weird conscious experience I have no
idea but when I you know often time I talk to people about the goal of neuralink being going beyond the limits
of our biology um that's sort of what I mean and if you're able to control the kind of raw signal is that when we use
our site we're getting the photons and there's not much processing on it if you're be able to control that
signal maybe you can do some kind of processing maybe you do object detection ahead of time yeah you're doing some
kind of pre-processing and there's a lot of possibilities to explore that so it's not just in increasing sort of thermal
imaging that kind of stuff but it's also just doing some kind of interesting processing yeah I I mean my my theory of
how like visual system works also is that um I mean there's just so many things
happening in the world and there's a lot of photons that are going into your eye and it it's unclear exactly where some
of the pre-processing steps are happening but I I mean I actually think that just just from a fundamental
perspective there's just so much uh the reality that we're in if it's a reality um is so there's so much data and I
think humans are just unable to actually like eat enough actually to process all that information so there's some sort of
filtering that does happen whether that happens in the retina whether that happens in different layers of the
visual cortex unclear but like the analogy that I sometimes think about is you know if uh if your brain is a CCD
camera and the in all of the information in the world is a sun um and when you try to actually look at the sun with the
CCD camera it's just going to saturate the sensors right cuz it's a enormous amount of energy so you what you do is
you end up adding these uh filters right to just kind of narrow the information that's coming to you and being captured
and I think you know things like our experiences or our
um uh you know like drugs like profal that like anesthetic drug or you know psychedelics what they're doing is
they're kind of swapping out these filters and putting in new ones or removing older ones and
kind of controlling our conscious experience yeah man not to distract from the topic but I just took a very high
dose of iasa in the Amazon jungle so yes it's a nice way to think about it you're swapping out different different
experiences and with neur link being able to control that primarily at first to improve function not for
entertainment purposes or enjoyment purposes but yeah giving back lost functions Lo giving back lost functions
and there especially when the function is completely lost anything is a huge help would you uh
implant a neuralink device in your own brain absolutely I mean maybe not right now but absolutely what kind of
capability once reached you start getting real Curious and almost get a little antsy like like jealous of people
that get as you watch them get implanted yeah I mean I think I mean even even with our early participants if
they start to do things that I I can't do uh which I think is in the realm of possibility for them to be able to get
you know 15 20 if not like 100 BPS right um there's nothing that fundamentally stops us from being able to achieve that
type of performance um I mean I would certainly get jealous
um that they can do that I I should say that watching no and I get a little jealous because he say so much fun and
it seems like such a chill way to play video games yeah so I mean the thing that also is hard to appreciate
sometimes is that you know he's doing these things while mult like while talking and I mean it's multitasking
right so it's it's clearly it's obviously cognitive cognitively uh intensive but similar to how you know
when we talk we move our hands like these things like you know like are multitasking I mean he's able to do that
and you know you won't be a to do that with other assisted technology as far as I I'm aware you know if you're obviously
using like an ey tracking device you know you're very much fixated on that thing that you're trying to do and if
you're using voice control I mean like if you say some other stuff yeah you don't get to use that yeah the the
multitasking aspect of that is really interesting so it's not just the BPS for the primary task it's the it's
the parallelization of multiple task if you if you take if you measure the BPS for the entirety of the human organ ISM
so if you're talking and doing a thing with your mind and looking around mhm also I mean there's just a lot of
paralyzation that that can be happening but I mean I think at some point for him like if he wants to really achieve those
high level BPS it does require like you know full attention right um and that's a separate circuitry that that um is a
big mystery like how attention works and you know yeah attention like cognitive load I've done I've I've read a lot of
literature on people doing two tasks mhm like uh you have your primary task and a secondary task and the secondary task is
is a source of distraction and how does that affect the performance on the primary task and there's depending on
the task there's a lot of interesting I mean this is an interesting computational device right and I think
there's to say the least a lot of Novel insights that can be gained from everything I mean I personally am
surprised that no one's able to do such incredible control of the cursor while talking and also being nervous at the
same time because he's talking like all of us Sor if you're talking in front of the camera you get nervous so all of
those are coming into play he's able to still achieve high performance surprising I mean all of
this is really amazing uh and I think at just after researching this really in depth I kind of wanted your
link get in the line and also the safy get in mind well we should say the registry is for people who have
quadriplegia and all that kind of stuff so there'll be a separate line for people um they're just
curious uh like myself so now that noan patient P1 is part of the ongoing Prime study um what's the high level vision
for P2 P3 P4 P5 and just uh the expansion into other human beings that are getting to experience this
implant yeah I mean the prim goal is uh you know for for our study in the first place is to achieve safety end points
just understand um safety of this device as well as the implantation process um and also at the same time understand the
efficacy and the impact that it could have on uh the potential user's lives um and just because you have and you know
you're living with tetr Leia it doesn't mean your situation same as another person living with tetelia it's widely
widely varying um and and you know you're it's something that you know we're hoping to also understand how our
technology can serve not just a very small slice of those individuals but you know broader group of individuals and
being able to get the feedback to you know just really build the just the best product for them um so are
are you know there's there's obviously also uh you know go goals that we have and and the primary purpose of the early
feasibility study is to learn from each and every participant to improve the device improve the surgery before you
know we embark on what's called a pivotal study that then is a much larger um uh trial that starts to look at
statistical significance of your endpoints um and that's required before you can then Market the device um uh and
and you know that's how it works in the US and just generally around the world that's that's the process you follow so
you know our goal is to really just understand from people like Nolan P2 P3 future participants what aspects of our
device needs to improve you know if if it turns out that people are like I really don't like the fact that it lasts
only 6 hours I want to be able to use this computer for you know like 24 hours I mean that's that is a you know user
needs and user requirements uh which we can only find out from just just being able to engage with them so before the
pivotal study there's kind of like a rapid Innovation based on individual experiences you're learning from
Individual people how they use it like the like the high resolution details in terms of like cursor control and signal
and all that kind of stuff to like life experience yeah so there's Hardware changes but also just just firmware
updates um so even even when we um you know had had that sort of uh recovery event for Nolan uh you know he now has
the new firmware that that that he um has been uh updated with and you know it's similar to how like your phones get
updated all the time with new firmwares for security patches whatever new functionality UI right um and that's
something that is possible with our implant it's not a static one-time device that that can only do the thing
that it said it can do I mean similar to Tesla you can do over the a firmware updates and now you have completely new
user user interface and um all this bells and whistles and improvements on you know everything like the latest
right uh that's that's that's um you know when we say generalized platform that's what we're talking about yeah
it's really cool how the the app that Nolan is using there's like calibration all that all that kind of
stuff and then there's update just you just click and get an update uh what other future capabilities
are are you kind of looking to you said Vision that's a fascinating one uh what about sort of accelerated typing or
speech this kind of stuff what and what else is there what's yeah those those are still in the realm realm of um
movement program so so largely speaking we have two programs we have the movement program and we have the the
vision program uh the movement program you know currently is focused around you know the digital Freedom as you can
easily guess if you can control you know 2D cursor in the digital space you could move anything in the physical space um
so robotic arms wheelchair your environment uh or even really like whether it's through the phone or just
like directly to those interfaces so like to those machines um so we're looking at ways to kind of expand those
types of capability even for Nolan um that requires you know conversation with the FDA and kind of showing safety data
for you know if there's a robotic arm or wheelchair that you know we can guarantee that they're not going to hurt
themselves accidentally right um it's very different if you're moving stuff in the in the digital domain versus like in
the physical space you can actually um potentially harm to the participants um so we're working through that right now
um speech does involve different areas of the brain speech prosthetic is very very fascinating and there's actually
been a lot of really um amazing work that's been happening in Academia um you know Sergey staviski at UC Davis Jamie
Henderson and you know late Krishna shoi um at Stanford doing just some incredible amount of work in improving
speech uh neuroprosthetics and it those are actually looking more at
parts of the motor cortex that are controlling you know these focal articulators and you know being able to
like even by mouthing the word or imagine speech you can pick up those signals um the more sophisticated higher
level processing areas like you know the broker's area or you know War's area those are still very very big mystery in
terms of the the underlying mechanism of how all that stuff works but um yeah I mean I think I think neural
Ling's evental goal is to kind of understand those those things um and and be able to provide a platform and tools
to be able to understand that and study that this is where I get to the pothead questions um do you think we can start
getting insight into things like thought so speech is uh there's a muscular component like you said there's
like the act of producing sounds but then what about the internal things like cognition like lowlevel thoughts and
high level thoughts do you think we'll start noticing kind of signals that could be picked up they could
um they could be understood they could be maybe used in order to interact with the outside
world in some ways like I guess this starts to kind of get into the hard problem of Consciousness um and
uh I mean on on one hand all of these are at some point set of electrical
signals that um from there maybe it it in itself is giving
you the cognition or the meaning or somehow human mind is incredibly amazing storytelling machine so we're telling
ourselves and fooling ourselves that there's some interesting meaning here um but
I I I I certainly think that BCI and you know really BCI at the end of the day is a set of tools that help you kind of
study the underlying mechanisms in in a both like local but also broader sense um and whether you know there's some
interesting patterns of like electrical signal that means like you're thinking this versus and you can either like
learn from like many many sets of data to correlate some of that and be able to do mind reading or not I'm not I'm not
sure um I certainly would not kind of blow that out as a possibility but um I I I think BCI alone probably can't do
that there's probably additional set of tools and framework and you also like just hard problem of Consciousness at
the end of the day is rooted in this philosophical question of like what is the what's the meaning of it all what's
the nature of our existence like where is the Mind emerg from this complex Network
like yeah how does the uh how does do the subjective experience emerge from just a bunch of spikes electrical spikes
yeah yeah I mean we we do really think about BCI and what we're building as a tool for
understanding the mind the brain the only question that matters there's actually um there
actually is um some biological existence proof of like what it would take to kind of start to form
some of these experiences that maybe unique um if you actually look at every one of our brains there there two
hemispheres there's a left sided brain there's a right sided brain and I mean I unless you have some other conditions
you normally don't feel like left leg or right legs MH like you just feel like one legs right so what is happening
there right um if you actually look at the two hemispheres there's a a structure that kind of connectorized the
two called the Corpus colossum that is supposed to have around 200 to 300 million connections or
axons um so whether that means that's the the number of interface and electrod that we need to create some sort of Mind
meld or from that like whatever new conscious experience that you you can experience um but yeah I do think that
there's like kind of interesting um existence proof that we all
have and that threshold is unknown at this time oh yeah these things everything in this domain is you know
speculation right um and then there will be uh you'd be continuously pleasantly surprised uh do you see a world where
there's millions of people like tens of millions hundreds of millions of people walk
around with the neuralink device in their or multiple neuralink devices in their brain I do first of all there
there are like if you look at worldwide um people suffering from movement disorders and visual defis I mean that
that's uh in the tens if not hundreds of millions of people um so that that alone I think there's a lot of uh benefit and
and potential good that we can do with this type of technology and when she start to get
into kind of neuro like psychiatric application you know depression um anxiety hunger or you know
obesity right like mood control of appetite I mean that starts to become you know very real to everyone
not to mention that every uh most people on earth have a smartphone and once BCI starts compe
eting with a smartphone as a preferred methodology of interacting with the digital world that also becomes an
interesting thing oh yeah I mean that yeah this is even before going to that right I mean there's like almost I mean
the entire world that could benefit from these types of thing and then yeah like if we're talking about kind of next
generation of how we interface with you know machines or even ourselves uh in many ways I think um BCI can can play a
role in that um and you know some of the things that I also talk about is I I I do think that there is a real
possibility that you could see um you know 8 billion people walking around with neural link well thank you so much
for pushing ahead and uh I look forward to that exciting future thanks for having me thanks for listening to this
conversation with DJ saw and now dear friends here's Matthew McDougall the head neurosurgeon at your
link when did you first become fascinated with the human brain since forever uh far back as I can remember
I've been interested in the human brain I mean uh I was you know a thoughtful kid
and a bit of an outsider and you you know sit there thinking about what the most important things in the world
are uh in your in your little tiny adolescent brain and the answer that I came to that
I converged on was uh that all of the things you can possibly conceive of as things that are important for human
beings to care about are literally contained you know in the skull uh both the perception of them and their
relative values and you know the solutions to all our problems and all of our problems are all contained in the
skull and if we knew more about how that worked uh how the brain encodes information and generates desires and
generates Agony and suffering uh we we could do more about it you know you think about all the all
the really great triumphs in human history you think about all the really horrific
tragedies um you know you think about the Holocaust you think about um any prison full of human
stories uh and all of those problems boil down to neurochemistry so if you get a little
bit of control over that you provide people the option to do better in the way I read history the way
people have dealt with having better tools is that they most often in the end do better uh with huge
asterisks but I think it's a an interesting a worthy a noble pursuit to give people more options more tools
yeah that's a fascinating way to look at human history you just imagine all these neurobiological mechanisms Stalin Hitler
all of these jenus Khan all of them just had like a a brain it just a bunch of neurons you know like few tons of
billions of neurons uh gaining a bunch of information over a period of time they
have set a module that does language and memory and all that and from there in in in the case of those people they're able
to murder millions of people yeah and all that coming from uh there's not some glorified
notion of a a dictator of this enormous mind or something like this it's just it's just the brain yeah yeah I mean a
lot of that has to do with how well people like that can organize those around them other brains yeah and so I
always find it interesting to look to primatology you know look to our closest non-human relatives uh for Clues as to
how humans are going to behave and and what particular humans are able to achieve and so you look
at um chimpanzees and bonobos and you know they're similar but different in their social structures
particularly and I went to Emory in Atlanta and studied under uh Fran Dall the great Fran Dall who was kind of the
leading primatologist uh who recently died and his work in at looking at chimps
through the lens of you know how you would watch an episode of Friends and understand the motivations of the
characters interacting with each other he would look at a chimp colony and basically apply that lens I'm massively
oversimplifying it if you do that instead of just saying you know subject 473 you know through his feces at
subject 471 you talk about them in terms of their human struggles Accord them the
Dignity of themselves as actors with understandable goals and drives what
they want out of life and primarily it's you know the things we want out of life food sex
companionship um Power uh you can understand chimp and Boba behavior in those same lights uh
much more easily and I think doing so gives you the tools you need to reduce human behavior from the kind of false
complexity that we layer on to it with language and look at it in terms of oh well these humans are looking for
companionship sex food power um and I think that that's a pretty powerful tool to have in
understanding human behavior and I just uh went to the Amazon jungle for a few weeks and you it's a very visceral
reminder that a lot of life on Earth is just trying to get laid yeah they're all screaming at each other like I saw a lot
of monkeys and they're just trying to impress each other or maybe there's a battle for power but a lot of the battle
for power has to do with them getting laid right reading rights often go with Alpha status and so if you can get a
piece of that then you're going to do okay and would like to think that we're somehow fundamentally different but
especially when it talk comes to primates where really AR you know we can use fancer poetic language but uh maybe
some of the underlying drives that motivate us are um similar yeah I think that's true and all that is coming from
this the brain yeah uh so when did you first start studying the the brain as like as a biological mechanism basically
the moment I got to college I started looking around for labs that I could uh do Neuroscience work in uh I originally
approached that from the angle of uh looking at interactions between the brain and the immune system which isn't
the most obvious place to start but um I had this idea at the time that the contents of your thoughts would
have an impact a direct impact maybe a powerful one on uh non-conscious systems in your body the
systems we think of as you know homeostatic autom IC mechanisms like fighting off a virus like repairing a
wound um and sure enough there are big crossovers between the two I mean it gets to um kind of a key point that I
think goes underrecognized one of the things people don't recognize or or appreciate about the human brain uh
enough and that is that it basically controls or has a huge role in almost everything that your body does um like
you try to try to name an example of something in your body that isn't directly controlled or massively
influenced by the brain and uh it's pretty hard I mean you might say like bone healing or something but uh even
those systems the hypothalamus and pituitary end up playing a role in coordinating the endocrine system that
does have a direct influence on say the calcium level in your blood that goes to Bone healing so non-obvious connections
between those things uh implicate the brain as really a potent prime mover in all of Health one of the things I
realized in the other direction too how most of the systems in the body integrated with the human brain like
they affect the brain also like the immune system um I think there's just you know people who study
Alzheimer's and uh those kinds of things is it's just surprising how much you can understand
of that from the immune system from the other systems that don't obviously seem to have to anything to do with sort of
the nervous system they all play together yeah you could understand how that would be driven by Evolution too
just in some simple examples if you get sick if you get a communicable disease you get the
flu uh it's pretty advantageous for your immune system to tell your brain hey now
be antisocial for you know a few days don't go be the life of the party tonight in fact maybe just cuddle up
somewhere warm under a blanket and just stay there for a day or two and sure enough that tends to be the behavior
that you see both in animals and and in humans if you get sick elevated levels of inter lucans in your blood and tnf
Alpha in your blood ask the brain to cut back on social activity
uh even moving around you have lower look motor activity uh in animals that are infected with
viruses so from there the early days in Neuroscience to surgery when did that step happen was a
leap you know it was sort of an evolution of thought I wanted to study the brain so I started studying the
brain uh in undergrad in this neuroimmunology lab uh I from there uh realized at some
point that I didn't want to just generate knowledge I wanted to affect real changes in the actual World in
actual people's lives and so after having not really thought about going into medical school I was on a track to
go into a PhD program I said well I'd like I'd like that option I'd like to actually potentially
help tangible people in front of me and uh doing a little digging found that there exists these MD PHD programs where
you can choose not to choose between them and do both and so uh I went to USC for medical school and
had a joint PhD program with Caltech um where I met actually chose that program particularly because of
a researcher at Caltech named Richard Anderson who's one of the Godfathers of primate
Neuroscience has a a maak lab where Utah rays and other electrodes were being inserted into the brains of monkeys uh
to try to understand how intentions were being encoded in the brain so you know I ended up there with the idea that maybe
I would be a neurologist and study the brain on the side uh and then discovered that neurology um again I'm gonna make
enemies by saying this but neurology uh predominantly and and distressingly to me is is the practice
of diagnosing a thing and then saying good luck with that there's not much we can
do um and neurosurgery very differently uh is a it's a powerful lever on taking people that are headed in a bad
Direction and changing their course uh in the sense of brain tumors that are potentially treatable or curable with
surgery um you know even aneurysms in the brain blood vessels that are going to rupture you can uh save lives really
is at the end of the day what What mattered to me and so uh I was at USC as I mentioned that
happens to be one of the great neurosurgery programs and so I met these truly epic uh neurosurgeons Al kesi and
and M A puzzo and Steve ginata and Marty Weiss these these sort of Epic people that were just human beings in front of
me and so it kind of changed my thinking from neurosurgeons are distant gods that live on another planet and occasionally
come and visit us to these are humans that have problems and are people and uh there's nothing fundamentally preventing
me from being one of them uh and so um at the last minute in medical school I changed gears from going into a
different specialty and and switched into neurosurgery uh which cost me a year I
had to do another year of research uh because I was so far along in the process uh that um to switch into
neurosurgery the deadlines had already passed so was a a decision that cost time but
absolutely worth it what was the hardest part of the training on the on the neurosurgeon
track yeah two things I think that you know residency in neurosurgery is sort of a
competition of pain of like how much pain can you eat and smile yeah uh and so
there's workout restrictions that uh are not really they're viewed at I think
internally among the residents as weakness and so most neurosurgery residents try to work as hard as they
can and that I think NE necessarily means working long hours and sometimes over the work hour limits and you know
we care about being compliant with whatever regulations are uh in front of us but I think more important than that
people want to give all give their all in becoming a better neurosurgeon because the the stakes are so high and
so it's a real fight to get residents uh to say go home at the end of their shift and not stay and do more
surgery Are you seriously saying like one of the hardest things is literally like getting forcing them to get sleep
and rest and all this kind of stuff historically that was the case I think I think the Next Generation I think the
next generation is more uh compliant and more self is what you mean all right I'm just I'm just kidding I'm just kidding I
didn't say it now I'm making enemies no okay I get it wow that's fascinating uh so what was the second thing the
personalities and maybe the two are connected but so is was it pretty competitive
it's competitive and it's also um you know as we touched on earlier primates like power and I think um
neurosurgery has long had this Aura of um mystique and excellence and whatever about it and so it's it's an
invitation I think for people that are cloaked in that Authority you know board certified neurosurgeon is basically a
walking uh fallacious appeal to Authority right you have licensed to walk into any room and act like you're
you know an expert on whatever and fighting that tendency is not something that most neurosurgeons do well humility
isn't the Forte yeah one of the so um I have friends uh who know you and whenever they speak about you that
your you're have the surprising quality for a neurosurgeon of humility which I think IND DEC cases
that it's not it's not as common is perhaps in other professions because there is a kind of
gigantic sort of heroic aspect to neurosurgery and I think it gets to people's head a little bit Yeah well
that I think that uh you know that allows me to play well at an Elon company yes because Elon uh one of his
strengths I think is to just instantly see through fallacy from Authority so nobody walks into a room that he's in
and says well God damn it you have to trust me I'm the guy that built the last you know 10 Rockets or something and he
says well you did it wrong and we can do it better or I'm the guy that you know kept Ford alive for the last 50 years
you listen to me on how to build cars and he says no and so you don't walk into a room
that he's in and say well I'm a neurosurgeon let me tell you how to do it uh he's going to say well I'm a human
being that has a brain I can think from principles myself thank you very much uh and here's how I think it ought to be
done let's go try it and see who's right uh and that's a you know proven I think over and over in his case to be a very
powerful approach if we just take that tangent there's a fascinating interdisciplinary team at neur link that
you get to interact with um including Elon what do you think is the secret to a successful team or what have you
learned from just getting to observe these folks yeah World experts in different disciplines work
together yeah there there's a sweet spot uh where people disagree and forcefully speak
their mind and passionately defend their position and yet are still able to accept information from others and
change their ideas when they're wrong and so I like the analogy of sort of how you polish rocks you put hard things
in a in a hard container and spin it people bash against each other and out comes uh you know a more refined product
and so uh to make a good team at nurlink we've tried to find you know people that
are not afraid to defend their ideas passionately and you know occasionally strongly
disagree with people uh that they're that they're working with and have the best idea come out on
top um it's not an easy balance again to refer back to the primate brain it's not something that is inherently built into
the the primate brain to say I passionately put all my chips on this position and now I'm just going to
walk away from it and admit you are right you know part of our brains tell us that that is a power loss that is a
loss of face a loss of standing in the community and uh and and now you're a a Zeta
chump because your idea got trounced um and you just have to you know recognize that that little voice in
the back of your head is maladaptive and it's not helping the team win yeah you have to have the confidence to be able
to walk away from an idea that you hold on to yeah yeah and if you do that often enough you're actually going
to uh become the best of in the world that your thing I mean that kind of that rapid iteration yeah you'll at least be
a member of a winning team ride the wave uh what what did you learn you
mentioned there's a lot of amazing uh neurosurgeons at USC what what lessons about surgery in life have you learned
from those folks yeah I think working your ass off working hard while um you know functioning as a member of a team
getting a job done that is incredibly difficult um you know working incredibly long hours being up all night taking
care of someone that you know you think probably won't survive no matter what you do working hard to make people that
you passionately dislike look good the next morning these folks were Relentless in
their pursuit of um excellent Neurosurgical technique decade over decade and and I think we're
well recognized for that that Excellence so you know especially Marty Weiss Steve ganada uh mik apuzzo they made huge
contributions not only to surgical technique but they built training programs that
trained dozens or hundreds of amazing neurosurgeons I was just lucky to kind of be in their wake what's that like you
mentioned mentioned doing a surgery where the person is likely not to survive does
that wear on you yeah um you know it's especially
challenging um when you with all respect to to our elders uh it doesn't hit so much when you're
taking care of an 80-year-old and something was going to get them
pretty soon anyway and so you lose a patient like that and it it was part of the natural course of what is expected
of them in the in the coming years regardless uh taking care of you know a father of two or three
four young kids someone in their 30s that didn't have it coming and they show up in your ER
having their first seizure of their life and L and bold they've got a a huge malignant inoperable or incurable brain
tumor you can only do that I think a handful of times um before it really starts eating
away at your at your armor um or you know a young mother that shows up that has a giant Hemorrhage in
her brain that she's not going to survive from and you know they bring her
four-year-old daughter in to to say goodbye one last time before they turn the ventilator off
that um you know the great Henry Marsh is an English neurosurgeon who said it best I
think he says every neurosurgeon carries with them a private graveyard and I I definitely feel that
um especially with young parents uh that that kills me uh they they had a lot more to
give the the loss of those people specifically has a you know knock on effect that's going to make the world
worse for people uh for a long time and it's just hard to feel powerless in the face of
that you know and that's where I think you have to be uh borderline evil to fight against a company like neuralink
or to constantly be taking pot shots at us because what we're doing is to try to
fix that stuff we're trying to give people options uh to reduce suffering uh we're
trying to we're trying to take the the pain out of life that uh broken brains brings in and and
um yeah this is just our our little way that we're fighting back against entropy I
guess yeah this the the amount of suffering that's endured when some of the things that we take for granted that
our brain is able to do is taken away uh is immense and to be able to restore some of that functionality is a real
gift yeah we're just starting we're we're going to we're going to do so much more um well can you take me through the
full procedure of implanting say the N1 sure chip in New Link yeah it's a really simple really simple straightforward
procedure uh the the human part of the surgery uh that that I do is dead simple it's one of the most
basic neurosurgery procedures imaginable and I think there's evidence that it some version of
it has been done for thousands of years uh there are examples I think from ancient Egypt of healed or partially
healed uh tations and from uh Peru or you know ancient times in South America uh where uh these Proto surgeons would
drill holes in people's skulls you know presumably to let out the evil spirits but maybe to drain blood clots and
there's evidence of bone healing around the edge meaning the people at least survive some months uh after a procedure
and so what we're doing is that we are making a cut in the skin on the top of the head over the area of the brain that
is the most potent uh representation of hand intentions and so if you if you are an expert concert pianist you know
this part of your brain is lighting up the entire time you're playing we call it the hand knob the hand knob so it's
all the like the finger movements all this all yeah all of that is just firing away yep there's a little squiggle in
the cortex right there one of the folds in the brain is kind of doubly folded right on that spot and so you can look
at it on an MRI and say that's the hand knob and then you you do a functional test in a special kind of MRI called an
a functional MRI fmri and this part of the brain lights up when people even quadriplegic people
whose brains aren't connected to their finger movements anymore they imagine finger movements and this part of the
brain still lights up so we can ID that part of the brain in anyone who's preparing to enter our trial and say
okay that that part of the brain we confirm is your hand intention area um and so uh I'll make a little cut
in the skin we'll flap the skin open just like kind of opening the hood of a car only a lot
smaller make a perfectly round uh 1 in diameter hole in the skull remove remove that bit of
skull uh open the lining of the brain the covering of the brain it's like a like a little bag of water that the
brain floats in and then show that part of the brain to our robot and then the this is where the
robot shines it can come in and take these tiny you know much smaller than human hair electrodes and precisely
insert them into the cortex into the surface of the brain to a very precise depth in a very
precise spot that avoids all the blood vessels that are coating the surface of the brain and after the robot's done
with its part then you know the human comes back in and puts the implant into that hole in the skull and covers it up
uh screwing it down to the skull and sewing the skin back together um so the whole thing is you
know a few hours long it's extremely low risk compared to the average neurosurgery involving the brain that
that might say open up a deep part of the brain or manipulate blood vessels in the brain uh this this opening on the
surface of the brain with um with only cortical micro insertions carries um significantly less
risk than a lot of the you know tumor or aneurysm surgeries that are routinely done so cortical micro insertions that
are via robot and and computer vision are designed to avoid the blood vessels exactly so uh I know you're a bit biased
here but let's compare human and machine sure so what are human surgeons able to do well and what are robot surgeons able
to do well at this stage of our human civilization development yeah yeah
that's a good question um humans uh are general purpose machines were able to adapt to unusual situations
we're able to change the plan on the Fly um I remember well a surgery that I was
doing many years ago down in San Diego where the plan was to um open a small hole behind the ear
and go reposition a blood vessel that had come to lay on the facial nerve the trigeminal nerve uh the nerve that goes
to the face when that blood vessel lays on the nerve it can cause just intolerable horrific shooting pain that
people describe like being zapped with a cattle prod and so the beautiful elegant surgery is to go move this blood vessel
off the off the nerve the surgery team we we went in there and started moving this blood vessel and then found that
there was a giant aneurysm on that blood vessel that was not easily visible on the preop scans and so the plant had to
dynamically change and that the um human surgeons had no problem with that were trained for all those things robots
wouldn't do so well in that situation at least in their current Incarnation uh fully robotic surgery
like you know the the electrode insertion portion of of the nerling surgery it goes according to a set plan
and so the humans can interrupt the flow and change the plan but the robot can't really change the plan Midway through it
operates according to how it was programmed and how it was asked to run it does its job very precisely uh but
not with a wide degree of latitude and how to react to changing conditions so there could be just a very large number
of ways that you could be surprised as a surgeon when you enter a situation there could be subtle things that you have to
dynamically adjust to correct and robots are not good at that currently currently I
think uh we are at the dawn of a new era with AI of the parameters for robot responsiveness to be dramatically
broadened right I mean you can't look at a self-driving car and say that it's operating under very narrow
parameters you know if a chicken runs across the road it wasn't necessarily programmed to deal with that
specifically but a whmo or self-driving Tesla would have no problem reacting to that
appropriately uh and so surgical robots aren't there yet but give it time and then there could be a
lot of sort of inter like semi-autonomous possibilities of maybe a robotic surgeon could say this situation
is perfectly familiar or the situation is not familiar and in the not familiar case a human could take over but
basically like be very conservative okay this for sure has no issues no surprises and then let the humans deal
with the Surprises with the edge cases all that yeah uh that's one possibility so like you think
eventually uh you'll be out of the job what you being neurosurgeon your job being neurosurgeon humans there will not
be many neurosurgeons left on this Earth I'm not worried about my job in my in the course of my professional
life I think I I would tell my my kids not necessarily to go in this line of work uh depending
on depending on how things look in 20 years it's so fascinating because I I mean I if I have a line of work I would
say it's programming and if you ask me like for the last I don't know 20 years what I would recommend for people I
would I would tell them yeah go there's this you will always have a job if you're a programmer because there's more
and more computers and all this kind of stuff and uh it pays well but then you you realize these large
language models come along and they're really damn good at generating code yeah so it's over night you could be
surprised like wow wa what is the contribution of the human really but then you start to think okay it does
seem that humans have ability like you said to deal with novel situations in the case of programming it's the ability
to kind of come up with novel ideas to solve problems it's it seems like like machines aren't quite yet able to do
that and when the stakes are very high when it's life critical as it is in surgery especially neurosurgery then it
starts the the stakes are very high for a robot to actually replace a human but it's fascinating that in this case of
neuralink there's a uh human robot collaboration yeah yeah it's I do the parts I can't do and it does the parts I
can't do um and we we are friends uh I I saw that there's a lot of practice going on so I mean everything
in New link is is tested extremely rigorously but one of the things I saw that there's a proxy on which the
surgeries are performed yeah so this is both for the robot and for the human for everybody involved in the entire
pipeline yep what's that like practicing the surgery it's pretty intense uh so there's no analog to this in human
surgery uh human surgery is sort of this artisanal craft that's handed down directly from Master to pupil over the
generations yes I mean literally the way you learn to be a surgeon on humans is by doing surgery on humans I mean first
you watch uh your professors do a bunch of surgery and then finally they put you
know the trivial parts of the surgery into your hands and then the more comp Le Lex parts and as your understanding
of the the point and the purposes of the surgery increases you get more responsibility in the perfect condition
doesn't always go well in neural Link's case the approach is a bit different um we of course practiced as far as we
could on animals we did hundreds of animal surgeries um and when it came time to do
the first human uh we had a just a amazing team of engineers build incredibly lifelike models one of
the engineers Fran Romano in particular built built a pulsating brain in a custom 3D printed skull that matches
exactly the the patients Anatomy including their face and uh scalp characteristics and
so when I was able to practice that I mean it's as close as it really reasonably should get
uh to to being the real thing in all the details including you know the having a a Manakin body attached to this custom
head and so when we were doing the practice surgeries we'd wheel that body into the CT scanner and take a mock CT
scan and wheel it back in and conduct all the normal safety checks verbally you know stop this patient we're
confirming his identification is mannequin number blah blah blah and then opening the brain in exactly the right
spot using standard operative neuronavigation equipment standard surgical drills in in the same o that we
do all of our practice surgeries in at nurlink and having the skull open and have the brain pulse which adds a degree
of difficulty for the robot to you know perfectly precisely plan and insert those electrodes to the right depth and
location and so uh yeah we we uh kind of broke new
ground on how extensively we practiced for this surgery so there was a historic moment a big milestone uh for
nink in part for Humanity with uh the first human getting a neuralink implant in January of this year uh take me
through the surgery uh on Noland what did he feel like to be part of this yeah well we um
we're lucky to have just incredible Partners at the baron neurologic Institute they
are uh I think the premier Neurosurgical Hospital in the world uh
they they made everything as easy as possible for the trial uh to get going and and helped us immensely uh with
their expertise on how to uh how to arrange the details it was a much more high pressure surgery in some ways I
mean even though the you know the outcome wasn't particularly in question in terms of our
participants safety the number of observers you know the number of people there's conference
rooms full of people watching live streams in the hospital um rooting for this to go
perfectly and that just adds pressure that is not typical for uh even the most intense production
neurosurgery say removing a tumor or you know placing deep brain stimulation electrodes and it had never been done on
a human before there were unknown unknowns um and so uh definitely a a moderate pucker
Factor there for the whole team uh not knowing if we were going to encounter say a degree of brain movement that was
unanticipated or uh a degree of brain sag that took the brain far away from the skull and made it difficult to
insert or some other unknown unknown problem fortunately everything uh went well and that that surgery was one of
the smoothest uh outcomes we could have imagined were you nervous I mean you're
bit of quarterback and like in the Super Bowl kind of situation extremely nervous uh extremely I was very pleased when it
went well and then and when it was over um looking forward to number two yeah even with all that practice all of that
just you've never been in a situation that's so high stakes in terms of people watching yeah and we should also
probably mention given how the media works a lot of people um you know maybe in a dark kind
of way hoping it doesn't go well well I think wealth is easy to hate um or Envy or or whatever and uh I think there's a
whole industry around driving clicks and bad news is great for clicks and so any way to take an event and turn
it into bad news uh is going to be really good for for clicks it just sucks because I think in it puts pressure on
people it discourages people from from trying to solve really hard problems because to solve hard problems
you have to go into the unknown you have to do things that haven't been done before and you have to take risks yeah
uh calculated risks you have to do all kind of safety precautions but risks nevertheless and uh I just wish there
would be more celebration of that of the risk taking versus like yeah people just waiting on the on on the sidelines like
waiting for failure yeah and then pointing out the failure uh yeah it sucks but you know in this case it's
it's it's really great that everything went just flawlessly but it's unnecessary pressure I would say now
that there is a human with literal skin in the game you know there's a participant who whose well-being rides
on this doing well you have to be a pretty bad person to be rooting for that to go wrong yeah um and so you know
hopefully people look in the mirror and and realize that at some point so did you get to actually front
row seat like watch the robot work like what uh you get to see the whole thing yeah I mean I you know because an MD
needs to be charge of all of the medical decision- making throughout the process um I unscrubbed from the
surgery after exposing the brain and presenting it to the robot and um place the targets on the robot uh
inter software interface that tells the robot where it's going to insert each thread that was done um with you know my
hand on the mouse for whatever that's worth so you were the one placing the targets yeah oh cool so like it you know
the the the robot uh with a computer vision provides a bunch of candidates and you kind of
finalize the decision right uh you know they the the software Engineers are amazing on this team and so they
actually provided an interface where you can essentially use a lasso tool and select a a prime area of brain real
estate and it will automatically avoid the blood vessels in that region and automatically place a bunch of targets
so you you know that allows you know the human robot operator to select uh really good areas of brain
and make dense applications of Targets in that in those regions the regions we think are going to have the most um High
Fidelity representations of finger movements and arm movement intentions I've seen like images of this
and for me with OCD it's for some reason a really doesn't uh I think there's a subreddit called oddly satisfying yeah
love that subreddit It's oddly satisfying to see the different Target sites avoiding the
blood vessels and uh also maximizing like the usefulness of those locations for the
signal it just feels good it's like ah as as a person who has a visceral reaction to the brain bleeding I can
tell you it's yes especially it's extremely satisfying watching the electrodes themselves go into the brain
and not cause bleeding yeah yeah so uh you said the feeling was of
relief when everything went perfectly yeah how deep in the brain can you currently go and uh eventually go let's
say on the neuralink side is it seems the deeper you go in the brain the more challenging it
becomes yeah so talking broadly about neurosurgery we can get anywhere uh it's routine for me to put
deeper brain stimulating electrodes uh near the very bottom of the brain uh entering from the top and
passing about a 2mm wire all the way into the bottom of the brain and that's not revolutionary a lot of people do
that uh and we can do that with very high Precision I I use a robot uh from Globus to do that surgery um you know
several times a month uh it's it's pretty routine what are your eyes in that situation what what are you seeing
what's what kind of Technology can you use to visualize where you are to light your way yeah so it's a cool process on
the software side you take a pre-operative MRI that's extremely high resolution data of the entire brain you
put the patient to sleep put their head in a frame that holds the skull very rigidly and then you take a CT scan of
their head while they're asleep with that frame on and then merge uh the MRI and the CT in
software you have a a plan based on the MRI where you can see these nuclei deep in the brain you can't see them on CT
but if you trust the merging of the two images then you indirectly know on the CT where that is and therefore
indirectly know where in reference to the titanium frame screwed to their head those targets are and so this is 60s
technology to manually compute trajectories given the entry point and Target uh and dial in some goofy looking
titanium um actuators uh with manual manual actuators with little tick marks on
them the modern version of that is to use a robot uh you know just like a a little CA arm you might see it building
cars at the Tesla Factory this small robot arm can show you the trajectory that you intended from the preop MRI and
establish a very rigid holder through which you can drill a small hole in the skull and pass a small rigid wire deep
into that area of the brain that's Hollow and put your electrode through that Hollow wire and then remove all of
that except the electrode uh so you end up with the electrode very very precisely placed far from the skull
surface now that's standard technology um that's already you know been out in the world for for a
while neuralink right now is focused entirely on cortical targets surface targets uh because there's no trivial
way to get say hundreds of wires deep inside the brain without doing a lot of damage so your question what do you see
well I see an MRI on a screen I can't see everything that that DBS electr is
passing through on its way to that deep Target and so it's accepted with this approach that there's going to be about
one in a hundred patients who have a a bleed somewhere in the brain uh as a result of passing that
wire blindly into the the Deep part of the brain that's not an acceptable safety
profile for neuralink we uh start from the position that we want this to be dramatically maybe two or three orders
of magnitude safer than that uh safe enough really that you know you or I without a profound medical problem might
on our lunch break someday say yeah sure I'll get that I've been meaning to upgrade to the latest
version and so that the safety constraints given that are high and so we haven't uh settled on a final
solution for arbitrarily approaching deep Targets in the brain it's interesting because like you have to
avoid blood vessels somehow you have to maybe there's creative ways of doing the same thing like mapping out high
resolution geometry of blood vessels and then you can go in blind but like how do you map out that
in a way that's like super stable it's there's a lot of interesting challenges there right yeah but there's a lot to do
on the surface Lu exactly so we've got Vision on the surface um you know we we actually have made a huge amount of
progress sewing uh electrodes into the spinal cord uh as a potential workaround for a
spinal cord injury that would allow a brain mounted implant to Translate motor intentions to a spine mounted implant
that can affect muscle contractions in previously paralyzed arms and legs that's just incredible so like the
effort there is to try to bridge the brain to the spinal cord to the periphery peripheral nervous so uh how
hard is that to do we have that working in uh in very crude forms in animals that's amazing yeah we've done it so
similar to like with Nolan where he's able to digitally move the cursor here you're
doing uh the same kind of communication but with the actual defectors that you have yeah that's fascinating yeah so we
have anesthetized animals doing grasp and moving moving their legs and an sort of walking pattern uh again early days
uh but uh the future is bright for this kind of thing and and people with paralysis uh should look forward to that
bright future they're going to have options yeah and there's a lot of sort of uh intermediate or extra options
where you take like an Optimus robot like the uh the arm and to be able to control the arm yeah the the the fingers
the hands of the arm sure as a prosthetic are getting better too exoskeletons yeah so that that goes hand
in hand although I didn't quite understand until thinking about a deep doing more research about
neuralink how much you can do on the digital side so this digital telepathy yeah I I didn't quite understand that
you can really map the intention as you described in the hand knob area that you can map the intention
just imagine it think about it that intention can be mapped to actual action in the digital world right and now more
and more so much can be done in in the digital world that it it it can reconnect you to to the outside world it
can allow you to have freedom have Independence if you're a quadriplegic yeah that's really powerful like you can
go really far with that yeah our first part participant is he's incredible he's breaking World Records left and right
and he's having fun with it it's great um just going back to the surgery your whole
journey you uh mentioned to me offline you have surgery on Monday so you're like you're doing surgery all the time
yeah maybe the ridiculous question what does it take to get good at surgery practice repetitions you just same with
anything else you know there's a million ways of people saying the same thing and selling books saying it but do you call
it 10,000 hours do you call it you know spend some chunk of your life some percentage of your life focusing on this
obsessing about getting better at it um repetitions uh humility recognizing that you aren't perfect at any stage along
the way uh recognizing you've got improvements to make in your Technique being open to feedback and coaching from
people with a different perspective how to do it um and then um just the constant will to do
better uh that fortunately you know if you're not a sociopath I think your patients bring that with them to the
office visits every day they you know force you to want to do better all the time yeah just step up I mean it's a
real human being a real human being that you can help yeah so every surgery even if it's the same exact surgery is there
a lot of variability between that surging and a different person yeah a fair bit I mean a good example for us is
that the angle of the skull relative to the normal plane of the body axis of the skull over hand knob uh is
pretty wide variation I mean some people have really flat skulls and some people have really steeply angled skulls over
that area and that has you know consequences for or how their head can be fixed in in uh in sort of the frame
that we use um and how the robot has to approach the skull and um yeah people's people's bodies are built as differently
as you know the people you see walking down the street as as much variability in body shape and size as you see there
we see in brain anatomy and skull Anatomy um there are some people who we've had to kind of exclude from our
trial for having skulls that are too thick or too thin or scalp that's too thick or too thin um I think you know we
have like the middle 97% or so uh of people but you can't account for all human anatomy variability how
much like mushiness and mess is there CU I uh you know taking biology classes the diagrams are always really clean and
crisp Neuroscience the pictures of neurons are always was really nice and very um but whenever I look at pictures
of like real brains they're all I I don't know what is going on yeah uh so how much our biological systems in
reality like how hard is it to figure out what's going on not too bad uh once you really get used to this you know
that's where experience and and skill and uh education really come into play is if you stare at a thousand brains
it becomes easier to kind of mentally peel back the say for instance blood vessels that are obscuring the susai and
gyri you know kind of the wrinkle pattern of the surface of the brain occasionally when you're when you're
first starting to do this and you open the skull it doesn't match what you thought
you were going to see based on the MRI uh and with more experience you you learn to kind of peel back that layer of
blood vessels and see the underlying pattern of wrinkles in the brain and use that as a landmark for where you are the
wrinkles are a landmark so like yeah so I was describing hand knob earlier that's a pattern of the wrinkles in the
brain it's sort of this sort of Greek letter Omega shaped area of the brain so you could recognize the hand knob area
like if if I show you a thousand brains and give you like one minute with each you'd be like yep that's that sure and
so there is some uniqueness to that area of the brain like in terms of the geometry the topology of the thing
yeah where is it about in the it's so you have this strip of brain running down the top called the primary motor
area and I'm sure you've seen this picture of the homunculus laid over the surface of the brain the weird little
guy with huge lips and giant hands uh that guy sort of lay with his legs uh up at the top of the brain and
and face arm uh areas farther down and and then some kind of mouth lip tongue areas uh farther down and so the hand is
right in there and then the areas that control speech at least on the on the left side of the brain in most people
are are just below that and so uh any muscle that you voluntarily move in your body um the vast majority of that
references that strip or those intentions come from that strip of brain and the the wrinkle uh for hand knob is
right in the middle of that and vision is back here yep also on close to the surface vision's a little deeper uh and
so you know this gets to your question about how deep can you get um to do Vision we can't just do the surface of
the brain we have to be able to go in uh not not as as deep as we'd have to go for DBS but maybe a centimeter deeper
than we're used to for hand insertions uh and so that's you know work in progress that's a a new set of
challenges to overcome by the way you mentioned uh the Utah aray and I just saw a picture of that and that thing
looks terrifying yeah it's because of it's rigid and then if you look at the threads they're
flexible what can you say that's interesting to you about the flex that kind of approach of the the
flexible threads to to deliver the electrodes next to the neurons yeah I mean the the goal there comes from
experience I mean we stand on the shoulders of people that made Utah rays and and used Utah Rays for decades
before we ever even came along um neuralink arose partly this approach to technology arose out of a
need recognized after Utah Rays would fail routinely
because the rigid electrodes those spikes that are literally hammered using an air hammer into the
brain uh those spikes generate a bad immune response that encapsulates the the electrode spikes in
uh Scar Tissue essentially and so one of the projects that was being worked on in in the Anderson Lab at Caltech when I
got there was to to see if you could use chemo therapy to prevent the formation of scar like you know things are pretty
bad when you're jamming a bed of nails into the brain and then treating that with
chemotherapy to try to prevent Scar Tissue it's like you know maybe we've gotten off track here guys maybe there's
a fundamental redesign necessary and so nurl Link's approach of using highly flexible tiny
electrodes avoids a lot of the bleeding avoids a lot of the immune response that ends up happening uh when rigid
electrodes are pounded into the brain and so what we see is our electrode longevity and
functionality uh and the and the health of the brain tissue immediately surrounding the electrode uh is
excellent I mean it goes on for for years now in our animal models what do most people not understand about the
biology of the brain we mention the vasculature that's really interesting I think the most interesting maybe
underappreciated fact uh is that it really does control almost everything I
mean I don't know for out of the blue example imagine you you want a lever on fertility you want to be able to turn
fertility on and off I mean it there are legitimate Targets in the brain itself to modulate
fertility say um blood pressure you want to modulate blood pressure they're legitimate tar Targets in the brain for
doing that um things that aren't immediately obvious as brain
problems are potentially solvable in the brain um and so I think it's an under explored area for primary treatments of
of all the things that bother people that's a really fascinating way to look at it like there's a lot of conditions
we might think have nothing to do with the brain but they might just be symptoms of something that actually
started in the brain the actual source of the problem the primary source is the is something in the brain yeah not not
always I mean you know there kidney disease is real uh but um there are levers you can pull in the brain that
affect all of the all of these systems there's knobs yeah onoff switches and knobs in the
brain from which this all or originates yeah uh would you have a neuralink chip implanted in your brain yeah
um I think use case right now is use a mouse right I can already do
that and so there's no value proposition uh on safety grounds alone sure I would do it tomorrow you know you say the use
case of the mouse is after like researching all this and part of is just watching Nolan have
so much fun if you can get that bits per second like really high with a the mouse like
being able to interact because if you think about the the way the on the smartphone the way you swipe that was
transformational yeah how we interact with a thing it's subtle you don't realize it but you're able to touch a
phone and to uh scroll with your finger that's like that changed everything that people were sure you need a keyboard to
type and that uh there's a lot of HCI aspects to that that changed how we interact
with Compu computers so there could be a certain rate of speed with the mouse that would change everything yes like
you might be able to just click around a screen extremely fast and that if it I I seem must have gotten the
neur link for much more rapid interaction with the digital devices yeah I think recording speech intentions
from the brain might might change things as well you know the value proposition for the average person
um a keyboard is a pretty clunky human interface requires a lot of training it's you know highly variable in the
maximum performance that the average person can uh can achieve uh I think taking that out of
the equation and just having a natural you know word to computer interface uh might change things for a
lot of people it'd be hilarious if if that is the reason people do it even if you have speech to text that's extremely
accurate it currently isn't right but it say gotten super accurate it'd be hilarious if people went for neuralink
just so you avoid the embarrassing aspect of speaking like looking like a douchebag speaking to your phone in
public which is a real like that's a real constraint yeah I mean with a bone conducting case uh that can be an
invisible headphone say um and the ability to think words into software and have it respond to
you um you know that starts to sound sort of like embedded super intelligence you know if you can silently ask for the
Wikipedia article on any subject and have it read to you without any observable change happening in the
outside world uh you know for one thing standardized testing is obsolete
yeah if it's done well on the ux side it could change I don't know if it transforms Society but it really uh can
create a kind of shift in the way we interact with digital devices and the way that a smartphone did yeah I would
um just having to look into the safety of everything involved I would totally try it so it doesn't have to go to some
like incredible thing where you have it connects to your vision or to some other like you connects all over your brain
that could be like just connecting to the hand knob uh you might have a lot of
interesting interaction human computer interaction possibilities yeah that's really interesting yeah and the
technology on the academic side is progressing at light speed here I think there was a really amazing paper out of
UC Davis Sergey stavis lab that basically made a initial solve of speech decode it was something like 125 5,000
words uh that they were getting with you know very high accuracy which is so you're just thinking the word yeah
thinking the word and you're able to get it yeah oh boy like you have to have the intention
of speaking it right so like do that inner voice man it's so amazing to me that you can do the intention to Signal
mapping all you have to do is just imagine yourself doing it and if if you get the feedback that it
actually worked you can get really good at that like your brain will first of all adjust and you develop like any
other skill yeah like touch typing you develop in that same kind of way that is that is really to me it's just really
fascinating yeah to be able to even to play with that honestly like I would get a new link just to be able to play with
that just to play with the capacity the capability of my mind to learn this skill it's like learning the skill of
typing or learning the skill of moving a mouse it's another skill of moving the mouse not with my physical body but with
my mind I can't wait to see what people do with it I feel like we're we're cavemen right now we're we're like
banging rocks with a stick and thinking that we're making music um at some point when these are more widespread there's
going to be the equivalent of a of a piano that you know someone someone can make art with their brain in a way that
we didn't even anticipate um I'm looking forward to it give it to like a teenager like anytime
I think I'm good at something I'll always go to like I don't know even even uh even with the the bit per second of
playing a video game you realize you give it to a teen you give a your link to a teenager just a large number of
them the kind of stuff you they get good at stuff they're going to get like hundreds of uh bits per second yeah even
just with the current technology probably probably just uh cuz it's also addicting how like the the the number go
up aspect of it of like improving and training cuz it is it's almost like a skill and plus there's a software on the
other end that adapts to you and especially if the adapting procedure algorithm becomes better and better and
better you like learning together yeah we're scratching the surface on that right now there's so much more to do so
on the complete other side of it you have an RFID chip yeah implanted in you yeah this so I here nice so this is
subtle thing it's a passive device that you use for unlocking like a a safe with top
secrets or what what is what do you use it for what's the story behind it I'm not the first one there's there's this
whole community of weirdo biohackers that uh have done this stuff and I think one of the early use cases was storing
you know private crypto wallet keys and and whatever um I dabbled in that a bit and and had some fun with it um you have
some bigcoin implanted in your body somewhere you can't tell where yeah yeah actually yeah uh it was you know the
modern day equivalent of finding change in the sofa cushions after I I put some orphan crypto on there that I thought
was worthless and forgot about it for a few years went back and found that some community of people loved it uh and had
propped up the value of it and so it had gone up 50 fold so there was a lot of change in those
cushions that's hilarious but the the primary use case is mostly as a as a tech demonstrator you know it it has my
business card on it you can scan that in uh by touching it to your phone it opens the front door to my house you know
whatever simple stuff it's a cool step it's a cool leap to implant something in your body I mean it has perhaps that's
it's a similar leap to a neur link because for a lot of people that kind of notion of putting putting something
inside your body something electronic inside a biological system is a big leap yeah we have a kind of a mysticism
around the barrier of our skin we're completely fine with knee Replacements hip replacements you know uh dental
implants um but uh you know there's a mysticism still around the inviable barrier that the skull represents and I
think that needs to be treated like any other uh pragmatic barrier you know it's the question
isn't how how incredible is it to open the skull the question is you know what benefit can we provide so from all the
surgeries you've done from everything you understand the brain how much doe
